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Springer eBooks

Quantum Neural Network for Robust Image Classification: Applications to Medical and Benchmark Datasets

H. Ahmed, Baraa Tantawi, Malak Magdy, Eman Karam Elsayed, Gehad Ismail Sayed

Published Jan 1, 2026• 0 citations
Publisher
DOI
10.1007/978-3-032-07267-2_4

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Noisy-label learning in small-scale medical image classification is challenging and hinders the superiority of deep neural networks. Recent studies suggest that quantum neural networks (QNNs) have shown potential in limited-data regimes, yet their use for noisy-label learning remains under-explored. A key obstacle is QNNs' intrinsic "natural smoothness", which may regularize training but also obscure high-confidence samples needed for noise-transition estimation. We propose Supermartingale-based Label Transition (SLT), an anchor-free loss correction framework for robust QNN-based medical image classification under noisy labels. SLT models entropy reduction in predictive distributions as a supermartingale and uses its monotonic behavior to identify stable transition-matrix refinement steps. This enables dynamic transition updates while reducing noise-driven oscillations during QNN training. We further provide a convergence analysis showing that the proposed transition-refinement process reaches a steady state. Experiments on multiple public small-scale medical image datasets demonstrate that SLT consistently improves QNN-based classification and stably outperforms classic noise-label learning baselines under synthetic and real-world label noise.

arXiv:2607.16293•Jul 13, 2026•0 citations
Classification of medical images plays a vital role in medical image analysis; however, it remains challenging due to the limited availability of labeled data, class imbalances, and the complexity of medical patterns. To overcome these challenges, we propose a novel Hybrid Quantum-Classical Neural Network (HQCNN) for both binary and multi-class classification. The architecture of HQCNN integrates a five-layer classical convolutional backbone with a 4-qubit variational quantum circuit that incorporates quantum state encoding, superpositional entanglement, and a Fourier-inspired quantum attention mechanism. We evaluate the model on six MedMNIST v2 benchmark datasets. The HQCNN consistently outperforms classical and quantum baselines, achieving up to 99.91% accuracy and 100.00% AUC on PathMNIST (binary) and 99.95% accuracy on OrganAMNIST (multi-class) with strong robustness on noisy datasets like BreastMNIST (87.18% accuracy). The model demonstrates superior generalization capability and computational efficiency, accomplished with significantly fewer trainable parameters, making it suitable for data-scarce scenarios. Our findings provide strong empirical evidence that hybrid quantum-classical models can advance medical imaging tasks.
In this work, we investigate the performance of hybrid quantum-classical convolutional neural networks (QCNNs) in medical image classification under the presence of adversarial attacks. Adversarial attacks pose a significant threat to image classification models, since they introduce subtle perturbations to input images, leading to incorrect predictions. Specifically, in this work, 10 QCNNs with their corresponding classic Convolutional Neural Networks (CNNs) counterparts are comparatively examined for their robustness, on two different medical image datasets using transfer learning, under two different adversarial attacks. In a subsequent step, the implementation of training models from scratch is also evaluated. With transfer learning on the X-ray dataset, CNN and QCNN models achieve high and comparable performance across most backbones. On the histopathological dataset, CNNs and QCNNs often generalize worse compared to the X-ray dataset, indicating head overfitting under domain shift. The adversarial evaluation results highlight that most models' robustness comes from the backbone rather than the head. QCNN models perform comparably to CNNs under attack and show improvements when trained from scratch. Overall, the results indicate that integrating quantum circuit mechanisms into classical CNN architectures can enhance the robustness of models in medical imaging tasks, representing a promising domain that warrants further investigation.
Noisy-label learning in small-scale medical image classification is challenging and hinders the superiority of deep neural networks. Recent studies suggest that quantum neural networks (QNNs) have shown potential in limited-data regimes, yet their use for noisy-label learning remains under-explored. A key obstacle is QNNs' intrinsic "natural smoothness", which may regularize training but also obscure high-confidence samples needed for noise-transition estimation. We propose Supermartingale-based Label Transition (SLT), an anchor-free loss correction framework for robust QNN-based medical image classification under noisy labels. SLT models entropy reduction in predictive distributions as a supermartingale and uses its monotonic behavior to identify stable transition-matrix refinement steps. This enables dynamic transition updates while reducing noise-driven oscillations during QNN training. We further provide a convergence analysis showing that the proposed transition-refinement process reaches a steady state. Experiments on multiple public small-scale medical image datasets demonstrate that SLT consistently improves QNN-based classification and stably outperforms classic noise-label learning baselines under synthetic and real-world label noise.