A JBI scoping review of quantum artificial intelligence (QAI) methods applied to neuropsychiatric disorders in healthcare and clinical research settings. The review maps QAI algorithms, hardware implementations, and clinical data modalities across conditions including depression, schizophrenia, bipolar disorder, dementia, epilepsy, ASD, ADHD, PTSD, and anxiety disorders. A secondary aim is to characterize structural barriers to translational integration across technical, data, clinical/operational, regulatory/ethical, and neuropsychiatric domain dimensions. Reporting follows PRISMA-ScR (Tricco et al. 2018). Seven databases will be searched (PubMed/MEDLINE, Embase, IEEE Xplore, ACM Digital Library, Scopus, Web of Science, PsycINFO). Date range: January 2016 to present.
A JBI scoping review of quantum artificial intelligence (QAI) methods applied to neuropsychiatric disorders in healthcare and clinical research settings. The review maps QAI algorithms, hardware implementations, and clinical data modalities across conditions including depression, schizophrenia, bipolar disorder, dementia, epilepsy, ASD, ADHD, PTSD, and anxiety disorders. A secondary aim is to characterize structural barriers to translational integration across technical, data, clinical/operational, regulatory/ethical, and neuropsychiatric domain dimensions. Reporting follows PRISMA-ScR (Tricco et al. 2018). Seven databases will be searched (PubMed/MEDLINE, Embase, IEEE Xplore, ACM Digital Library, Scopus, Web of Science, PsycINFO). Date range: January 2016 to present.
BACKGROUND AND OBJECTIVE: Brain disorder diagnosis and prediction remain challenging because neuroimaging, electrophysiological, behavioral, and multimodal data are high-dimensional, noisy, heterogeneous, and limited by small clinical cohorts. This systematic review synthesised applications of quantum artificial intelligence (QAI) for brain disorder diagnosis, prediction, detection, and monitoring. METHODS: Following PRISMA guidelines, studies published from 2016 to 13 January 2026 were retrieved from Scopus, Web of Science, and IEEE Xplore. After screening, 36 studies met the eligibility criteria and were qualitatively analysed according to disorder category, data modality, QAI method, implementation setting, validation strategy, and performance. RESULTS: At the broader disease-group level, neurodegenerative disorders were the most frequently investigated, followed by mental health and psychiatric disorders. At the individual level, Parkinson's disease and schizophrenia were the leading applications, followed by depression, anxiety, Alzheimer's disease, and stress-related tasks. MRI-based modalities were the most frequently used data source, followed by multimodal data and EEG. Methodologically, primary QAI approaches were dominated by quantum neural and QDL architectures, followed by quantum-inspired optimization or feature-selection methods and quantum-kernel/conventional QML classifiers. Qiskit/IBM Quantum and PennyLane were the most frequently reported quantum software frameworks. However, most studies relied on simulators, classical quantum-inspired implementations, or unclear implementation settings, with limited real-hardware evaluation. CONCLUSIONS: QAI shows emerging potential for brain disorder analysis, particularly through hybrid quantum-classical learning, quantum neural architectures, quantum-kernel methods, and quantum-inspired optimization. Nevertheless, current evidence remains preliminary and requires larger datasets, subject-level and external validation, fair classical benchmarking, noise-resilient circuits, real quantum hardware evaluation, explainability, and clinical validation.
AbstractQuantum artificial intelligence (QAI) combines quantum computing and AI to analyze complex healthcare data beyond classical limits. These methods offer new capabilities for discovering nonlinear neurobehavioral patterns, which could support precision psychiatry and the integration of epilepsy and mental health care. This systematic review analyzed published studies applying QAI to healthcare. Most work focused on imaging and drug discovery. Hybrid models combining quantum and classical algorithms showed early promise in small, noisy, or complex datasets. However, no studies addressed epilepsy-related psychiatric comorbidities, despite urgent needs in this domain. This poster identifies translational gaps and proposes future directions including the use of QAI for neuropsychiatric data, model interpretability, and privacy-preserving learning. Presented at: AMIA Annual Symposium 2025Location: Atlanta, Georgia, USADates: November 15 to 19, 2025 Authors: Joanne Osuchukwu, MD; Judith W. Dexheimer, PhD; John P. Pestian, PhD, MBA Affiliations:Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical CenterDepartment of Biomedical Informatics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA Original abstract published in the AMIA proceedings:https://knowledge.amia.org/A2025/content?act=2025Annuala949
Quantum Computing (QC) and Artificial Intelligence (AI) have emerged as key technologies in the evolution of Industry 6.0, driving advancements in automation and advanced analytics, and process optimization. Their integration holds the potential to revolutionize sectors such as data science, healthcare, finance, and cybersecurity by enabling faster and more efficient computations through qubits, superposition, and quantum entanglement. However, the lack of structured knowledge regarding specific QC methodologies and applications in AI hinders its optimal implementation and development. Consequently, this study aims to identify the applications and variables associated with QC-AI integration. To this end, a systematic literature review was conducted following the PRISMA 2020 methodology, drawing on studies from Scopus and Web of Science databases. This enabled the analysis of trends, limitations, and opportunities in this technological convergence. This study aims to systematically examine the intersection of quantum computing and artificial intelligence by identifying the key technological features, integration requirements, and sectoral applications that define the current state of the field. The review contributes by mapping existing research, highlighting methodological approaches, and revealing gaps that may guide targeted advancements in hybrid quantum AI systems. The insights generated have the potential to accelerate innovation in high-impact domains such as healthcare, finance, energy, and cybersecurity. The findings indicate that the main advances in QC applied to AI focus on quantum optimization, Quantum Machine Learning (QML), and post-quantum cryptography. Notably, sectors such as energy, healthcare, and finance have shown significant progress in adopting these technologies. For example, in healthcare, QML has been applied to simulate molecular interactions to accelerate drug discovery, and in finance, it enhances predictive models for market behavior. The study concludes that although QC demonstrates substantial potential to enhance AI, its broader adoption remains constrained by reliance on NISQ hardware, the need for effective error correction, and the limited scalability of hybrid quantum classical algorithms. Addressing these challenges will be essential to establishing QML as a cornerstone of technological innovation and digital transformation. Additionally, this review introduces an integrative framework that categorizes key AI QC convergence dimensions and proposes a classification of application areas based on technical requirements and algorithmic capabilities. These contributions aim to guide future experimental validations and hybrid model development.
