The analysis of data and the development of Quantum Support Vector Machine (QSVM) models for disease classification have rapidly become crucial, commanding significant attention from the research community. Principal Component Analysis (PCA) is a powerful dimensionality reduction technique that effectively eliminates noise and optimizes processing in machine learning applications. When integrated with QSVM, PCA plays an essential role in reducing the number of qubits required and significantly enhancing model performance. In this study, we present a robust breast cancer diagnosis model that seamlessly incorporates PCA into QSVM, clearly demonstrating its effectiveness in improving classification performance on biomedical data compared to traditional methods. Our experimental results decisively show that PCA not only optimizes computational resources but also substantially increases model accuracy, affirming its transformative potential for quantum applications in large-scale data analysis. Our proposed model achieves an exceptional classification accuracy of 98%, unequivocally highlighting the impact of PCA in strengthening QSVM performance for biomedical applications.
The analysis of data and the development of Quantum Support Vector Machine (QSVM) models for disease classification have rapidly become crucial, commanding significant attention from the research community. Principal Component Analysis (PCA) is a powerful dimensionality reduction technique that effectively eliminates noise and optimizes processing in machine learning applications. When integrated with QSVM, PCA plays an essential role in reducing the number of qubits required and significantly enhancing model performance. In this study, we present a robust breast cancer diagnosis model that seamlessly incorporates PCA into QSVM, clearly demonstrating its effectiveness in improving classification performance on biomedical data compared to traditional methods. Our experimental results decisively show that PCA not only optimizes computational resources but also substantially increases model accuracy, affirming its transformative potential for quantum applications in large-scale data analysis. Our proposed model achieves an exceptional classification accuracy of 98%, unequivocally highlighting the impact of PCA in strengthening QSVM performance for biomedical applications.
Quantum Support Vector Machines (QSVMs) have recently emerged as a promising approach for biomedical classification tasks. However, their practical deployment remains constrained by limited qubit availability and sensitivity to high-dimensional feature spaces. This study proposes a hybrid framework integrating Pearson correlation–based feature selection and Principal Component Analysis (PCA) with QSVM for breast cancer diagnosis. First, Pearson correlation analysis is employed to remove redundant and weakly relevant features. Subsequently, PCA projects the selected attributes into a compact subspace while preserving most of the original data variance. This dimensionality reduction strategy decreases the number of qubits required for quantum encoding and improves computational efficiency. Experiments conducted on the Wisconsin Diagnostic Breast Cancer (WDBC) dataset demonstrate that the proposed hybrid QSVM achieves 98% classification accuracy, outperforming or matching existing classical and quantum-based approaches. The results confirm that combining classical preprocessing techniques with quantum classifiers provides a robust and resource-efficient solution for biomedical data analysis.
The application of machine learning has shown significant progress in various fields, including clinical data classification. This study presents a comparative analysis between the classical Support Vector Machine (SVM) and Quantum Support Vector Machine (QSVM) for breast cancer classification using the Wisconsin Diagnostic Breast Cancer (WDBC) dataset. Principal Component Analysis (PCA) was applied as dimension reduction strategy across three configurations (PCA = 2, PCA = 4, and PCA = 6) to evaluate the sensitivity of both models to the feature space dimension. Preprocessing included log1p transformation on 22 skewed features, Manual SMOTE balancing, and MinMaxScaler normalization. SVM was optimized via GridSearchCV (80 parameter combinations, cv = 5), while QSVM employed a ZZFeatureMap quantum kernel (reps = 2, entanglement = full) on qasm_simulator. Experimental results demonstrate that SVM achieved superior accuracy across all configurations, with peak performance at PCA = 6 (Accuracy= 98.83%, AUC = 0.9985, Specificity = 1.0000, Sensitivity = 0.9688, Precision = 1.0000, NPV = 0.9817, and F1-score for malignant = 0.98). QSVM achieved its highest accuracy at PCA = 4 (92.98%), AUC = 0.9622, Sensitivity = 0.9219, Precision = 0.8939, NPV = 0.9524, and F1-score for malignant = 0.91. Across the three PCA configurations, QSVM exhibited a non-monotonic relationship between PCA dimensions and quantum kernel performance . These findings provide a quantitative benchmark for comparing quantum and classical machine learning in breast cancer diagnosis.
