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Frontiers in Health Services

Post-quantum cryptography for healthcare: securing medical data, connected devices, and digital health infrastructure

Sheng-Ping Wu, Sheng-Ding Wu, Kuo-Cheng Lu, Chia‐Chao Wu

Published Jul 16, 2026• 1 citation
Publisher

Abstract

Healthcare systems increasingly depend on interoperable electronic health records, picture archiving and communication systems, cloud analytics, remote monitoring, and connected medical devices. These workflows create a long-lived confidentiality problem: clinical, genomic, pediatric, psychiatric, and family-linked data may remain sensitive for decades, whereas the public-key algorithms that protect current transport and identity systems are vulnerable to future cryptographically relevant quantum computers. Shor's algorithm threatens RSA, finite-field Diffie-Hellman, elliptic-curve Diffie-Hellman, and elliptic-curve signatures, while Grover's algorithm reduces the effective security margin of symmetric primitives. This review validates the post-quantum transition pathway for healthcare and distinguishes software-deployable post-quantum cryptography from hardware-specialized quantum key distribution. We summarize the standardized NIST primitives, correct the status of Falcon/FN-DSA as a FIPS 206 algorithm still in development, analyze deployment constraints in Internet of Medical Things environments, and map cryptographic migration to healthcare governance. A staged, hybrid, crypto-agile migration strategy is recommended: prioritize long-confidentiality data, inventory cryptographic dependencies, deploy hybrid key establishment at enterprise gateways, reserve QKD for selected high-value fixed links, and require vendor update pathways for clinical devices.

