Quantum sensing offers sensitivities surpassing classical limits, yet practical deployment is often constrained by noise and inefficient signal extraction. This systematic review synthesizes literature from 2015 to 2025 and maps the landscape of data-driven signal processing across diverse platforms, including nitrogen-vacancy (NV) centers and cold atom interferometers. Emerging methodologies are categorized and emphasis is placed on the dominance of hybrid quantum-classical architectures where classical machine learning manages high-dimensional data processing while quantum processors execute specific primitives like feature mapping. Our findings demonstrate that advanced statistical frameworks such as Variational Bayesian Inference (VBI) enable scalable multi-parameter estimation with polynomial complexity, allowing dozens of sensor parameters to be estimated within minutes. Meanwhile, quantum sensing missions in GPS-denied navigation have achieved operational gains through AI-automated software designed to manage quantum hardware drifts and environmental noise, despite a persistent reality gap for generalized quantum machine learning. We further analyze the critical sensitivity-robustness dilemma inherent in entangled sensors and discuss mitigation strategies such as covariant quantum error-correcting codes. We also distinguish between theoretical Quantum Fisher Information (QFI) and realized Mean Squared Error (MSE) of sensor outputs to resolve benchmarking inconsistencies in quantum metrology, and propose a "Gold Standard" reproducibility framework tailored for the Noisy Intermediate-Scale Quantum (NISQ) era to promote automated workflows and hardware calibration transparency. This review provides a strategic roadmap for researchers to bridge the gap between theoretical sensitivity and reliable, software-defined operational utility in quantum sensing.
Quantum sensing offers sensitivities surpassing classical limits, yet practical deployment is often constrained by noise and inefficient signal extraction. This systematic review synthesizes literature from 2015 to 2025 and maps the landscape of data-driven signal processing across diverse platforms, including nitrogen-vacancy (NV) centers and cold atom interferometers. Emerging methodologies are categorized and emphasis is placed on the dominance of hybrid quantum-classical architectures where classical machine learning manages high-dimensional data processing while quantum processors execute specific primitives like feature mapping. Our findings demonstrate that advanced statistical frameworks such as Variational Bayesian Inference (VBI) enable scalable multi-parameter estimation with polynomial complexity, allowing dozens of sensor parameters to be estimated within minutes. Meanwhile, quantum sensing missions in GPS-denied navigation have achieved operational gains through AI-automated software designed to manage quantum hardware drifts and environmental noise, despite a persistent reality gap for generalized quantum machine learning. We further analyze the critical sensitivity-robustness dilemma inherent in entangled sensors and discuss mitigation strategies such as covariant quantum error-correcting codes. We also distinguish between theoretical Quantum Fisher Information (QFI) and realized Mean Squared Error (MSE) of sensor outputs to resolve benchmarking inconsistencies in quantum metrology, and propose a "Gold Standard" reproducibility framework tailored for the Noisy Intermediate-Scale Quantum (NISQ) era to promote automated workflows and hardware calibration transparency. This review provides a strategic roadmap for researchers to bridge the gap between theoretical sensitivity and reliable, software-defined operational utility in quantum sensing.
Quantum computing has emerged as a transformative paradigm capable of addressing computational challenges beyond the reach of classical systems.In the current era of Noisy Intermediate-Scale Quantum (NISQ) devices, practical quantum hardware is characterized by limited qubit counts, short coherence times, gate errors, and the absence of full error correction.Despite these constraints, significant progress has been made in developing quantum machine learning (QML) techniques tailored to operate on near-term quantum processors.This paper presents a comprehensive review of Quantum Machine Learning in the context of NISQ computing.We first outline the fundamental principles of quantum computing, including qubits, superposition, entanglement, and quantum parallelism, followed by a detailed discussion of the NISQ computing model and its hardware limitations.The review then examines hybrid quantum-classical learning frameworks, variational quantum algorithms, quantum data encoding strategies, and noise mitigation techniques that enable practical implementation on existing platforms.Emerging applications across healthcare, finance, cybersecurity, climate modeling, and materials science are also surveyed to highlight the real-world potential of QML.Furthermore, key challenges such as scalability, trainability issues, and algorithmic robustness are analyzed, along with current research efforts aimed at overcoming these barriers.The paper concludes by identifying promising future directions for advancing QML toward quantum advantage.This review aims to provide researchers and practitioners with a structured understanding of the capabilities, limitations, and opportunities of quantum machine learning in the NISQ era .
Abstract The arrival of noisy intermediate-scale quantum (NISQ) devices defines an era in which quantum utility is fundamentally constrained by finite coherence times, limited qubit counts, gate infidelities, restricted connectivity, and measurement noise. Within this regime, hybrid quantum-classical frameworks have emerged as the dominant operational paradigm, particularly for quantum machine learning (QML). This review identifies a fundamental trade-off between expressivity, trainability, and noise resilience that governs the performance and scalability of NISQ-era QML systems. To contextualize these challenges, we introduce the resource-constrained iterative routing framework, a hardware-aware conceptual architecture that integrates topology-aware classical compression and distributed quantum orchestration to maintain circuit depths within device-dependent limits while routing representations toward symmetry-constrained Hilbert subspaces to mitigate noise-induced barren plateaus. Furthermore, we shift the discussion of quantum advantage away from asymptotic fault-tolerant complexity toward the notion of operational NISQ advantage based on finite-resource scaling, trainability preservation, and sampling complexity. We evaluate the practical resource efficiency of variational quantum algorithms, quantum kernel methods, and quantum neural networks across superconducting, trapped-ion, neutral-atom, and photonic platforms. The review also examines reproducibility challenges, emphasizing benchmarking against optimized classical baselines, and discusses strategies for managing the sampling overhead of error mitigation alongside distributed execution and quantum circuit compilation. Ultimately, NISQ in Practice positions hybrid QML as a physically constrained computational paradigm while outlining a pathway from contemporary noisy workflows toward early fault-tolerant quantum architectures.