Early and accurate diagnosis of breast cancer plays a critical role in improving patient survival rates and reducing treatment costs. Classical machine learning algorithms such as Logistic Regression and Support Vector Machines (SVM) have demonstrated strong performance in medical diagnosis tasks; however, their scalability and representational limits motivate the exploration of emerging paradigms. Quantum Machine Learning (QML), particularly Variational Quantum Classifiers (VQC), has recently gained attention due to its potential to model complex decision boundaries using quantum circuits. This paper presents a comparative analysis between a Variational Quantum Classifier and classical machine learning models for binary breast cancer classification. The study employs dimensionality-reduced clinical data and evaluates model performance using accuracy, confusion matrices, decision boundary visualization, Principal Component Analysis (PCA), and Receiver Operating Characteristic (ROC) curves. Experimental results indicate that the VQC achieves competitive performance with classical approaches, demonstrating its feasibility for small-scale medical datasets and highlighting the promise of quantum-enhanced learning in healthcare applications.
A chronic metabolic disease, diabetes mellitus has become a serious global public health concern. Using the Indian Pima Diabetes Dataset, this study compares Classical Support Vector Machines (CSVM) with Quantum Support Vector Machines (QSVM) for diabetes prediction. To address the challenges associated with high-dimensional data and feature redundancy, before classification, a feature reduction method called Principal Component Analysis (PCA) is used. Experimental results demonstrate that PCA effectively reduces computational complexity while preserving essential information required for classification. Furthermore, the study investigates the potential advantages of quantum-enhanced learning in healthcare prediction tasks by comparing the predictive capabilities and computational characteristics of QSVM against its classical counterpart. The findings provide insights into the applicability of quantum machine learning techniques for medical diagnosis and highlight the opportunities and challenges associated with implementing quantum algorithms on real-world healthcare datasets.
Introduction: In recent years, high-dimensional clinical and genomic data have gained significant importance for prognosis and personalized medicine in breast cancer. But the use of quantum machine learning (QML) on such data is limited by the availability of few qubits, the computation time of quantum simulation, and dimensionality reduction. This work systematically compares several QML architectures for breast cancer classification in the presence of realistic and simulator constraints. Methods: The experiments were performed on a dataset of METABRIC breast cancer patients (2,509 patients). After handling missing values and one-hot encoding, there were 63 features in the processed data set. The feature space was reduced by Principal Component Analysis (PCA) to 12, 4 and 2 components for the implementations of quantum computers, respectively, with 56.10 ± 0.14%, 26.78 ± 0.57% and 16.23 ± 0.33% of the variance retained. Three QML models were tested: Quantum Neural Networks (QNN), Quantum K-Nearest Neighbors (QKNN), and Quantum Support Vector Machines (QSVM), with the models being simulated. Seven classical classification models were tested: Logistic Regression, SVM with RBF kernel, K-Nearest Neighbors, Random Forest, XGBoost, LightGBM and Multilayer Perceptron, both with PCA-matched and full 63-feature representation. All primary results are reported with 5-fold cross validation. Results: Among the evaluated QML architectures, QKNN using 12 principal components achieved the strongest performance, attaining an accuracy of **75.11% ± 3.76%**, an F1-score of **0.7088 ± 0.0433**, and a ROC-AUC of **0.8148 ± 0.0394**. Even though all of the QML models performed significantly poorly in comparison to classical models trained on the entire 63-feature data set, the latter models were able to achieve about **94% accuracy** with XGBoost, Random Forest, and Logistic Regression. The comparison also showed the effect of information loss due to PCA is significant in predictive performance in both classical and quantum models. Discussion: The results show that for high dimensional breast cancer data, currently available simulator-based QML models can learn meaningful patterns with limited quantum resources, but are not as effective as powerful classical machine learning models when complete feature representations are available. The study does not report any sort of quantum advantage or clinical use, but rather a benchmark of current QML architectures that has been rigorously calculated and repeated, with a focus on the impact of dimensionality reduction, validation approaches, and simulator limitations, as well as outlining challenges that need to be overcome prior to practical implementation on real quantum hardware.
Breast cancer, the unruly development of abnormal cells in breasts, is a pressing public health issue and needs early detection for improving survival rates. Machine learning algorithms have shown promising results in breast cancer classification and detection. This study evaluates the performances of traditional and quantum machine learning techniques for data classification of breast cancer, emphasizing their effectiveness in discerning patterns using reduced set of features. An approach is proposed to reduce 30-dimensional features to 2-dimensional features using widely applied Principal Component Analysis (PCA), Incremental PCA, Truncated Singular Value Decomposition and Kernel PCA techniques. This study aims to provide an insight on the impact of reduction of features on the classification of breast cancer using classical and quantum machine learning techniques.