DOI
10.3389/frhs.2026.1901282

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Healthcare systems increasingly depend on interoperable electronic health records, picture archiving and communication systems, cloud analytics, remote monitoring, and connected medical devices. These workflows create a long-lived confidentiality problem: clinical, genomic, pediatric, psychiatric, and family-linked data may remain sensitive for decades, whereas the public-key algorithms that protect current transport and identity systems are vulnerable to future cryptographically relevant quantum computers. Shor's algorithm threatens RSA, finite-field Diffie-Hellman, elliptic-curve Diffie-Hellman, and elliptic-curve signatures, while Grover's algorithm reduces the effective security margin of symmetric primitives. This review validates the post-quantum transition pathway for healthcare and distinguishes software-deployable post-quantum cryptography from hardware-specialized quantum key distribution. We summarize the standardized NIST primitives, correct the status of Falcon/FN-DSA as a FIPS 206 algorithm still in development, analyze deployment constraints in Internet of Medical Things environments, and map cryptographic migration to healthcare governance. A staged, hybrid, crypto-agile migration strategy is recommended: prioritize long-confidentiality data, inventory cryptographic dependencies, deploy hybrid key establishment at enterprise gateways, reserve QKD for selected high-value fixed links, and require vendor update pathways for clinical devices.
With the progress of quantum computing, medical institutions that use classical public-key cryptography to secure the confidentiality of long-lasting and delicate healthcare information are facing great security challenges.This research aims to suggest a policy framework for Post-Quantum Cryptographic Policy (PQCP) to facilitate systematic shift of healthcare infrastructures to quantum resistant infrastructure security.It seamlessly combines cryptographic asset discovery, quantum-risk assessment, asset prioritization, cryptoagility, hybrid cryptographic migration, secure key management, governance, compliance monitoring, and ongoing security evaluation.It covers electronic health records, healthcare platforms in the cloud, medical imaging, telemedicine applications and resource-limited Internet of Medical Things devices.A risk-oriented migration strategy gives institutions the ability to prioritize systems based on the amount of data in a system, the vulnerabilities of the cryptographic functions used, the clinical criticality of the system, and the length of time the information must be kept confidential.There are hybrid (classical and post-quantum) mechanisms for gradual migration and interoperability or clinical continuity.Finally, the suggested framework offers a structured approach to enhance the preparedness of healthcare institutions, adherence to regulations, resilience against cryptographic attacks, and long-term protection of healthcare information from the evolving quantum cybersecurity landscape.
The increasing digitalization of the healthcare system, driven by electronic health records, medical IoT devices, and AI-aided diagnostics, has significantly expanded the attack surface for cyber threats. Although current cryptographic protocols provide sufficient security against classical adversaries, new developments in quantum computing threaten the confidentiality, integrity, and availability of medical information as never before. Shor’s algorithm could break widely used asymmetric encryption systems, and Grover’s algorithm weakens symmetric ones, which could render modern healthcare security systems obsolete. This review provides an in-depth and organized analysis of the evolving quantum threat environment in healthcare ecosystems and of the need to move toward quantum-resilient security architectures. It synthesizes the existing literature on post-quantum cryptography (PQC) and identifies lattice-based, hash-based, multivariate, and code-based algorithms as potentially viable long-term replacements. Moreover, it examines the cybersecurity issues that quantum-enabled attacks pose to medical IoT systems, clinical decision-support systems, wearable sensors, telemedicine systems, and cloud-based health information exchanges. The review also covers hybrid quantum-classical defenses, quantum key distribution (QKD), quantum random number generation (QRNG), and blockchain-based trust systems that aim to make systems resilient to advanced persistent quantum attacks. This paper identifies key gaps and outlines future research directions for developing quantum-secure medical systems. The results highlight the importance of early adoption of PQC standards and a layered cyber defense approach to protect patient privacy, ensure regulatory compliance, and retain trust in next-generation digital medical data communication.
Quantum computing is no longer a distant concern for cybersecurity planning. Its progress has raised serious questions about the long-term reliability of widely used public-key cryptographic systems, especially RSA, elliptic curve cryptography, and related key exchange mechanisms that currently protect digital communication, cloud services, financial transactions, government systems, and enterprise information assets. The main concern is that powerful quantum algorithms could weaken the mathematical assumptions on which these systems depend, creating future risks for encrypted data, digital signatures, identity systems, and secure network protocols (Shor, 1994; Mosca, 2018). Post-quantum cryptography has therefore become a major cybersecurity readiness priority, not only as a technical replacement for vulnerable algorithms, but as a broader organizational migration challenge. Effective preparation requires cryptographic asset inventory, risk classification, crypto-agility, vendor coordination, interoperability testing, and phased deployment across complex information systems (Kumar, 2022; Campbell, 2025). This article examines the cybersecurity implications of quantum computing and reviews the major post-quantum cryptographic algorithm families, current standardization efforts, enterprise migration barriers, and strategic readiness measures needed for the quantum computing era. It also discusses the importance of aligning post-quantum migration with existing cybersecurity governance, information systems management, and long-term digital resilience planning. By emphasizing early preparation, structured migration, and continuous cryptographic governance, the article argues that organizations can reduce future quantum-related exposure and strengthen the security of critical digital infrastructure before large-scale quantum attacks become practical (NIST, 2024; NCCoE, 2025).
Quantum computers are capable of solving problems that classical computers cannot, particularly in the realm of cryptographic algorithms such as RSA, DSA, and ECC. Post quantum cryptography refers classical cryptographic algorithm that are designed to secure sensitive data. This research explores the application of post-quantum cryptographic techniques in healthcare systems, with a specific focus on integrating Quantum Key Distribution (QKD) with Genetic Algorithms (GA) for enhanced key optimization. As quantum computing advances, traditional cryptographic systems employed in health care are more and more vulnerable to being broken. Security of sensitive patient information—like electronic health records (EHRs), diagnostic data, and personally identifiable information— requires strong solutions that can handle future quantum attacks. Post-quantum cryptography (PQC) provides a hopeful way forward by employing quantum computer-resistant algorithms. This paper investigates the deployment of PQC methods—e.g., lattice-based, hash-based, and multivariate polynomial cryptography—inside healthcare systems to improve data confidentiality, integrity, and availability. It assesses the weaknesses of present encryption technologies and introduces PQC as a necessary update to protect patient information from sophisticated cyberattacks. The study also addresses the interoperability, computational overhead, and infrastructure readiness challenges of implementing PQC in healthcare. By implementing quantum-resilient cryptographic protocols, healthcare facilities are able to future-proof data protection practices and guarantee the safeguarding of patient data in an era governed by quantum computing.
The rapid advancement of quantum computing poses a significant threat to current cryptographic standards, particularly those securing electronic health records (EHRs) in healthcare systems.Traditional encryption methods such as RSA, ECC, and AES, while robust against classical attacks, are vulnerable to quantum algorithms like Shor's and Grover's, which can efficiently break cryptographic keys and compromise patient data integrity.As healthcare systems become increasingly interconnected through the Internet of Things (IoT) and cloud-based infrastructures, the need for quantum-resistant security mechanisms becomes paramount.Post-Quantum Cryptography (PQC) emerges as a viable solution to future-proof EHR security by employing lattice-based, hash-based, code-based, and multivariate polynomial cryptographic techniques that remain resistant to quantum attacks.This paper explores the implications of quantum computing on healthcare cybersecurity, emphasizing the vulnerabilities of existing encryption protocols and the necessity of transitioning toward PQC frameworks.Furthermore, we examine the integration of PQC within healthcare infrastructures, focusing on key exchange mechanisms, digital signatures, and end-to-end encryption for secure EHR transactions.Additionally, the study highlights regulatory and compliance considerations, including the National Institute of Standards and Technology (NIST) PQC standardization efforts and the role of Zero Trust security models in mitigating quantum-era cyber risks.Case studies illustrate successful implementations of PQC in healthcare networks, demonstrating its feasibility and effectiveness in safeguarding sensitive medical information.By adopting quantum-resistant cryptographic standards, healthcare institutions can proactively defend against emerging cyber threats, ensuring data confidentiality, integrity, and long-term resilience in the face of quantum computing advancements.
The prospect of cryptographically relevant quantum computers threatens public-key primitives underpinning modern digital infrastructure, including RSA, Diffie-Hellman, and elliptic-curve cryptography. Post-quantum cryptography (PQC) responds with algorithms believed to be hard for both classical and quantum adversaries. In August 2024, the U.S. National Institute of Standards and Technology (NIST) finalised the first three PQC standards: FIPS 203 (ML-KEM, based on Kyber), FIPS 204 (ML-DSA, based on Dilithium), and FIPS 205 (SLH-DSA, based on SPHINCS+). This paper surveys the algorithmic families behind these standards, the harvest-now-decrypt-later threat model, hybrid migration strategies, performance trade-offs, and the engineering challenges of transitioning the global cryptographic stack. We examine deployment progress in TLS, SSH, X.509, and constrained devices, and outline open research questions on side-channel security, falcon-style signatures, and the long-term replacement schedule for classical asymmetric cryptography.