A Systematic Review of Quantum Machine Learning in Education 5.0: Applications and Future Research Directions
Jimmy Aurelio Rosales Huamani, José Antonio Ogosi Auqui, Pedro Angel Toribio Pando, Ernan Capcha Milla, Jorge Luis Quinto Esquivel, Jose Luis Castillo Sequera
Quantum computing is one of the most promising emerging technologies, and quantum machine learning (QML), as one of its key branches, is attracting growing interest for intelligent data processing in education. This study conducted a systematic review of QML in the context of Education 5.0 using the PRISMA 2020 methodology. A total of 48 peer-reviewed articles from Springer, Scopus, IEEE Xplore, PubMed, MDPI, arXiv, and APS were analyzed. The results indicate that QML has significant potential to enhance personalized learning, optimize educational data processing, support curriculum innovation, and foster the development of quantum-related competencies. Representative QML algorithms, including Quantum Support Vector Machines, variational quantum circuits, and quantum neural networks, are identified as key technological enablers for future educational applications. However, significant challenges remain, such as limited access to quantum infrastructure, lack of specialized curricula, hardware constraints, and the need for interdisciplinary training. Overall, this study highlights the growing relevance of QML for adaptive learning, learning analytics, and intelligent educational systems, while emphasizing the need for further empirical validation and scalable implementation in real educational environments.
Quantum computing is one of the most promising emerging technologies, and quantum machine learning (QML), as one of its key branches, is attracting growing interest for intelligent data processing in education. This study conducted a systematic review of QML in the context of Education 5.0 using the PRISMA 2020 methodology. A total of 48 peer-reviewed articles from Springer, Scopus, IEEE Xplore, PubMed, MDPI, arXiv, and APS were analyzed. The results indicate that QML has significant potential to enhance personalized learning, optimize educational data processing, support curriculum innovation, and foster the development of quantum-related competencies. Representative QML algorithms, including Quantum Support Vector Machines, variational quantum circuits, and quantum neural networks, are identified as key technological enablers for future educational applications. However, significant challenges remain, such as limited access to quantum infrastructure, lack of specialized curricula, hardware constraints, and the need for interdisciplinary training. Overall, this study highlights the growing relevance of QML for adaptive learning, learning analytics, and intelligent educational systems, while emphasizing the need for further empirical validation and scalable implementation in real educational environments.
Quantum Machine Learning (QML) has emerged as a promising interdisciplinary paradigm that integrates quantum computing and machine learning to address limitations of classical approaches in processing complex high-dimensional heterogeneous and imbalanced medical data. This study presents a systematic literature review of QML applications in healthcare based on 94 primary studies published between 2020 and April 2025. The review follows Kitchenham’s guidelines and the PRISMA framework to ensure rigor transparency and reproducibility. Seven research questions were formulated to examine publication trends sources datasets topics quantum model categories algorithms methods and evaluation metrics. Findings reveal a sharp increase in publication activity after 2023 indicating growing academic interest in healthcare-oriented QML. Medical imaging datasets were most frequently used followed by signal-based and tabular datasets with 86.5% of studies relying on public data. Hybrid classical-quantum approaches including CNN-QSVM Quantum Neural Networks and Variational Quantum Classifiers were dominant because they combine classical feature extraction with quantum-enhanced learning. However most studies were conducted in simulation environments rather than real hardware reflecting NISQ limitations including noise decoherence limited qubits and circuit depth constraints. Many results used small curated or imbalanced datasets raising concerns regarding generalizability reproducibility and clinical validity. Although numerous studies reported high accuracy standardized evaluation protocols external validation and uncertainty assessment remain limited. Overall QML in healthcare remains exploratory with substantial potential but significant barriers. This review highlights progress gaps and future directions emphasizing clinically representative datasets robust benchmarking interpretable noise-resilient models and real-hardware implementation to support trustworthy deployment in healthcare systems worldwide settings today.
Quantum machine learning (QML) has emerged as a promising interdisciplinary field that integrates principles of quantum computing with machine learning techniques to address complex computational challenges. By leveraging quantum phenomena such as superposition and entanglement, QML aims to enhance learning efficiency, improve model performance, and enable the exploration of high-dimensional feature spaces that are intractable for classical methods. This paper presents a comprehensive review of recent developments in QML, covering fundamental concepts, algorithmic taxonomies, data encoding techniques, implementation challenges, and real-world applications. Key approaches, including quantum support vector machines (QSVM), variational quantum circuits (VQC), and quantum neural networks (QNN), are systematically analyzed. Furthermore, critical challenges, including noisy intermediate-scale quantum (NISQ) limitations, barren plateaus, data encoding bottlenecks, and the lack of demonstrated quantum advantage, are discussed in detail. The review also highlights emerging applications in material informatics, energy systems, healthcare, and optimization problems. Finally, future research directions are outlined, emphasizing the need for advancements in quantum hardware, scalable algorithms, hybrid frameworks, and standardized benchmarking. This work aims to provide a structured perspective on the current state of QML and to identify opportunities in deploy it effectively in solve real-world problems.
