Quantum Machine Learning (QML) is evolving rapidly as improvements in quantum hardware, algorithmic theory, and hybrid quantum-classical software frameworks continue to unfold. Despite the high volume of published research, a set of unresolved challenges has motivated an increasingly critical examination of whether current approaches in QML are genuinely exploit the capabilities of quantum information processing. In this paper, a comprehensive narrative is developed that integrates the latest advances in quantum hardware, foundational principles of QML, methodological developments, present limitations, and emerging directions that will shape the near future of quantum learning. Drawing upon recent experimental milestones, theoretical studies, and applications across healthcare, environmental analytics, and molecular science, this manuscript clarifies where QML stands today and what is required for meaningful progress in the transition toward the fault-tolerant quantum era.
Quantum Machine Learning (QML) is evolving rapidly as improvements in quantum hardware, algorithmic theory, and hybrid quantum-classical software frameworks continue to unfold. Despite the high volume of published research, a set of unresolved challenges has motivated an increasingly critical examination of whether current approaches in QML are genuinely exploit the capabilities of quantum information processing. In this paper, a comprehensive narrative is developed that integrates the latest advances in quantum hardware, foundational principles of QML, methodological developments, present limitations, and emerging directions that will shape the near future of quantum learning. Drawing upon recent experimental milestones, theoretical studies, and applications across healthcare, environmental analytics, and molecular science, this manuscript clarifies where QML stands today and what is required for meaningful progress in the transition toward the fault-tolerant quantum era.
Quantum Machine Learning represents a paradigm shift at the intersection of Quantum Computing and Machine Learning, leveraging quantum phenomena such as superposition, entanglement, and quantum parallelism to address the limitations of classical approaches in processing high-dimensional and large-scale datasets. This survey provides a comprehensive analysis of Quantum Machine Learning, detailing foundational concepts, algorithmic advancements, and their applications across domains such as healthcare, finance, and quantum chemistry. Key techniques, including Quantum Support Vector Machine, Quantum Neural Network, Quantum Decision Trees, and hybrid quantum-classical models, are explored with a focus on their theoretical foundations, computational benefits, and comparative performance against classical counterparts. While the potential for exponential speedups and enhanced efficiency is evident, the field faces significant challenges, including hardware constraints, noise, and limited qubit coherence in the current era of Noisy Intermediate-Scale Quantum devices. Emerging solutions, such as error mitigation techniques, hybrid frameworks, and advancements in quantum hardware, are discussed as critical enablers for scalable and fault-tolerant Quantum Machine Learning systems. By synthesizing state-of-the-art developments and identifying research gaps, this survey aims to provide a foundational resource for advancing Quantum Machine Learning toward practical, real-world applications in tackling computationally intensive problems.
As the limits of classical machine learning (ML) become increasingly evident—especially in terms of computational scalability and data processing—quantum computing emerges as a promising frontier capable of addressing these challenges. Quantum Machine Learning (QML) represents the intersection of quantum computing and traditional ML, aiming to leverage quantum phenomena such as superposition, entanglement, and quantum parallelism to enhance learning capabilities, accelerate training, and solve complex problems that are intractable for classical algorithms. This paper provides a comprehensive overview of the evolving field of QML, beginning with the theoretical foundations of quantum computing and its synergy with classical machine learning principles. We explore key QML algorithms, including quantum support vector machines (QSVM), variational quantum classifiers (VQC), quantum neural networks (QNN), and hybrid quantum-classical approaches that exemplify the practical integration of both paradigms. We further examine real-world applications of QML across domains such as drug discovery, finance, climate modeling, and optimization, where quantum enhancements have begun to show early but promising results. Despite its theoretical potential, QML faces substantial limitations, including quantum hardware instability, limited qubit scalability, noise sensitivity, and unresolved challenges in quantum data encoding and interpretability. In synthesizing recent advancements and persistent obstacles, this paper highlights the importance of continued interdisciplinary research, algorithmic refinement, and hardware evolution. We also outline future directions that could lead QML from experimental promise to practical utility, including developments in quantum error correction, benchmarking standards, and application-specific quantum architectures
Quantum Machine Learning (QML) has emerged as a promising interdisciplinary field that combines quantum computing with machine learning to address complex computational problems. This survey provides a comprehensive overview of the theoretical foundations, unified taxonomy, and key methodologies in QML. We discuss quantum data encoding techniques, variational quantum models, neural-inspired quantum architectures, and quantum data learning approaches, along with their associated challenges and limitations. The survey further examines evaluation strategies, the concept of quantum advantage, and the role of current quantum hardware and software platforms in advancing QML research. In addition, major application domains and the growing importance of trustworthy QML, including interpretability, robustness, and security, are explored. Finally, we highlight open challenges and future research directions to provide insights into the evolving landscape of Quantum Machine Learning.
