While quantum machine learning (QML) is a burgeoning field for solving intricate computational problems, its utility for actual medical diagnosis—where hardware is currently limited—is still being debated. This study explores the viability of a hybrid classical–quantum system for identifying breast masses via a Variational Quantum Classifier (VQC). Using a real-world breast cancer dataset, we established a binary task to separate benign from malignant cases. We handled clinical variables through standard encoding and normalization, then applied Principal Component Analysis (PCA) to compress the data into a format manageable for a low-qubit system. The quantum model, built on a parameterized variational circuit, was executed via a quantum simulator and benchmarked against a standard Support Vector Machine (SVM). Our findings show that the classical SVM outperformed the quantum approach (82.08% vs. 52.50%). However, the VQC still surpassed the threshold of random chance, even when restricted to only four qubits and minimal circuit depth.
While quantum machine learning (QML) is a burgeoning field for solving intricate computational problems, its utility for actual medical diagnosis—where hardware is currently limited—is still being debated. This study explores the viability of a hybrid classical–quantum system for identifying breast masses via a Variational Quantum Classifier (VQC). Using a real-world breast cancer dataset, we established a binary task to separate benign from malignant cases. We handled clinical variables through standard encoding and normalization, then applied Principal Component Analysis (PCA) to compress the data into a format manageable for a low-qubit system. The quantum model, built on a parameterized variational circuit, was executed via a quantum simulator and benchmarked against a standard Support Vector Machine (SVM). Our findings show that the classical SVM outperformed the quantum approach (82.08% vs. 52.50%). However, the VQC still surpassed the threshold of random chance, even when restricted to only four qubits and minimal circuit depth.
Early and accurate diagnosis of breast cancer plays a critical role in improving patient survival rates and reducing treatment costs. Classical machine learning algorithms such as Logistic Regression and Support Vector Machines (SVM) have demonstrated strong performance in medical diagnosis tasks; however, their scalability and representational limits motivate the exploration of emerging paradigms. Quantum Machine Learning (QML), particularly Variational Quantum Classifiers (VQC), has recently gained attention due to its potential to model complex decision boundaries using quantum circuits. This paper presents a comparative analysis between a Variational Quantum Classifier and classical machine learning models for binary breast cancer classification. The study employs dimensionality-reduced clinical data and evaluates model performance using accuracy, confusion matrices, decision boundary visualization, Principal Component Analysis (PCA), and Receiver Operating Characteristic (ROC) curves. Experimental results indicate that the VQC achieves competitive performance with classical approaches, demonstrating its feasibility for small-scale medical datasets and highlighting the promise of quantum-enhanced learning in healthcare applications.
Breast cancer is rated as one of the top leading diagnosed and deadliest cancers affecting women worldwide and causing high mortality rate among cancers. With the data-driven applications, hybrid quantum-classical machine learning models have evolved as significant alternatives for handling complex feature spaces with the growing interest in quantum computing. This paper presents a systematic comparative study of classical and quantum machine learning approaches for breast cancer classification using the Wisconsin Breast Cancer Dataset. In this architecture we have preprocessed classical feature vectors using standard normalized techniques and parallelly quantum states are mapped through data embedding techniques which relies on parameterized rotational gates. In this work we have implemented all quantum models using the Pennylane library, resulting in hybrid quantum–classical optimization on near-term quantum simulators. The comparison results in multiple classical and quantum models. In classical we have Support Vector Machine (SVM), K-Nearest Neighbors (KNN) and Convolutional Neural Networks (CNN), which are compared with the quantum-based models such as the Variational Quantum Classifier (VQC), Quantum Support Vector Machine (QSVM) and Quantum Convolutional Neural Network (QCNN). In QSVM, we have performed dimensionality reduction using Principal Component Analysis (PCA) before to quantum embedding, and quantum-generated features are used to train a classical linear SVM. The evaluation metrics results in accuracy, precision, recall, F1-score, ROC curves and confusion matrices. The classical models achieves the accuracy in the range of 94%-96%, whereas competitive performance of quantum models demonstrate depending on the embedding strategy and circuit configuration. In the implemented quantum models, the variational quantum classifier achieved the highest classification accuracy of 96.06%, surpassing other evaluated models. These results demonstrate quantum embedding combined with variational quantum circuits can effectively capture discriminative patterns in medical datasets, indicating the implementation of quantum machine learning models for breast cancer diagnosis with the present quantum simulating platforms.
