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Quantum Photonics for Non-Invasive Cancer Diagnostics: A Path Toward Subcellular Imaging Precision

Defne Duman

Published Nov 16, 2025• 0 citations
Publisher

Abstract

Non-invasive cancer diagnostics aim to detect tumors as early as possible without harming the patient. In this project, I explore how quantum photonics can improve medical imaging by using the quantum properties of light to reach subcellular precision. The main idea is to compare classical optical coherence tomography (OCT) with quantum-enhanced imaging that uses single photons, entangled photon pairs, and squeezed-light states. Using a conceptual device model, I examine how quantum light sources could reduce photonic noise, improve contrast, and allow repeated imaging with minimal damage to sensitive tissues. Literature on quantum imaging, biophotonics, and cancer diagnostics is reviewed to connect these ideas to current research in early tumor detection. These studies report gains in axial resolution, depth penetration, and signal-to-noise ratio when quantum effects are used. The project also considers ethical questions, such as fair access, cost, and data privacy, when introducing advanced quantum technologies into healthcare. Overall, the work suggests that quantum photonics can help build safer, faster, and more accurate imaging systems for cancer diagnostics, while supporting responsible and inclusive medical innovation.

DOI
10.62802/797hh044

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Medical imaging, a cornerstone of modern diagnostics that underpins early disease detection and personalized therapy, continues to confront fundamental physical limitations inherent to conventional modalities, including suboptimal sensitivity and specificity, limited resolution, and ionizing radiation risks. Quantum imaging, leveraging principles such as entanglement, superposition, and quantum sensing, has emerged as a transformative paradigm with the potential to transcend these limitations. This review systematically summarizes the physical principles, technological advancements, and major clinical applications of quantum technologies in medical imaging. We elaborate on several cutting-edge modalities, including quantum dot probes for targeted imaging and surgical navigation, wearable magnetoencephalography facilitated by optically pumped magnetometers, quantum-enhanced magnetic resonance imaging with nanoscale resolution, quantum optical coherence tomography with dispersion cancellation, photon-counting computed tomography for superior spectral imaging, and nuclear medicine imaging that can visualize the molecular microenvironment. Additionally, the roles of quantum computing and quantum artificial intelligence in accelerating and optimizing the image analysis workflow are also discussed. Furthermore, we analyze the technical bottlenecks and translational barriers that currently hinder the widespread clinical implementation of these emerging technologies. Finally, we outline promising future research directions to accelerate clinical translation, underscoring the transformative potential of quantum medical imaging to advance precision diagnostics and personalized medicine.