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Journal of Neurology Neurosurgery & Psychiatry

246 Feasibility of quantum computing and quantum boltzmann machines for glioblastoma classification

Joseph Davids, Andrew Folusho Alalade, Hutan Ashrafian

Published Nov 26, 2025• 0 citations
Publisher

Abstract

a:2:{s:4:"lang";s:2:"en";s:7:"content";s:1284:" Glioblastoma, one of the most aggressive forms of brain cancer affecting the elderly and children indescriminately requires advanced computational techniques to achieve accurate and efficient classification for improved patient outcomes. This study explores the application of Quantum Boltzmann Machines (QBMs), a quantum-enhanced variant of classical Boltzmann Machines, to classify glioblastoma from multimodal datasets including imaging, spectroscopy, and molecular profiles. QBMs leverage quantum computing’s ability to represent and sample from complex probability distributions, offering a computational advantage in optimizing high-dimensional data. This study demonstrates and presents QBMs and how they may outperform classical models in accuracy and training efficiency, particularly useful for distinguishing glioblastoma from normal and marginal tissues. Preliminary results highlight the potential of quantum-enhanced machine learning to revolutionize cancer diagnostics by enabling faster and more precise classifications. Our future work will involve scaling QBMs to larger datasets, integrating multimodal inputs, and validating performance in clinical workflows, paving the way for quantum technologies in precision oncology. jdavids{at}ic.ac.uk ";}

DOI
10.1136/jnnp-2025-abn.246

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a:2:{s:4:"lang";s:2:"en";s:7:"content";s:1284:" Glioblastoma, one of the most aggressive forms of brain cancer affecting the elderly and children indescriminately requires advanced computational techniques to achieve accurate and efficient classification for improved patient outcomes. This study explores the application of Quantum Boltzmann Machines (QBMs), a quantum-enhanced variant of classical Boltzmann Machines, to classify glioblastoma from multimodal datasets including imaging, spectroscopy, and molecular profiles. QBMs leverage quantum computing’s ability to represent and sample from complex probability distributions, offering a computational advantage in optimizing high-dimensional data. This study demonstrates and presents QBMs and how they may outperform classical models in accuracy and training efficiency, particularly useful for distinguishing glioblastoma from normal and marginal tissues. Preliminary results highlight the potential of quantum-enhanced machine learning to revolutionize cancer diagnostics by enabling faster and more precise classifications. Our future work will involve scaling QBMs to larger datasets, integrating multimodal inputs, and validating performance in clinical workflows, paving the way for quantum technologies in precision oncology. jdavids{at}ic.ac.uk ";}
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Traditional diagnostic procedures often rely on predefined models that may overlook nuanced correlations within patient data. Quantum neural networks, with their ability to represent and process data in a quantum space, provide a more robust framework that can adaptively learn from intricate relationships in patient information. For instance, QNNs can significantly enhance the efficacy of disease detection algorithms, such as those used for identifying early-stage cancers or predicting the onset of chronic conditions like diabetes and heart disease, by offering superior pattern recognition capabilities. Furthermore, QNNs combined with classical machine learning architectures facilitate the creation of hybrid models that harness the strengths of both approaches, leading to diagnostic tools that are not only more precise but also more adaptive to varied data sources. The integration of QNNs with machine learning extends beyond diagnostics to personalized treatment optimization. Traditional treatment planning methodologies, including rule-based and data-driven ML models, often face difficulties in accounting for the multifaceted nature of patient data and individual variability. Quantum neural networks enhance this process by leveraging quantum algorithms that provide an efficient search space for complex treatment optimization problems, allowing for a more detailed understanding of patient responses and potential treatment outcomes. The ability of QNNs to perform parallel processing enables the assessment of a wide range of treatment scenarios simultaneously, leading to more accurate predictions regarding patient reactions to specific drugs, therapies, or medical interventions. This facilitates an adaptive approach that can recommend personalized treatment regimens based on comprehensive patient profiles, ultimately enhancing patient outcomes and reducing the likelihood of adverse drug reactions. In addition to enhancing diagnostics and treatment recommendations, quantum neural networks show promise in forecasting patient outcomes by offering a more robust analysis of longitudinal patient data. Forecasting models that leverage the combined power of quantum and classical algorithms can process historical data more rapidly, allowing healthcare providers to anticipate potential health issues and intervene earlier. For example, predictive models utilizing QNNs can anticipate patient deterioration in critical care settings, facilitating timely interventions that mitigate risks and improve survival rates. Such predictive models can be instrumental in managing chronic diseases, monitoring recovery trajectories, and optimizing resource allocation within healthcare systems, thus contributing to overall efficiency and better resource management. Despite the promising capabilities of integrating QNNs with ML algorithms, there are notable challenges that need to be addressed to fully realize their potential. The practical implementation of quantum algorithms in a healthcare context faces hurdles related to hardware limitations, the need for high fidelity in quantum states, and the scalability of quantum systems to handle real-world clinical data. Additionally, the hybrid nature of combining classical and quantum approaches requires sophisticated algorithms that can bridge the gap between quantum computation and classical data processing pipelines. Solutions to these challenges may include advancements in quantum hardware, such as the development of more stable qubits and noise reduction techniques, as well as the optimization of hybrid algorithms that leverage both classical machine learning and quantum computing capabilities effectively. The exploration of quantum neural networks for healthcare applications also necessitates rigorous ethical considerations, particularly in ensuring data privacy and security. The incorporation of quantum computing must comply with healthcare data protection regulations, and quantum algorithms must be designed to maintain patient confidentiality while processing sensitive health data. Moreover, the interpretability of quantum models poses challenges that could hinder their acceptance in clinical practice. Advances in explainable AI and quantum algorithm transparency are crucial to foster trust among healthcare professionals and patients alike. Integration of quantum neural networks with classical machine learning models represents a transformative approach that could significantly advance healthcare diagnostics, personalized treatment strategies, and patient outcome prediction. By harnessing the computational advantages offered by quantum systems and the flexibility of machine learning algorithms, healthcare applications can achieve a new level of precision and adaptability. Despite current challenges, continued research into quantum algorithms, quantum hardware development, and hybrid computational models promises substantial strides in overcoming these limitations. The synergy between QNNs and ML algorithms could ultimately lead to more effective, personalized, and efficient healthcare solutions, ushering in a new era of data-driven medical care characterized by increased diagnostic accuracy and improved treatment outcomes. As the field evolves, interdisciplinary collaboration between quantum physicists, computer scientists, and healthcare professionals will be vital to unlock the full potential of these innovative computational techniques and bring them to mainstream clinical use.