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量子生命科学と光 -現状と今後の可能性-

荒牧, 修平, 光利 瀬藤

Published Aug 10, 2020• 0 citations
OpenAlex

Abstract

The advance of quantum technology has been remarkable, and quantum biology has come under the spotlight again in these last few years. Under these circumstances, quantum life science has been established. In this article, we defined quantum life science as being composed of life science, quantum science, and quantum technology. We mainly discussed the present and future possibilities of quantum life science. The momentum for quantum life science has been accelerated all over the world. We tried to introduce promising researches and the Japanese government’spolicy for quantum life science. We also introduced quantum information science, which is related to quantum life science genuinely. In the last part, we discussed that what connection between quantum and life is. We look forward to the future of the new field of quantum life science.

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The advance of quantum technology has been remarkable, and quantum biology has come under the spotlight again in these last few years. Under these circumstances, quantum life science has been established. In this article, we defined quantum life science as being composed of life science, quantum science, and quantum technology. We mainly discussed the present and future possibilities of quantum life science. The momentum for quantum life science has been accelerated all over the world. We tried to introduce promising researches and the Japanese government’spolicy for quantum life science. We also introduced quantum information science, which is related to quantum life science genuinely. In the last part, we discussed that what connection between quantum and life is. We look forward to the future of the new field of quantum life science.
Quantum life science is a rapidly developing interdisciplinary domain that combines concepts from quantum physics with biological sciences to investigate the underlying mechanisms of living systems at the molecular and cellular levels. The principles of quantum mechanics, including quantum tunneling, superposition, and entanglement, are believed to contribute to various biological processes and may help explain phenomena that cannot be fully understood through classical biological models. Studying these quantum effects in living organisms remains difficult because biological environments are highly dynamic and are affected by factors such as decoherence and energy dissipation, which can mask quantum behavior. To overcome these limitations, researchers are employing sophisticated tools and methodologies such as biological nano-scale quantum sensors, quantum-enhanced hyperpolarized MRI and NMR techniques, ultrafast two-dimensional electronic spectroscopy, and advanced computational modeling. The integration of these technologies is accelerating progress in quantum biology and related disciplines. As the field continues to evolve, it offers promising opportunities for advancing knowledge in genetics, molecular biology, medicine, biotechnology, and bioengineering, potentially leading to innovative diagnostic and therapeutic applications.
The initiation of the field ‘quantum biology’ didn’t take too long following the establishment of quantum mechanics during the late 19th century to the early 20th century. In the late 1920s, Bohr delivered a lecture on the possibility of using quantum mechanics in solving the mysteries of life. However, since the 1940s, the field has started getting considerable attention following the publication of Schrödinger’s book on defining life using physics principles. During the last hundred years of research in quantum biology, we have accomplished considerable progress in understanding crucial issues around key biology problems. In this chapter, I shall focus on summarizing most of the areas of biology where the quantum mechanical interventions have helped us understand underlying mechanisms. We could develop some applied technologies involving quantum principles that might be utilized to understand biological diseases and intervene in the associated disorders with appropriate means. A pinpointed historical progression in this novel field of research will mostly be presented. Thus, the information here will help readers and interested researchers understand the field properly and plan for new projects aiming at creating future breakthroughs.
Background: Quantum biology is an emerging interdisciplinary field that explores how principles of quantum mechanics-such as superposition, entanglement, tunneling, and collapse-may influence biological phenomena.Initially speculative, it now offers concrete explanations for complex life processes, prompting a re-evaluation of biology at the quantum scale.Method: This is a narrative review based on an analysis of peer-reviewed literature from indexed journals.Key biological processes were examined in the context of quantum principles.Applications in virology, microbiology, neuroscience, and pharmacology were explored.Discussion: The integration of quantum mechanics into drug discovery and personalized medicine is reshaping therapeutic approaches.Quantum computing promises accelerated simulations of molecular interactions and enzyme dynamics.Quantum dot-based therapies and diagnostics are enhancing precision medicine.The role of superradiance and quantum coherence in neuroprotection, particularly in Alzheimer's disease, is gaining research traction.Techniques such as photodynamic therapy (PDT) and repetitive transcranial magnetic stimulation (rTMS) are being reconsidered through the lens of quantum biology.Conclusion: Quantum biology bridges quantum mechanics and life sciences, offering novel explanations for long-standing biological mysteries.Despite significant experimental challenges-especially in warm, complex biological environments-the field is advancing through ultrafast spectroscopy, cryo-electron microscopy, and quantum simulations.Continued interdisciplinary collaboration and technological innovation are essential to validate these quantum-biological interactions.Ultimately, quantum biology holds the potential to revolutionize our understanding of life, leading to groundbreaking developments in neuroscience, pharmacology, and precision medicine.
