This paper surveys the emerging field of hybrid quantum–classical (HQC) architectures for medical image analysis, with a particular focus on COVID-19 classification as a rep-resentative application. Despite extensive progress in quantum machine learning, there is still a lack of structured taxonomy-driven analysis that systematically characterizes how quantum components are integrated within hybrid imaging pipelines. This study pro-vides a structured review of representative HQC models, categorizing existing approaches based on the functional role of quantum modules, including front-end processing, feature extraction, and classification layers. A comparative analysis is conducted to examine how these architectural design choices relate to reported performance across different ex-perimental settings. The review shows that hybrid models can achieve strong binary classification performance under simulation conditions, particularly when quantum cir-cuits are used as feature extractors. However, performance in multi-class scenarios remains inconsistent and highly sensitive to encoding strategies, circuit design, and optimization settings. In addition, most existing studies rely on simulator-based evaluations, limited or single-source datasets, and non-standardized benchmarking protocols, which restrict reproducibility and generalization. Real-hardware validation remains scarce, and no consistent evidence of task-level quantum advantage over optimized classical baselines has been demonstrated. Overall, current HQC-based approaches should be considered exploratory rather than clinically validated solutions. Future progress requires stand-ardized benchmarking, multi-institutional validation, hardware-aware evaluation, and the development of interpretable hybrid architectures that respect NISQ-era constraints.
This paper surveys the emerging field of hybrid quantum–classical (HQC) architectures for medical image analysis, with a particular focus on COVID-19 classification as a rep-resentative application. Despite extensive progress in quantum machine learning, there is still a lack of structured taxonomy-driven analysis that systematically characterizes how quantum components are integrated within hybrid imaging pipelines. This study pro-vides a structured review of representative HQC models, categorizing existing approaches based on the functional role of quantum modules, including front-end processing, feature extraction, and classification layers. A comparative analysis is conducted to examine how these architectural design choices relate to reported performance across different ex-perimental settings. The review shows that hybrid models can achieve strong binary classification performance under simulation conditions, particularly when quantum cir-cuits are used as feature extractors. However, performance in multi-class scenarios remains inconsistent and highly sensitive to encoding strategies, circuit design, and optimization settings. In addition, most existing studies rely on simulator-based evaluations, limited or single-source datasets, and non-standardized benchmarking protocols, which restrict reproducibility and generalization. Real-hardware validation remains scarce, and no consistent evidence of task-level quantum advantage over optimized classical baselines has been demonstrated. Overall, current HQC-based approaches should be considered exploratory rather than clinically validated solutions. Future progress requires stand-ardized benchmarking, multi-institutional validation, hardware-aware evaluation, and the development of interpretable hybrid architectures that respect NISQ-era constraints.
Deep learning techniques have significantly enhanced medical image classification for disease diagnosis. However, traditional deep learning models face several challenges, such as dependence on large annotated datasets, complex architectural layers, and millions of trainable parameters, which can increase computational load and cause overfitting. Although quantum computing offers potential for parallel processing and improved feature representation, its practical use is limited by the current capabilities of Noisy Intermediate-Scale Quantum (NISQ) hardware. To overcome these issues, Hybrid Quantum–Classical Convolutional Neural Networks (HQCNNs) have been developed, using quantum properties like superposition and entanglement to improve feature extraction and classification of medical images. This review offers a thorough analysis of 50 peer-reviewed studies published from 2021 to 2026 and introduces a taxonomy of HQCNN architectures. It classifies existing approaches into three categories: Quantum-to-Classical, Classical-to-Quantum, and Hybrid Quantum Transfer Learning. The studies reviewed encompass a diverse range of medical imaging applications, including binary and multi-class disease classification using X-ray, CT, MRI, ultrasound, dermoscopic, retinal, and mammographic images. Additionally, the review compares HQCNNs with their classical CNN counterparts, exploring how factors like quantum circuit design, dataset size, class imbalance, task complexity, evaluation protocols, and hardware limitations influence classification performance. It concludes with an analysis of the key limitations of current HQCNN models, discusses challenges in deploying NISQ devices practically, and proposes future research directions to bridge the gap between experimental HQCNN frameworks and reliable clinical diagnostic systems.
