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An Experimental Analysis on the Application of Quantum Federated Learning in Healthcare Analytics with Variational Parameter Set-up

D. Jeya Mala, Anto Cordelia Tanislaus Antony Dhanapal, Santhosh D

Published Mar 23, 2026• 0 citations
Publisher

Abstract

The paradigm shift of moving from traditional machine learning models to distributed learning using Federated learning has gained its importance in various real-time applications especially in applications that requires privacy preservation as the primary criterion. However, for complex real-time data, the computational limitations and communication bottlenecks in the current federated learning environment has made the advancements of applying Quantum computing in Federated Learning. Quantum Federated Learning (QFL) is combining FL with Quantum computing. In this paper, QFL is applied for a real-time healthcare analytics dataset to assess the applicability of Quantum computing in such cases. From our implementation, we realized that, even though QFL has several advantages in terms of distributed model training with quantum-based communications, it suffers from accuracy concerns as the current implementation is experimented in the classical system configuration and not in the QPU or Quantum computer set-up. We concluded that, if the Quantum computers or QPU are utilized for such complex real-time dataset, we can get the real advancements QFL.

DOI
10.1051/epjconf/202636001010/pdf

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The paradigm shift of moving from traditional machine learning models to distributed learning using Federated learning has gained its importance in various real-time applications especially in applications that requires privacy preservation as the primary criterion. However, for complex real-time data, the computational limitations and communication bottlenecks in the current federated learning environment has made the advancements of applying Quantum computing in Federated Learning. Quantum Federated Learning (QFL) is combining FL with Quantum computing. In this paper, QFL is applied for a real-time healthcare analytics dataset to assess the applicability of Quantum computing in such cases. From our implementation, we realized that, even though QFL has several advantages in terms of distributed model training with quantum-based communications, it suffers from accuracy concerns as the current implementation is experimented in the classical system configuration and not in the QPU or Quantum computer set-up. We concluded that, if the Quantum computers or QPU are utilized for such complex real-time dataset, we can get the real advancements QFL.
The paradigm shift of moving from traditional machine learning models to distributed learning using Federated learning has gained its importance in various real-time applications especially in applications that requires privacy preservation as the primary criterion. However, for complex real-time data, the computational limitations and communication bottlenecks in the current federated learning environment has made the advancements of applying Quantum computing in Federated Learning. Quantum Federated Learning (QFL) is combining FL with Quantum computing. In this paper, QFL is applied for a real-time healthcare analytics dataset to assess the applicability of Quantum computing in such cases. From our implementation, we realized that, even though QFL has several advantages in terms of distributed model training with quantum-based communications, it suffers from accuracy concerns as the current implementation is experimented in the classical system configuration and not in the QPU or Quantum computer set-up. We concluded that, if the Quantum computers or QPU are utilized for such complex real-time dataset, we can get the real advancements QFL.
Abstract Healthcare organizations have a high volume of sensitive data and traditional technologies have limited storage capacity and computational resources. The prospect of sharing healthcare data for machine learning is more arduous due to firm regulations related to patient privacy. The balanced protection of confidentiality, integrity, and availability of healthcare data, has become a major concern beyond classical data security considerations. In recent years, federated learning offers a solution to accelerate distributed machine learning addressing concerns related to data privacy and governance. Currently, the blend of quantum computing and machine learning has experienced significant attention from academic institutions and research communities. Quantum computers have shown the potential to bring huge benefits to the healthcare sector through efficient distributed training across several quantum nodes. The ultimate objective of this work is to develop a quantum federated learning framework (QFL) to tackle the optimization, security, and privacy challenges in the healthcare and clinical industries for medical imaging tasks. In this work, we proposed federated quantum convolutional neural networks (QCNNs) with distributed training across edge devices. To demonstrate the feasibility of the proposed QFL framework, we performed extensive experiments on medical datasets (Pneumonia MNIST, and CT-kidney disease analysis), which are non-independently and non-identically partitioned among the healthcare institutions/clients. The quantum federated global model maintained a high classification testing accuracy and generalizability and outperformed the locally train clients regardless of how unbalanced the medical data is distributed among the clients. The global model achieved the best performance as compared to local clients in terms of the area under curve of the receiver operating characteristic curve (AUCROC) (0.953) and an average of (0.98) on all classes for predicting outcomes on pneumonia and CT-kidney datasets, respectively. Moreover, the client selection mechanism is proposed to reduce the computation overhead at each communication round, which effectively improves the convergence rate. The proposed quantum federated learning framework is validated and assessed via large-scale simulations. Based on our results from numerical simulations, the deployment of distributed and secure quantum machine learning algorithms for enabling scalable and privacy-preserving intelligent healthcare applications would be extremely valuable.