Mental health disorders represent a growing global healthcare challenge affecting hundreds of millions of people worldwide. Major depressive disorder (MDD), anxiety disorders, post-traumatic stress disorder (PTSD), and Alzheimer’s disease place huge pressure on medical systems. A central challenge is early detection, which remains difficult due to the complexity of symptoms related to these diseases. Delayed diagnosis is also due to limited access to specialists and the multimodal complexity of relevant biomarkers, clinical assessments, neuroimaging, physiological signals, and behavioral data. Recent developments in artificial intelligence (AI) have demonstrated promising results in improving diagnostic support. However, classical AI still struggles to model high-dimensional correlations and inherent uncertainties that are common to cognitive-emotional data. This chapter explores quantum machine learning (QML) as a transformative paradigm to overcome these limitations. We provide a comprehensive overview of foundational QML architectures and evaluate its suitability for processing diverse healthcare data such as neuroimaging, wearable sensor inputs, and electronic health records (EHRs). We propose a new conceptual framework for a quantum-enabled clinical decision support system that integrates multimodal feature extraction. Taking into consideration the sensitivity of psychiatric data, we critically examine security imperatives that include federated learning and post-quantum privacy protection. This chapter aims to provide researchers and practitioners with a comprehensive perspective on how quantum computing (QC) may contribute to future intelligent mental healthcare.
Background Artificial Intelligence (AI) incorporation within healthcare applications has significantly helped in the improvement of healthcare diagnostics, patient forecasting, and clinical decision-making. The steady growing of medical data in terms of quantity, quality, and dimension poses more significant problems for traditional AI methods in terms of size, time, and computational efficiency. However, classical machine learning models often struggle with high-dimensional, imbalanced, and heterogeneous medical datasets, which limits their scalability and generalizability. The Quantum Artificial Intelligence (QAI) model, which combines quantum computing and machine learning in a complementary way, has emerged as one of the main trends to defeat these problems. This complementary approach is gaining more popularity, with the most advanced work being developed in this area, as it offers a fundamental explanation of current complexities and the underlying principles and their applications. Methodology This paper begins with the basic concepts of quantum computing and where it overlaps with AI. It then moves to a comparative approach, discussing various quantum machine learning algorithms such as quantum support vector machines, quantum neural networks, and variational quantum circuits. A comparative evaluation of quantum support vector machine, variational quantum classifier, quantum neural network, quantum K-means, and quantum Boltzmann machine is conducted using the Pima Indians Diabetes dataset to assess model behaviour and performance under standard metrics. Further detail is provided on the theoretical and practical implications of QAI in medical imaging, genomics, electronic health records, and drug discovery. Additionally, this paper examines platforms, tools, and quantum hardware used for QAI research, and discusses unique challenges currently faced in quantum technology. Results Unlike prior surveys that primarily provide conceptual overviews, this paper uniquely combines a comprehensive review with practical benchmarking of multiple quantum machine learning models on a benchmark medical dataset. This provides comparative insights into algorithmic performance under real-world constraints, particularly in relation to high-dimensional medical data, genomic data, electronic health records with large number of clinical attributes, radiology images, etc. In this study, dimensionality arises from multivariate clinical features encoded into quantum feature maps and the limitations of current quantum systems. Conclusion This paper aims to serve as a starting point for researchers and practitioners interested in the potential of quantum-enhanced AI to transform health data analytics. By identifying current limitations, evaluating the performance of emerging quantum machine learning approaches, and outlining gaps in the literature, the paper highlights future research directions necessary to advance QAI in healthcare. Overall, the findings outline both the potential and practical constraints of quantum models, offering a foundation for future work toward scalable, clinically applicable QAI solutions.
Artificial Intelligence (AI) continues to drive innovation across industries, but faces mounting challenges in computational scalability, optimization, and interpretability as models grow increasingly complex. Quantum Artificial Intelligence (QAI) offers a promising path forward by leveraging quantum phenomena such as superposition and entanglement to augment learning processes beyond classical limits. This review synthesizes the recent progress in QAI, emphasizing a comparative perspective framed through its advantages and limitations. It examines how hybrid quantum-classical architectures and variational models seek to address constraints in the Noisy Intermediate-Scale Quantum (NISQ) era, and how applications in healthcare, finance, and cybersecurity illustrate both the potential and the barriers of the field. While several studies have broadly mapped the growth of QAI in algorithms and applications, this paper adopts a different perspective: emphasizing comparative analysis through advantages and limitations. The focus is on where QAI offers unique opportunities, where it encounters obstacles distinct from classical AI and quantum computing, and what research directions may transform these challenges into breakthroughs. By situating QAI within this comparative framework, the paper provides a realistic yet forward-looking assessment of its trajectory as a paradigm poised to reshape computational intelligence.