Historically, scientists viewed the human mind as a purely chemical and electrical machine operating under standard thermodynamic laws. This classical model defines the brain as a complex network of biological wires and chemical baths, where all information processing is governed by the predictable, macroscopic movement of ions and molecules. Electrical impulses travel down cellular extensions to trigger the release of neurotransmitters across microscopic gaps, a process that unfolds with the same mechanical reliability as a simple electrical circuit. These interactions occur on a scale of milliseconds and involve millions of atoms moving in bulk, reinforcing the idea that the brain is fundamentally a slow, wet, and noisy system. The immediate consequence of this view is the assumption that all thought can be reduced to simple fluid dynamics and electrical resistance. Such a perspective aligns perfectly with a deterministic universe where large-scale chemical reactions follow predictable, unbreakable rules. Understanding these macroscopic interactions provides the necessary foundation for questioning what happens at much smaller, faster scales within the cell.
Historically, scientists viewed the human mind as a purely chemical and electrical machine operating under standard thermodynamic laws. This classical model defines the brain as a complex network of biological wires and chemical baths, where all information processing is governed by the predictable, macroscopic movement of ions and molecules. Electrical impulses travel down cellular extensions to trigger the release of neurotransmitters across microscopic gaps, a process that unfolds with the same mechanical reliability as a simple electrical circuit. These interactions occur on a scale of milliseconds and involve millions of atoms moving in bulk, reinforcing the idea that the brain is fundamentally a slow, wet, and noisy system. The immediate consequence of this view is the assumption that all thought can be reduced to simple fluid dynamics and electrical resistance. Such a perspective aligns perfectly with a deterministic universe where large-scale chemical reactions follow predictable, unbreakable rules. Understanding these macroscopic interactions provides the necessary foundation for questioning what happens at much smaller, faster scales within the cell.
Over the past decade, discussions of the roles that quantum mechanics might or might not play in the theory of consciousness/mind have become increasingly sharp. One side of this debate stand conventional neuroscientists who assert that brain science must look to the neuron for understanding, and on the other side are certain physicists, suggesting that the rules of quantum theory might influence the dynamics of consciousness/mind. However, consciousness and mind are not separate from matter. Submicroscopic world of the human brain give rise to consciousness, mind. We are never able to make a sharp separation between mind and matter. Thus ultimately there is no “mind” that can be separated from “matter” and no “matter” that can be separated from “mind”. The brain as a mixed physical system composed of the macroscopic neuron system and an additional microscopic system. The former consists of pathway conduction of neural impulses. The latter is assumed to be a quantum mechanical many-body system interacting with the macroscopic neuron system.
Over the past decade, discussions of the roles that quantum mechanics might or might not play in the theory of consciousness/mind have become increasingly sharp. One side of this debate stand conventional neuroscientists who assert that brain science must look to the neuron for understanding, and on the other side are certain physicists, suggesting that the rules of quantum theory might influence the dynamics of consciousness/mind. However, consciousness and mind are not separate from matter. Submicroscopic world of the human brain give rise to consciousness, mind. We are never able to make a sharp separation between mind and matter. Thus ultimately there is no “mind†that can be separated from “matter†and no “matter†that can be separated from “mindâ€. The brain as a mixed physical system composed of the macroscopic neuron system and an additional microscopic system. The former consists of pathway conduction of neural impulses. The latter is assumed to be a quantum mechanical many-body system interacting with the macroscopic neuron system.
Superdeterminism is the concept of a perfectly rigid clockwork universe where every single event, including human thought, was mathematically fixed at the beginning of time. In theoretical physics, this framework posits that the initial boundary conditions of the cosmos dictate the exact evolution of all quantum fields and macroscopic structures without exception. The entire physical system operates as a singular, unfolding equation where particles interact and transfer energy along strictly predefined geometric trajectories. This absolute rigidity is mathematically necessary to preserve the fundamental conservation of information and energy across the spacetime manifold. Just as the precise orbit of a planet can be calculated centuries in advance using gravitational mechanics, the exact firing of a human neuron is equally bound by these inescapable physical laws. By eliminating any possibility of uncaused events, this framework proves that the subjective feeling of making a free choice is merely a biological illusion masking a predetermined mechanical output. Understanding this foundational rigidity requires us to first dismantle the pervasive human belief that randomness exists anywhere in the natural world.