Purpose This study investigates the integration of quantum-enhanced machine learning (QML) into medical image analysis, focusing on classification and feature extraction tasks. It aims to evaluate whether hybrid quantum-classical models can overcome the limitations of traditional machine learning in handling high-dimensional, clinically relevant imaging data. Design/methodology/approach Hybrid architectures combining classical preprocessing with quantum components, specifically variational quantum circuits (VQCs) and quantum kernel methods, were developed and implemented in simulated quantum environments using Qiskit and PennyLane on Google Colab. Publicly available datasets (ChestX-ray14, Brain Tumor MRI and CT Hemorrhage) were preprocessed and encoded into quantum states. Model performance was evaluated against classical baselines (MLP and CNN) using accuracy, precision, recall, F1-score, convergence speed and trainable parameters. Findings Quantum-enhanced models achieved competitive or superior performance compared to classical models with significantly fewer trainable parameters and faster convergence. The Quantum Kernel SVM demonstrated the highest precision (89.1%) and F1-score (88.5%) using only 8 parameters, while VQC models converged up to 2× faster than classical baselines. These results highlight the potential of QML to improve efficiency, robustness and scalability in diagnostic imaging workflows, particularly in resource-constrained or data-limited settings. Research limitations/implications The study relies on simulated quantum environments, which do not capture hardware noise or qubit limitations. Future work will extend to real quantum devices, multimodal data integration and interpretability strategies. Practical implications Quantum kernel methods and lightweight VQC architectures enable faster, resource-efficient diagnostic modeling, making them suitable for clinical environments with limited computational capacity or time-sensitive decision-making needs. Social implications Improving the efficiency and accessibility of medical image analysis has the potential to support faster diagnosis and enhance healthcare delivery, particularly in underserved or resource-limited regions. Originality/value This study provides a practical evaluation of hybrid quantum-classical models applied to multiple real medical imaging datasets in a reproducible simulated environment. It offers an early-stage framework demonstrating how QML techniques can be integrated into existing machine learning pipelines for medical image analysis.
Noisy Intermediate-Scale Quantum (NISQ) devices have led to the creation of hybrid quantum-classical algorithms, which have provided an innovative design to improve classical machine learning. This article focuses on a review of Hybrid Quantum-Classical Neural Networks (H-QCNNs) in image classification, which is an emerging area that attempts to exploit the representational ability of parameterized quantum circuits (PQCs) and the proven feature extraction capabilities of classical deep learning. We empirically examine the current tendencies in architecture, such as quanvolutional networks, sequential models, and variational quantum classifiers, and critically assess their performance on standard and custom data. The literature analysis shows a large performance difference between noiseless simulation and execution on real hardware, indicating the highly problematic aspects of scaling beyond binary tasks, quantum noise, and a lack of standardized benchmarking. Moreover, we mention such innovative contributions as the small H-QNN model that offers comparable accuracy, yet meets strict NISQ requirements. Last but not least, the current review offers a systematic taxonomy of H-QCNN architectures, a comparative study of methodology options, and a clear roadmap to future research to reach a workable quantum advantage in computer vision. It is a resource to the beginners as well as a reference to the professionals working in the field, so the field would be moved to more powerful, scalable, and hardware-conscious ways of implementation.
Quantum machine learning has emerged as a promising application domain for near-term quantum hardware, particularly through hybrid quantum-classical models that leverage both classical and quantum processing. Although numerous hybrid architectures have been proposed and demonstrated successfully on benchmark tasks, a significant open question remains regarding the specific contribution of quantum components to the overall performance of these models. In this work, we aim to shed light on the impact of quantum processing within hybrid quantum-classical neural network architectures through a rigorous statistical study under ideal, noise-free simulation. We systematically assess a selection of commonly used HQNN architectures on three binary medical classification tasks covering medical signal data as well as planar and volumetric images. In doing so, we examine the influence attributable to classical and quantum aspects such as encoding schemes, entanglement, and circuit size. Within this experimental setting, we find that in best-case scenarios, hybrid models show performance comparable to their classical counterparts. However, in most cases, performance metrics deteriorate when the investigated QNN components replace matched classical processing layers. Our multi-modal analysis provides empirical insights into the contributions of the tested quantum components and advocates for cautious claims and design choices for hybrid models in near-term applications.