The rapid advancement of artificial intelligence has positioned Machine Learning (ML) as a cornerstone technology across scientific and industrial domains. In parallel, the emergence of quantum computing has catalyzed a new interdisciplinary field—Quantum Machine Learning (QML)—which promises to transcend the computational barriers faced by classical algorithms. This review paper systematically examines the evolution of ML from foundational statistical models to contemporary transformer architectures, and provides a structured analysis of QML paradigms including variational quantum circuits (VQCs), quantum kernel methods, and quantum neural networks (QNNs). Drawing from 95+ peer-reviewed publications indexed in Scopus and Science Citation Index (SCI) journals—with particular emphasis on 2025–2026 publications in IEEE Access, Nature Communications, Nature Computational Science, and Physical Review Letters—we analyze performance benchmarks, identify hardware constraints, and outline algorithmic innovations shaping the near-term quantum advantage landscape. Our findings indicate that while classical ML retains superiority in large-scale perception tasks, QML demonstrates significant advantages in combinatorial optimization and quantum chemistry simulation. Recent 2025 advances in error mitigation on superconducting qubits and improved VQC barren-plateau mitigation are narrowing this gap rapidly. The paper concludes with a forward-looking research agenda covering fault-tolerant QML, hybrid architectures, and quantum NLP.
Abstract Quantum Machine Learning (QML) is an emerging interdisciplinary field that merges quantum computing with classical machine learning (ML) to enhance computational efficiency, scalability, and accuracy in data-driven tasks. By leveraging quantum properties such as superposition, entanglement, and quantum parallelism, QML has the potential to solve complex problems that are intractable for classical models. This survey provides a comprehensive, systematic review of recent advancements in QML, conducted following the PRISMA 2020 guidelines and covering fundamental encoding techniques that enable quantum computers to process classical data, as well as essential tools, datasets, and evaluation metrics used in quantum model development. Furthermore, it explores various QML approaches, including supervised, semi-supervised, unsupervised, and reinforcement learning, alongside quantum deep learning (QDL) models such as Quantum Neural Networks (QNNs) and Variational Quantum Circuits (VQCs). The paper also discusses the challenges in QML, including hardware limitations, scalability issues, and the need for improved quantum error correction. A dual-axis taxonomy simultaneously classifies algorithms by learning paradigm and quantum-classical integration level – a structure not found in prior surveys. The survey also covers Quantum Transfer Learning, Quantum Graph Neural Networks, and hardware-aware encoding selection, and introduces the first structured adversarial robustness taxonomy and Explainable QML treatment in a comprehensive QML survey. Together, these contributions position this work as both a reference and a methodological guide for advancing QML research and applications.
Quantum machine learning (QML) is an emerging field combining quantum computing and artificial intelligence, with promising applications in medicine and healthcare. This survey reviews more than 60 studies published between 2018 and 2025, highlighting a sharp increase in research activity, especially in the last three years. We address seven core research questions related to publication trends, the use of real quantum hardware versus simulators, quantum architectures overview, dataset types, medical domains, algorithmic frameworks, and reported results. Our analysis shows that most QML research in healthcare is conducted on simulators due to limited hardware access, and it relies on small datasets. Quantum convolutional neural network (QCNN) architectures dominate image-based medical tasks such as tumor detection, pneumonia diagnosis, and ECG interpretation, while feature-based datasets are mainly analyzed with variational quantum classifiers and quantum support vector machines. Despite hardware constraints, QML models often match or surpass classical machine learning approaches in accuracy, frequently reaching 95–99%. However, these performance statements should be qualified to recognize experimental limitations and avoid excessive optimism and should not be interpreted as definitive proof of quantum superiority at this stage. Additionally, issues with reproducibility and reporting of hardware details persist, which is a significant research gap. This review emphasizes the need for standardized benchmarks, more real hardware testing, and architecture-aware algorithm design. With the potential for accelerated diagnostics and personalized healthcare, QML represents a strategic direction for future medical research.
There has been remarkable development in the data-driven decision-making domain of Artificial Intelligence (AI). However, the complexity of the AI models and the amount of data have shown some drawbacks with conventional computing models. One of the interdisciplinary branches of quantum computing and machine learning is Quantum Machine Learning (QML), which is a combination of quantum computing and machine learning and relies on the unique characteristics of quantum computing, such as superposition, entanglement, and quantum parallelism, to enhance the performance of the machines. This review provides a comprehensive description of theory, architectures, algorithms, implementational approaches, applications, problems, and future directions of QML. The core concepts of quantum computing and machine learning are introduced. Different representations of quantum states, quantum data encoding, variational quantum circuits, quantum kernel methods, and hybrid quantum or classical optimization are discussed. Significant QML algorithms like Quantum Support Vector Machines, Quantum Neural Networks, Variational Quantum Eigen solvers, Quantum Approximate Optimization Algorithms, and Quantum reinforcement learning are explored and evaluated for computational power and applications. The scaling up of quantum computer sizes, data encoding overhead, complexity of optimizations, benchmarking, and decoherence are discussed in detail, as well as recent developments in fault-tolerant quantum computing and hybrid learning approaches. Finally, a conceptual framework is given to demonstrate the unification of classical computation and quantum computation to intelligently process data. This review demonstrates how QML could be the next-generation computational method to accelerate scientific advancements and enable new advanced AI technologies.