The historical consensus in biophysics has long maintained that the human brain is a strictly classical thermodynamic system, arguing that the “warm, wet, and noisy” biological environment forces rapid quantum decoherence. However, emerging theoretical models and empirical anomalies in quantum biology suggest that macroscopic neural state vectors may actually be driven by underlying quantum correlations. This paper investigates the specific mechanisms—such as microtubule superradiance and Zero-Point Field (ZPF) coupling—that could theoretically preserve and utilize quantum coherence at physiological temperatures. We analyze how sub-nanometer quantum optical effects in tryptophan mega-networks can be deterministically translated into macroscopic action potentials. The results of our theoretical synthesis and computational modeling indicate that while the “Quantum Brain” hypothesis is biologically plausible, its standard ontological interpretation is fundamentally flawed. Proponents frequently appeal to quantum indeterminacy to rescue the metaphysical concept of free will, treating wave function collapse as an uncaused, non-computable choice. By applying the superdeterministic loophole—which violates the assumption of statistical independence—we demonstrate that these quantum biological mechanisms are actually executing pre-correlated hidden variables established at the Big Bang. We conclude that the brain is a deterministic quantum engine, not a random number generator. The subjective experience of conscious agency is reframed as a necessary biological data-compression heuristic, a user interface that masks the relentless, unbroken causal chain of a superdeterministic reality.
In recent decades it has become common throughout the social sciences to think of the human mind simply as a very complex computer. Drawing on an older materialist metaphor of the mind as a machine, the “computational” model of the mind took off after the mid-century invention of the computer and subsequent cognitive revolution in psychology, and has since permeated the social sciences in the form of rational choice and other prominent social theories. The contributions of this model have been huge; but it has always been assumed that the computations going on inside our heads are classical. Quantum brain theory challenges this assumption by proposing that the mind is actually a quantum computer. Classical computers are based on binary digits or “bits” with well defined values (0 or 1), which are transformed in serial operations by a program into an output. Quantum computers in contrast are based on “qubits” that can be in superpositions of 0 and 1 at the same time and also interact non-locally, enabling every qubit to be operated on simultaneously. The idea of a quantum computer was first proposed in the 1980s and is still far from being realized technologically, but it has fired the imagination of scientists by raising the prospect of unimaginable increases in computational power, and other neat tricks besides. If quantum brain theory is true, then our model of the mind would be similarly radically altered, irrespective of the issue of consciousness. Quantum brain theory hypothesizes that quantum processes at the elementary level are amplified and kept in superposition at the level of the organism, and then, through downward causation constrain what is going on deep within the brain. On this view, information from the environment is continuously transformed from the macro- to the micro-level, and then channeled back upward into an “internal quantum state,”
The mind–matter relationship remained in the domain of philosophers for aeons. However, the inquisitiveness of the scientific minds has always been trying to understand the science behind its various functions. The scientific temper ushered in by the Renaissance about the 15th century saw the scientists exploring this problem from a science point of view. Technological advances during the later part of the 20th century enabled neuroscientists to explore and localise functions of the brain. However, the most difficult has been understanding the origin of a conscious experience scientifically or materialistically. Despite the delineation of many functions of the brain, the origin of conscious experience, the qualia, in the material brain remains elusive, so much so it came to be called the holy grail of neuroscience. Heisenberg wrote: ‘Physics entered the domain of philosophy with the emergence of consciousness in quantum observation, which incidentally opened the door for reconciliation of science and philosophy’,[1] an event which enabled the predictions of Snow of the merging of arts and sciences.[2,3] Quantum mechanics is a branch of physics relating to very small particles – subatomic particles – electrons, photons, and everything in the submolecular realm, being the smallest units in matter. Quantum theory is the most fundamental theory of matter available at present. Some basic concepts of quantum physics need to be understood. These include “superposition”, where in subatomic particles exist either as waves or particles in a dual nature, never simultaneously. They exist as waves in more than one place at a time and once an observer observes or interferes with (such as measuring) their superposition state collapses to particle state. Quantum entanglement is the phenomenon that occurs when a group of particles which are generated, interact with or share special proximity such that they remain connected even when separated by vast distances. Consciousness is a manifestation of quantum process. Q mind or Q consciousness comprises a group of hypotheses proposing that quantum mechanical phenomena such as entanglement and superposition may play an important part in the functions of the brain and could thus explain the origin of consciousness. Several theories of quantum consciousness have been proposed. Wigner proposed the idea that quantum mechanics has something to do with the workings of the mind and proposed that the wave function collapse in the interaction with conscious observation creates consciousness.