Abstract The lines separating Biology and Physics have started to blur in recent decades, leading to the emergence of the interdisciplinary field known as quantum Biology. This field looks into the possibility that basic quantum mechanical phenomena such as coherence, entanglement, tunneling, and superposition play crucial roles in biological processes that are beyond the scope of classical Physics. Biology has traditionally worked within the parameters of classical mechanics, presuming that delicate quantum effects cannot endure in the warm, humid, and cacophonous environments of living systems. But new findings in fields like photosynthesis, olfaction, avian magnetoreception, and enzyme catalysis indicate otherwise, suggesting that living things intentionally and possibly advantageously use quantum principles. From the earliest speculative theories to the most recent experimental confirmations, this book chapter methodically examines the evolution of quantum Biology. We investigate how the exceptionally high energy transfer efficiency in photosynthetic complexes particularly in the light-harvesting proteins of green sulfur bacteria and plants is supported by quantum coherence. The remarkable speed of proton transfers and enzymatic reactions during DNA replication is also investigated in relation to quantum tunneling. The chapter explores magnetoreception in migratory birds and suggests models in which sensitivity to Earth's geomagnetic field is made possible by radical pair mechanisms influenced by quantum entanglement. We also discuss the intriguing but controversial idea that quantum vibrations improve the human olfactory system's capacity for discrimination. In addition to examining particular occurrences, this research challenges more general theoretical models that seek to balance quantum mechanics with the decoherence commonly observed in biological settings. Recent developments in quantum information theory, biomimetic quantum technologies, and ultrafast spectroscopy are highlighted as essential instruments advancing empirical research. We also critically evaluate the field's methodological difficulties, the skepticism of overly optimistic interpretations, and the significant philosophical ramifications of acknowledging life as a quantum phenomenon. In conclusion, quantum Biology suggests that quantum effects are not uncommon aberrations but rather are an essential part of life, offering not only a fresh perspective for reinterpreting well-known biological processes but also the potential for a fundamental paradigm shift. Quantum biology has the potential to completely transform biotechnology, medicine, and our comprehension of consciousness and the origin of life as experimental methods advance. This chapter highlights the significance of interdisciplinary cooperation in order to completely comprehend the latest discoveries and possible future paths of quantum Biology, highlighting its revolutionary influence on our comprehension of life at the most basic levels. Key words: Quantum Biology, tunneling, avian magnetoreception, enzyme catalysis
Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the past decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world-view of quantum coherences, entanglement, and other nonclassical effects, has been heading toward systems of increasing complexity. The present perspective article shall serve as a "pedestrian guide" to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future "quantum biology," its current status, recent experimental progress, and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena.
Quantum biology is an innovative field that blends quantum mechanics and biology to explore how quantum phenomena influence biological processes. This review discusses the fundamental principles of quantum biology, its potential applications in medicine, materials science and energy production, as well as the ethical implications of its progress. By understanding the quantum intricacies of life, we can gain insights into disease mechanisms, develop innovative materials and harness sustainable energy sources. Quantum mechanics, essential for understanding atomic and subatomic behavior, underpins quantum biology, which examines processes like photosynthesis, olfaction and enzyme catalysis. Key principles include superposition, entanglement and tunneling, which may enhance biological efficiency, sensitivity and precision. Quantum biology’s potential spans various fields: in medicine and pharmacy, it could lead to new diagnostic tools and therapies; in materials science, it could inspire quantum materials for electronics, energy storage and sensing; in energy production, it could inform sustainable energy development through photosynthesis insights. However, ethical considerations are crucial. Quantum-enhanced medical technologies might widen healthcare disparities and advanced quantum materials could have mixed societal impacts. Open dialogue and ethical frameworks are necessary for responsible development. The future of quantum biology is promising, with ongoing research and interdisciplinary collaboration expected to yield innovative discoveries, fostering a sustainable and prosperous future. Peer Review History: Received 14 July 2024; Reviewed 19 September 2024; Accepted 16 October; Available online 15 November 2024 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com