Quantum field theory (QFT)-enabled sensor networks are revolutionizing precision disease detection by exploiting quantum–classical correlations to achieve sensitivity and specificity beyond classical limits. Their diagnostic power, however, depends critically on machine learning (ML) for denoising, fusion, and interpretation of high-dimensional, entangled, and multimodal data streams. This review integrates advances at the ML–QFT interface across four pillars: (i) sensing foundations—NV-diamond and optically pumped magnetometry, cavity optomechanics, and quantum plasmonic or photonic systems; (ii) learning methods—physics-informed preprocessing (e.g., VAEs, diffusion models, PINNs), representation learning for sensor arrays and time series (GNNs, transformers), and hybrid quantum–classical architectures; (iii) applications—ultrasensitive pathogen detection, cancer biomarker profiling, neurodegenerative disease monitoring, and epidemiological surveillance; and (iv) cross-cutting enablers—adaptive calibration, federated and transfer learning, and explainable AI for clinical assurance. A practical ML–QFT co-design framework is presented, mapping model classes to sensor physics and deployment settings (edge/on-sensor versus cloud). An evaluation checklist coupling metrological and ML metrics—limit of detection, SNR uplift, calibration stability, latency, robustness under data shift, and interpretability—is proposed for benchmarking. Literature evidence shows that physics-aligned representations and hybrid learners consistently enhance performance in low-SNR and data-scarce regimes, though challenges remain from decoherence, drift, and scalability. The review concludes with a roadmap toward open benchmarks, quantum-networked distributed sensing, multiscale modeling linking molecular and population data, and certifiable, explainable ML pipelines—positioning ML not just as post-hoc analytics but as a design logic for globally distributed, self-calibrating quantum diagnostic ecosystems.
Quantum Machine Learning (QML) unites quantum computing with modern AI to achieve potential gains in expressivity, runtime, and sample efficiency. This paper synthesizes advances in quantum feature maps, variational quantum circuits (VQCs), and hybrid quantum-classical workflows deployable on noisy intermediate-scale quantum (NISQ) hardware. We outline design principles for data encoding, ansatz selection, and trainability, and summarize error-aware practices—error mitigation, shot-frugal estimation, and compiler co-design. Using synthetic but instructive experiments, we illustrate scaling behavior, noise sensitivity, end-to-end inference latency across backends, and optimizer convergence in variational training. We conclude with an agenda emphasizing domain-aligned encodings, rigorous benchmarking, and reproducible open science to validate advantage beyond asymptotic claims.
The Noisy Intermediate-Scale Quantum (NISQ) era, defined by qubit counts in the hundreds and gate error rates that preclude long coherence times, imposes severe constraints on purely quantum computation. The central problem is that achieving practical quantum advantage for real-world tasks must overcome these hardware limitations, yet fault-tolerant quantum computers with full error correction remain years away. To address this, we present a systematic survey of hybrid classical-quantum computing models, in which classical high-performance resources orchestrate the workflow, perform iterative optimization, and apply error mitigation to noisy quantum processing units. Our review encompasses variational quantum algorithms, such as the variational quantum eigensolver and quantum approximate optimization algorithm; classical optimizers tailored for noisy quantum landscapes; error mitigation techniques including zero-noise extrapolation and probabilistic error cancellation; and circuit knitting that partitions large circuits across small QPUs. We find that these hybrid architectures have already demonstrated domain-specific utility in quantum chemistry for molecular ground-state estimation, in logistics and finance for combinatorial optimization, and in machine learning for generative and recommendation models. Notably, they often surpass purely classical or purely quantum approaches on carefully chosen benchmarks. The evidence indicates that hybrid classical-quantum systems are not a temporary stopgap but a durable paradigm. Their role will persist into the early fault-tolerant era, where small, logical qubits will similarly require classical coordination. Consequently, the field urgently demands the establishment of standardized hybrid performance benchmarks, the maturation of robust quantum-classical middleware capable of efficient transpiration and execution management, and holistic co-design frameworks that seamlessly integrate hardware constraints, software stack layers, and application-specific requirements from the outset.
Quantum computing and artificial intelligence (AI) are converging into a distinct research frontier commonly referred to as quantum-enhanced artificial intelligence, or quantum machine learning (QML). This paper presents a conceptual and integrative review of how principles from quantum physics superposition, entanglement, and interference can be embedded into machine learning pipelines to reshape computational paradigms for classification, optimization, and representation learning. Using a structured narrative-review methodology, the study synthesizes theoretical foundations, algorithmic building blocks (quantum feature maps, variational quantum circuits, quantum kernel methods), and application domains spanning drug discovery, finance, materials science, and natural language processing. The review develops a hybrid quantum-classical architecture model and a complexity-comparison framework contrasting classical algorithms with their quantum counterparts, including Grover's search and Shor's factoring algorithm. Findings indicate that while theoretical speedups are well established, practical quantum advantage on noisy intermediate-scale quantum (NISQ) hardware remains constrained by decoherence, barren plateaus, and limited qubit connectivity. The paper contributes a synthesized taxonomy of quantum-enhanced AI methods and an evidence-based research agenda emphasizing error mitigation, hardware-aware ansatz design, and hybrid workload partitioning. The discussion further situates these developments within the broader trajectory of next-generation computing, arguing that near-term value will accrue primarily through hybrid quantum-classical systems rather than fully quantum pipelines. Implications for researchers, industry practitioners, and policymakers are discussed, alongside limitations inherent to a literature-synthesis approach.