[4] Vitiello and Freeman[5] proposed quantum field theory (QFT) of brain states. This theory deals with systems and provides formal elements from which a standard description of brain activity can be inferred. According to QFT, particles are only excited states or simply manifestations of a field. Every particle has its own field that covers all of the universe, which means that, according to QFT, all of the electrons of the universe belong to the same field and could be regarded as one. Bohm formulated the QFT as a deeper theory of quantum theory plus relativity.[6] He viewed mind and matter as projections into our explicate order underlying the implicate order. Quantum brain dynamics (QBD) hypothesis explains the function of the brain within the framework of QFT.[7] It is not yet known exactly how quantum superpositions and their collapse result in the genesis of the raw feels of consciousness, the qualia. Feynman stated ‘if you think you understand quantum mechanics then you do not!’[8] Pribram proposed the holonomic brain theory (quantum holography). He invoked quantum mechanics to explain the higher-order processing by the mind. Pribram provided evidence on how much of the processes in the brain take place in a distributed fashion.[9,10] The composite model of Pribram-Bohm of holoflux hypothesis addresses observed phenomenon of non-locality both spacially and temporally. Bose and Einstein, who first predicted Bose Einstein condensate proposed that water at dendritic membrane surfaces might operate by structuring condensation,[11] supporting QBD. Penrose and Hamoreff proposed the orchestrated-objective reduction (ORCH-OR) in 1989 through 2013. According to them, the microtubules in the neurons (neurotubules), the tubulin protein polymer at the site of quantum collapse, leads to conscious experience. The quantum superposed states which develop in the tubulins remain coherent and recruit more superposed tubulins until a mass-time-energy threshold is reached. At this point, self-collapse or objective reduction occurs, which is equated to a discrete conscious event. Cascades of ORCH-OR events give rise to the stream of consciousness.[12,13] Penrose suggested that objective reduction represents neither randomness nor algorithmic processing but instead a non-computable influence in spacetime geometry from which mathematical understanding and, by later extension, consciousness derives.[14] Quantum vibrations in the microtubules proposed by Bandyopadhyay[15] have been shown to be source of conscious experience by corroborating the Penrose-Hemeroff’s ORCH-OR hypothesis.[13,16] In April 2022, the results of two related experiments at the University of Alberta and Princeton University, announced at The Science of Consciousness conference, provided further evidence to support quantum processes operating within microtubules. However, in another experiment, Gregory D. Scholes and Aarat Kalra of Princeton University used lasers to excite molecules within tubulins, causing a prolonged excitation to diffuse through microtubules further than expected, which did not occur when repeated under anaesthesia.[17,18] Beck and Eccles considered quantum mechanics at the synaptic level. If Orchestrated objective reduction (ORCH-OR) theory is applicable, a similar phenomenon in the microtubules at the presynaptic level, the axon terminal could be invoked for the genesis of consciousness.[19] A recent study by scientists at Trinity College, Dublin, in October 2022,[20] suggests that quantum processes underlie the cognitive and conscious brain functions. The brain–mind operational architectonics is the boundary between and integration point of quantum physics and eastern metaphysics and that it may inspire building a richer and more inclusive paradigm of the brain–mind relation, where quantum physics and eastern metaphysics are inherently intertwined. A body of empirical evidence[21-24] supports these possibilities, strengthening the proposal that the mind–brain relationship may be partially quantum. Quantum information theory clarifies the distinction between the unobservable mind and the observable brain and supports a solid physical foundation for consciousness research. With all these theories trying to explain and understand the theoretical/hypothetical framework for consciousness to explain the subjective experience of consciousness, the experts of this field feel it is still a long way to bridge the gap between current neurobiological and physical–mathematical concepts with their associated quantum–mind theories. Though there is still a long way to go for explaining conscious experience scientifically, when ever this happens, it will become one of the benchmarks in science. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. Use of artificial intelligence (AI)-assisted technology for manuscript preparation The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the preparation of the manuscript and no images were manipulated using AI.