Abstract The convergence of quantum computing and medical image analysis has emerged as a promising frontier for advancing diagnostic intelligence beyond the limits of classical machine learning. Recent developments in quantum hardware and quantum machine learning (QML) algorithms have stimulated growing interest in their potential to enhance complex medical imaging tasks, including disease classification, image segmentation, and clinical decision support (Wei et al., 2023; Ullah and Garcia-Zapirain, 2024). This study presents a comprehensive review and synthesis of state-of-the-art QML methodologies applied to medical imaging, systematically examining both theoretical foundations and empirical implementations. We analyze quantum-based and hybrid quantum–classical models employed across modalities such as MRI, CT, X-ray, and histopathological imaging, with particular attention to classification accuracy, computational efficiency, and diagnostic robustness (Maheshwari et al., 2022; ElBedoui et al., 2025). Our findings reveal clear trends indicating that hybrid quantum–classical approaches currently dominate practical applications, consistently outperforming purely classical baselines in select low-dimensional and domain-specific diagnostic tasks. Performance gains are most evident in feature-rich yet data-constrained scenarios, where quantum kernels and variational circuits demonstrate enhanced representational capacity (Ajlouni et al., 2023; Landman et al., 2022). However, these advantages remain context-dependent and sensitive to noise, circuit depth, and encoding strategies. Overall, QML holds significant promise for improving medical image-based diagnosis, but its widespread clinical adoption is constrained by hardware scalability, limited qubit coherence, and unresolved data encoding challenges. Addressing these limitations will be critical for translating QML from experimental feasibility to routine medical practice (Marengo and Santamato, 2025; Rawas and AlSaeed, 2026).
Medical image classification is a critical component of modern healthcare; however, accurate diagnosis remains challenging due to limited annotated datasets, class imbalance, and the high dimensionality of medical imaging data. To address these challenges, a hybrid quantum-classical neural network (HQCNN) is proposed, integrating classical deep learning with variational quantum learning for medical image classification. The proposed architecture combines a five-layer convolutional neural network (CNN) for hierarchical feature extraction with a lightweight 4-qubit variational quantum circuit (VQC) incorporating quantum state encoding, superposition and entanglement mechanisms, and a quantum attention-Fourier (QAF) module. This hybrid design aims to improve nonlinear feature representation and quantum parameter efficiency while maintaining a shallow quantum circuit suitable for noisy intermediate-scale quantum (NISQ)-era constraints. Experimental evaluation on six MedMNIST benchmark datasets demonstrated competitive performance across both binary and multi-class classification tasks. HQCNN achieved 98.88% accuracy on the binary subset of PathMNIST (classes 0 vs. 1), 97.61% accuracy on the multi-class OrganAMNIST dataset, and 86.29% accuracy on BreastMNIST. Comparative experiments and statistical analyses demonstrated consistent improvements over the controlled BHQNN baseline, while component-wise ablation studies showed that the QAF module, superposition and entanglement mechanisms, and expressive parameterized rotations contributed to classification performance in a complementary and dataset-dependent manner. Moreover, HQCNN reduced the number of trainable quantum parameters by approximately 55.6% compared with the baseline hybrid quantum neural network (BHQNN). Noise-aware simulations further showed that the model retained relatively stable predictive performance under moderate depolarizing noise, supporting further evaluation under near-term quantum computing conditions. Overall, the results demonstrate that HQCNN provides a parameter-efficient hybrid quantum-classical framework for medical image classification and offers a promising foundation for further investigation of quantum-enhanced medical image analysis.