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IPI Letters

Gravitational Signatures of Biological Information: A Proposed Testing Framework for the Mass-Energy-Information Equivalence Principle

Riam Daou

Published Feb 24, 2026• 0 citations
Publisher

Abstract

The precise physical nature of information remains an open wound on the side of modern physics. While often treated as an abstract mathematical quantity, recent developments in the Mass-Energy-Information Equivalence Principle argue for a more material interpretation: that information carries finite mass. Parallel to this, the field of quantum biology has long wrestled with the possibility of macroscopic coherent states within living systems, most notably through the Orchestrated Objective Reduction hypothesis. This article offers a perspective that attempts to weld these two speculative frameworks into a single, testable prediction. We explore the speculative hypothesis that if biological systems indeed sustain macroscopic quantum coherence, their eventual decoherence must—according to information conservation principles—result in a physical massdefect. Unlike thermal dissipation, which is diffusive and slow, this ”information crash” should theoretically release a sharp, gravitationally detectable transient. Here, we outline the constraints of such an event and propose a conceptual protocol using near-field atom interferometry to isolate this signal from the thermal background. The goal of this perspective is to move the debate on biological information from philosophy into the realm of falsifiable experimental physics.

DOI
10.59973/ipil.331

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The precise physical nature of information remains an open wound on the side of modern physics. While often treated as an abstract mathematical quantity, recent developments in the Mass-Energy-Information Equivalence Principle argue for a more material interpretation: that information carries finite mass. Parallel to this, the field of quantum biology has long wrestled with the possibility of macroscopic coherent states within living systems, most notably through the Orchestrated Objective Reduction hypothesis. This article offers a perspective that attempts to weld these two speculative frameworks into a single, testable prediction. We explore the speculative hypothesis that if biological systems indeed sustain macroscopic quantum coherence, their eventual decoherence must—according to information conservation principles—result in a physical massdefect. Unlike thermal dissipation, which is diffusive and slow, this ”information crash” should theoretically release a sharp, gravitationally detectable transient. Here, we outline the constraints of such an event and propose a conceptual protocol using near-field atom interferometry to isolate this signal from the thermal background. The goal of this perspective is to move the debate on biological information from philosophy into the realm of falsifiable experimental physics.
We present a rigorous derivation of the gravitational field dynamics resulting from the decoherence ofa macroscopic biological quantum state. Operating under the Mass-Energy-Information EquivalencePrinciple, we model the biological system not as a classical assembly of particles, but as a reservoirof bound information mass governed by a specific Equation of State (EOS). We demonstrate thatthe decoherence event—interpreted here as a thermodynamic phase transition from a zero-pressure“information fluid” to a relativistic radiation fluid—induces a discontinuity in the system’s stressenergytensor Tμν. Solving the linearized Einstein Field Equations for this transition, we find thatthe resulting “pressure shock” acts as a source term for a distinct, high-frequency gravitationalpulse. This result implies that the conservation of information necessitates a gravitational signaturedistinct from classical thermal decay, providing a falsifiable prediction for the detection of non-localbiological states via near-field atom interferometry.
We propose a novel experimental protocol to test the conservation of quantum information inmacroscopic biological systems. While standard biological decoherence is modeled as a thermodynamicentropy increase, recent developments in the Orch-OR model and Fr¨ohlich Condensatedynamics suggest that complex biological systems may maintain high-temperature quantum coherencevia topological isolation in microtubule structures. Utilizing the Mass-Energy-InformationEquivalence Principle (Landauer’s Limit), we calculate that the sudden decoherence of a criticallyentangled biological state (N ≈ 1027 qubits) releases a transient pulse of energy with a gravitationalmass equivalent of ∼ 30 ng. We distinguish this ”Information Shockwave” from thermal dissipationby calculating their respective timescales and magnitudes. We present a Near-Field Interferometricdesign (r < 3mm) capable of detecting this anomaly and define a rigorous falsifiability condition todistinguish quantum information conservation from classical heat loss. Update: The rigorous mathematical derivation of this hypothesis, including the stress-energy tensor analysis, has been published here: https://zenodo.org/records/18650313?token=eyJhbGciOiJIUzUxMiJ9.eyJpZCI6IjhiMmZkMDdlLWE2ZTUtNGExOS04NDdlLWJiMDYwZDVkNDY1OSIsImRhdGEiOnt9LCJyYW5kb20iOiI2M2JhNDBiZDRhNzdkYzhkZjY2YzgyZTU4MDAzMmRjZSJ9.0Fm7qAV0W0GRSbcdCfhsNQogxA0BiYnZMlUp86WTxbj0vNlkPothHL_HKTgDbz5H3ECGTTcJ4ZF1GgbaLwS-Lw