In recent years, quantum machine learning (QML) has emerged as a promising approach for medical decision-making, with representative methods such as Quantum Support Vector Machines (QSVMs), Quantum Neural Networks (QNNs), and Variational Quantum Circuits (VQCs). Among these, VQCs are distinguished by their expressive capability; however, their training on small biomedical datasets often results in instability and high variance. To address this issue, we propose a heterogeneous ensemble of six shallow VQCs evaluated on the Wisconsin Breast Cancer Diagnostic (WBCD) dataset, which contains 569 diagnostic samples characterized by 30 cytological features and binary class labels differentiating benign and malignant cases. The ensemble introduces diversity through distinct feature maps, circuit architectures, and optimization strategies, using rotation gates (RX, RY, RZ) combined with entangling layers (CNOT, CZ). Model reliability is estimated from out-of-bag errors, with normalized weights calculated as the inverse of the mean squared error, and final decisions obtained via weighted soft voting. The preprocessing pipeline involves median imputation and standardization, followed by principal component analysis (PCA) to compress the 30-dimensional space into three to four principal components for quantum encoding. In our experiments, individual VQCs trained on the full dataset exhibited unstable accuracies ranging from 80% to 96% across three–four qubits, whereas the proposed ensemble achieved consistent performance of 95.71% (3 qubits) and 96.43% (4 qubits), reducing variance and matching strong classical baselines such as SVM and Random Forest. All models were implemented in PennyLane, utilizing the Lightning.qubit simulator for shot-free optimization and the default.mixed device for noise-aware evaluation, demonstrating the potential of weighted quantum ensembles for reliable biomedical classification.
A potential path forward is Quantum Machine Learning (QML), which aims to leverage quantum computing in conjunction with classical machine learning to enhance computing efficiency and the expressiveness of models. In this paper, two different quantum classifiers - Variational Quantum Classifier (VQC) and Quantum Kernel Support Vector Machine (QSVM) - are compared with three classical classifiers as baseline classifiers - Logistic Regression, Support Vector Machine (SVM), and a Multi-Layer Perceptron (MLP) - on the Breast Cancer Wisconsin dataset. The quantum circuits were created in the PennyLane framework and simulated on a classical backend. However, in terms of accuracy, classical Logistic Regression performed better with an accuracy of 97.8%, classical SVM and QSVM with an accuracy of 95.6% each, although the Quantum VQC achieved a lower accuracy of 88.9% and had a recall of 100% for the benign class, though it correctly identified only 12 of the 17 malignant cases (a malignant-class recall of approximately 70.6%). The drawback of quantum models is the higher training time; however, since the quantum circuit needs to be classically simulated, the quantum SVM took 23.29 seconds compared to less than 0.01 seconds for the classical linear models. These results indicate that for small structured datasets, classifiers based on quantum computing have not yet surpassed well-tuned classical counterparts. In some respects (e.g., benign-class recall), they perform competitively, though not on malignant-class recall, where the VQC in particular performed worse than the classical baselines, which is worth further investigation on real quantum computers.
Breast cancer continues to be among the most common causes of cancer death globally, with early and precise diagnosis playing a pivotal role in enhancing patient survival. Traditional machine learning (ML) techniques have shown great promise in the field of medical imaging and diagnosis; however, the emergence of quantum machine learning (QML) offers new avenues for the improvement of pattern discovery and diagnostic accuracy in high-dimensional medical data. This work describes a thorough benchmark comparison of quantum and classical machine learning methods for breast cancer diagnosis over the Wisconsin Diagnostic Breast Cancer data and mammographic image data. We compare variational quantum classifiers (VQC), quantum kernel methods (QKM), quantum convolutional neural networks (QCNNs), and hybrid quantum-classical neural structures with traditional classical baselines like support vector machines (SVM) and convolutional neural networks (CNN). QKM techniques perform better in high-dimensional feature spaces and better generalize on external validation sets. This implementation framework describes in depth how to develop, train, and deploy QML models in the clinical workflow, including optimization approaches, code structures, and deployment issues. The work demonstrates that it is possible to streamline breast cancer screening and diagnosis using QML with more accurate and more efficient solutions, which would lead to a huge impact on patient outcomes.
Accurate and timely diagnosis of breast cancer greatly improves treatment effectiveness and patient survival. In this work, we have suggested a quantum-classical framework for breast cancer classification. The pipeline starts with Principal Component Analysis (PCA) to preserve 90-95% of the dataset variance. Then feature selection is done with Random Forest and Recursive Feature Elimination, retaining the top 10 strongest features. The features are normalized and fed to a Variational Quantum Circuit (VQC) Classifier built with the Pennylane library. The VQC employs a parameterized quantum circuit (PQC) with multiple rotation gates and entanglement layers and is run over a simulator. The experimental results demonstrate that the VQC attained a classification test accuracy of 96.49% and AUC-ROC of 0.9985 over the test set. The model has produced robust generalization performance, shown by its excellent performance over unknown data. Results indicate that the VQC competes with the benchmarked classical models and has potential benefits in terms of applicability and scalability to healthcare applications in terms of accuracy. This work emphasizes the synergy of classical preprocessing and quantum classification in designing efficient and interpretable healthcare applications.