The rapid advancement of artificial intelligence has positioned Machine Learning (ML) as a cornerstone technology across scientific and industrial domains. In parallel, the emergence of quantum computing has catalyzed a new interdisciplinary field—Quantum Machine Learning (QML)—which promises to transcend the computational barriers faced by classical algorithms. This review paper systematically examines the evolution of ML from foundational statistical models to contemporary transformer architectures, and provides a structured analysis of QML paradigms including variational quantum circuits (VQCs), quantum kernel methods, and quantum neural networks (QNNs). Drawing from 95+ peer-reviewed publications indexed in Scopus and Science Citation Index (SCI) journals—with particular emphasis on 2025–2026 publications in IEEE Access, Nature Communications, Nature Computational Science, and Physical Review Letters—we analyze performance benchmarks, identify hardware constraints, and outline algorithmic innovations shaping the near-term quantum advantage landscape. Our findings indicate that while classical ML retains superiority in large-scale perception tasks, QML demonstrates significant advantages in combinatorial optimization and quantum chemistry simulation. Recent 2025 advances in error mitigation on superconducting qubits and improved VQC barren-plateau mitigation are narrowing this gap rapidly. The paper concludes with a forward-looking research agenda covering fault-tolerant QML, hybrid architectures, and quantum NLP.
Quantum machine learning (QML) has emerged as a transformative paradigm that leverages quantum mechanical phenomena superposition, entanglement, and quantum interference to enhance computational approaches in healthcare. This comprehensive survey systematically examines advances in QML for healthcare applications from 2020 to 2025, analyzing cutting-edge algorithms, recent implementations, and emerging prospects across drug discovery, medical imaging, genomics, and clinical decision support. We review Quantum Support Vector Machines (QSVM), Variational Quantum Circuits (VQC), Quantum Neural Networks (QNN), and hybrid quantum-classical frameworks. Our analysis of 150+ recent publications reveals significant theoretical progress alongside persistent hardware constraints and algorithmic challenges. We provide a comprehensive taxonomy of QML algorithms, a comparative performance analysis against classical baselines, a detailed examination of NISQ-era limitations, and a technology roadmap spanning near-term hybrid approaches through long-term fault-tolerant quantum computing. This survey serves as an updated reference for researchers and practitioners navigating the rapidly evolving intersection of quantum computing and medical informatics.
Abstract The rapid advancement of artificial intelligence has made machine learning (ML) methods central to modern science, technology, and industry. At the same time, the emergence of programmable quantum computers, along with the anticipation of large-scale fault-tolerant machines in the future, has generated interest in the potential of quantum machine learning (QML)—a field that explores quantum properties to enhance ML tasks. While QML is often considered a promising application for quantum computing, its practical advantages over classical methods remain an area of active research and exploration. In recent years, QML has garnered significant global attention, with researchers investigating its potential and limitations. In this chapter, we introduce the fundamentals of QML and provide an overview of recent developments and future trends in the field. We outline potential opportunities where quantum properties might offer advantages in ML tasks while also addressing the open challenges that QML faces in terms of scalability, implementation, and practical utility. We also explore the potential applications of QML in defense and security-sensitive domains. Here, researchers speculate that integrating quantum computing into ML could lead to the development of systems capable of resisting sophisticated threats, such as data manipulation and poisoning. However, realizing these possibilities requires further advancements in both quantum hardware and algorithmic design, making QML a promising yet still evolving field.