This work presents an exploratory conceptual analysis of the possible biophysical implications of fundamental coherence limits arising from gravitational time dilation. The objective is to investigate, at a phenomenological level, whether complex biological processes can operate in regimes sensitive to decoherence mechanisms already predicted by relativistic quantum theory. The study builds upon results established by Pikovski et al. regarding time dilation-induced decoherence, utilizing them exclusively as a background physical limit. No modification or extension of this formalism is proposed. The contribution of the present work consists of examining how such limits might be operationally relevant in the description of non-equilibrium molecular systems, particularly in enzymatic contexts and intracellular dynamics. In this context, we introduce the notion of spectral modulation of the internal energy variance (ΔE\Delta EΔE) as an effective parameter to experimentally test the functional sensitivity of biological systems to these physical limits. The hypothesis is formulated in a falsifiable manner, with suggestions for verification based on time-resolved spectroscopic and structural techniques. The manuscript has an exploratory and interdisciplinary character, situated at the interface between fundamental physics, biophysics, and molecular chemistry, and intends to serve as a starting point for further theoretical and experimental investigations, without claiming the existence of macroscopic quantum coherence in living systems.
We present Biological Quantum Gravitational State Transfer (BQGST), a unified theoretical framework proposing a mechanism for macroscopic quantum teleportation exploiting the intersection of quantum gravity, quantum biology, and quantum information theory. The framework identifies biological systems — specifically microtubules, DNA, cryptochrome proteins, and biophoton emission networks — as naturally evolved quantum gravitational interfaces capable of encoding, transmitting, and reconstructing the complete quantum information pattern of an organism via superposed gravitational fields and entangled spacetime topology. Drawing on Penrose-Hameroff Orchestrated Objective Reduction (Orch-OR), the ER=EPR conjecture (Maldacena & Susskind 2013), the Bekenstein-Hawking holographic entropy bound, and the Bose-Marletto-Vedral (BMV) gravitational entanglement mechanism, BQGST proposes a five-stage transfer protocol. The central contribution is a reframing of the scaling problem: rather than maintaining 10^27 individual atomic quantum states, BQGST encodes and transmits a gravitational information geometry derived from the holographic boundary data of the biological system — reducing the information-theoretic complexity from volumetric to surface-area scaling. Four experimentally testable predictions are presented alongside a formal mathematical treatment of each framework stage.
This article explores the Orchestrated Objective Reduction hypothesis proposed by Roger Penrose and Stuart Hameroff, which posits that human consciousness arises from quantum-mechanical processes within the brain rather than classical algorithmic computation. The author details how tubulin proteins within neuronal microtubules are suggested to function as qubits that sustain quantum superposition and entanglement by isolating signals from environmental decoherence. Gravitational fluctuations are hypothesized to trigger the objective reduction of these quantum states, generating discrete moments of awareness that form a continuous stream of consciousness. Despite theoretical criticisms regarding the weakness of gravitational influences and the prevalence of thermal decoherence, the paper highlights recent experimental evidence in quantum biology, such as sustained photon luminescence in microtubules, that supports the feasibility of long-lasting quantum states in biological structures.
This work presents numerical and theoretical evidence for a testable regime in which semiclassical Schrödinger–Newton dynamics predict a state-dependent gravitational self-interaction in mesoscopic quantum systems. Using large-scale Split-Step Fourier Method (SSFM) simulations, we identify a mass window (≈10⁻¹¹–10⁻¹⁰ kg) where quantum coherence and gravitational self-interaction coexist without immediate decoherence. In this regime, the gravitational self-energy depends smoothly on the spatial structure of the quantum state, leading to a differential phase evolution between superposition states with identical external potentials but different mass-density distributions. The predicted phase signal scales as m² and reaches experimentally relevant magnitudes (Δφ ≈ 10⁻³ rad) for millisecond evolution times, making the effect accessible to next-generation matter-wave and optomechanical interferometry. The work systematically validates the numerical approach, demonstrates energy conservation and convergence of the nonlinear dynamics, identifies a stable “breathing-mode” regime near 10⁻¹⁰ kg, and isolates the gravitational origin of the effect via null tests with the Schrödinger–Newton term removed. This preprint makes no claim regarding spacetime engineering, geometry manipulation, or violations of the equivalence principle. It is explicitly framed as a falsifiable test of semiclassical gravity in a previously inaccessible experimental regime. Confirmation or null detection would provide strong constraints on Schrödinger–Newton–type models and inform the ongoing search for the correct quantum–gravity interface.