In the healthcare sector, the scarcity of data and privacy concerns present formidable challenges to the widespread adoption of machine learning. In the present-day scenario, Federated Learning (FL) emerges as a pivotal solution, fostering the rapid evolution of distributed machine learning paradigms while adeptly addressing the problem of data governance and privacy. It allows distributed clients to collaboratively train a global model by synchronizing their local updates without sharing private data. In recent years, federated learning and quantum computing have individually shown great promise to revolutionize various sectors, including healthcare, finance, and manufacturing, where privacy protection is paramount. In this article, we propose a communication-efficient Quantum Federated Learning (QFL) framework based on a variational circuit that enables clients to efficiently train and transmit quantum model parameters, thereby reducing communication rounds significantly and enhancing QFL performance using quantum natural gradient descent (QNGD) optimization. This paper demonstrates the feasibility of a QFL framework for predicting the presence of coronary heart disease, diagnosing whether a patient is suffering from diabetes or not, and differentiating malignant and benign cancer by distributing the UCI datasets unbalanced among healthcare institutions. The proposed framework has the potential to incorporate privacy, security, and the expedited processing of distributed data. QNGD outperformed classical GD by reducing communication rounds by a range of 5% to 60%. In addition to reducing the communication rounds by optimizing the QFL training algorithm and achieving quicker convergence, it also determines the important features regardless of the data imbalance among the clients.
In recent years, the growing demand for secure, efficient, and scalable machine learning has highlighted significant challenges in traditional Federated Learning (FL) systems. These challenges include computational inefficiencies in handling large-scale, high-dimensional data, privacy concerns, and the limitations of classical hardware in solving complex optimization problems. Additionally, the increasing complexity of data and the need for more robust privacy-preserving methods have pushed the boundaries of classical FL. To address these issues, this paper presents a detailed framework for Quantum Federated Learning (QFL), where quantum computing and FL converge to enable distributed quantum model training with enhanced privacy preservation. The system is modeled using local quantum models on clients and a global aggregation strategy at the server. We develop quantum gradient-based optimization with quantum cross-entropy loss, privacy preservation through encryption, and robustness to quantum noise. A set of theorems is provided to prove the correctness and efficiency of the model, supported by rigorous mathematical formulations. We used IBM Qiskit for the simulation and compared our proposed QFL with classical FL. The results demonstrate that our QFL outperformed classical FL in terms of accuracy, precision, recall, and F1 score.
Healthcare organizations have a high volume of sensitive data and traditional technologies have limited storage capacity and computational resources. The prospect of sharing healthcare data for machine learning is more arduous due to government regulations related to patient privacy. In recent years, federated learning has offered a solution to accelerate distributed machine learning addressing concerns related to data privacy and governance. Currently, the blend of quantum computing and machine learning has experienced significant attention from academic institutions and research communities. The ultimate objective of this work is to develop a federated quantum machine learning framework (FQML) to tackle the optimization, security, and privacy challenges in the healthcare industry for medical imaging tasks. In this work, we propose a new methodology based on federated quantum convolutional neural networks (QCNNs) with distributed training across edge devices. To demonstrate the feasibility of the proposed FQML framework, we performed extensive experiments on two benchmark medical datasets (Pneumonia MNIST, and CT kidney disease analysis), which are non-independently and non-identically partitioned among the healthcare institutions/clients. The proposed framework is validated and assessed via large-scale simulations. Based on our results, the quantum simulation experiments achieve performance levels on par with well-known classical CNN models, 86.3% accuracy on the pneumonia dataset and 92.8% on the CT-kidney dataset, while requiring fewer model parameters and consuming less data. Moreover, a client selection mechanism is proposed to reduce the computation overhead at each communication round, which effectively improves the convergence rate.
Abstract The healthcare industry frequently handles sensitive and proprietary data, and due to strict privacy regulations, it is often reluctant to share it directly. In today’s context, Federated Learning (FL) stands out as a crucial remedy, facilitating the rapid advancement of distributed machine learning while effectively managing critical concerns regarding data privacy and governance. The fusion of federated learning and quantum computing represents a groundbreaking interdisciplinary approach with immense potential to revolutionize various industries, from healthcare to finance. In this work, we propose a federated learning framework based on quantum tensor networks (QTNs) that takes advantage of the principles of many-body quantum physics. Currently, there are no known classical tensor networks (TNs) implemented in federated settings. Furthermore, we investigated the effectiveness and feasibility of the proposed framework by conducting a differential privacy analysis to ensure the security of sensitive data across healthcare institutions. Experiments on popular medical image datasets show that the federated quantum tensor network (FedQTNs) model achieved a mean receiver-operator characteristic area under the curve of 91%–98%, outperforming several state-of-the-art federated learning methods. Moreover, QTN models require fewer parameters in FL settings compared to traditional classical models, which often suffer from over-parameterization. This reduction in parameters not only improves the efficiency of the communication process but also significantly decreases data consumption during training. As a result, QTN models facilitate a more effective and resource-efficient approach to training in decentralized environments with limited communication bandwidth. The FedQTN models demonstrate a smaller performance drop even when using strong differential privacy settings, maintaining higher accuracy compared to classical models under similar privacy constraints. Experimental results demonstrate that the quantum federated global model, consisting of highly entangled TN structures, showed better generalization and robustness and achieved higher testing accuracy, surpassing the performance of locally trained clients under unbalanced data distributions among healthcare institutions.