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CRC Press eBooks

Toward Verification of Quantum Brain Dynamics

Akihiro Nishiyama, Shigenori Tanaka, Jack A. Tuszyński

Published Oct 21, 2025• 0 citations
Publisher

Abstract

The aim of this paper is to discuss possible pathways needed to verify quantum brain dynamics (QBD). We begin with the introduction of QBD, involving its history and recent progress in research. We show two scenarios for memory formation in QBD, namely via the emergence of squeezed coherent states and using a holographic mechanism. We provide a strategy to verify QBD by manipulating memory involving our subjective experiences, namely qualia, by adopting control theory. Current conclusions and future perspectives are provided.

DOI
10.1201/9781003455714-7

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Cascades of ORCH-OR events give rise to the stream of consciousness.[12,13] Penrose suggested that objective reduction represents neither randomness nor algorithmic processing but instead a non-computable influence in spacetime geometry from which mathematical understanding and, by later extension, consciousness derives.[14] Quantum vibrations in the microtubules proposed by Bandyopadhyay[15] have been shown to be source of conscious experience by corroborating the Penrose-Hemeroff’s ORCH-OR hypothesis.[13,16] In April 2022, the results of two related experiments at the University of Alberta and Princeton University, announced at The Science of Consciousness conference, provided further evidence to support quantum processes operating within microtubules. However, in another experiment, Gregory D. Scholes and Aarat Kalra of Princeton University used lasers to excite molecules within tubulins, causing a prolonged excitation to diffuse through microtubules further than expected, which did not occur when repeated under anaesthesia.[17,18] Beck and Eccles considered quantum mechanics at the synaptic level. If Orchestrated objective reduction (ORCH-OR) theory is applicable, a similar phenomenon in the microtubules at the presynaptic level, the axon terminal could be invoked for the genesis of consciousness.[19] A recent study by scientists at Trinity College, Dublin, in October 2022,[20] suggests that quantum processes underlie the cognitive and conscious brain functions. The brain–mind operational architectonics is the boundary between and integration point of quantum physics and eastern metaphysics and that it may inspire building a richer and more inclusive paradigm of the brain–mind relation, where quantum physics and eastern metaphysics are inherently intertwined. A body of empirical evidence[21-24] supports these possibilities, strengthening the proposal that the mind–brain relationship may be partially quantum. Quantum information theory clarifies the distinction between the unobservable mind and the observable brain and supports a solid physical foundation for consciousness research. With all these theories trying to explain and understand the theoretical/hypothetical framework for consciousness to explain the subjective experience of consciousness, the experts of this field feel it is still a long way to bridge the gap between current neurobiological and physical–mathematical concepts with their associated quantum–mind theories. Though there is still a long way to go for explaining conscious experience scientifically, when ever this happens, it will become one of the benchmarks in science. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. Use of artificial intelligence (AI)-assisted technology for manuscript preparation The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the preparation of the manuscript and no images were manipulated using AI.

The Journal of Clinical and Scientific Research•Apr 1, 2025•0 citations
The aim of this paper is to discuss possible pathways needed to verify quantum brain dynamics (QBD). We begin with the introduction of QBD, involving its history and recent progress in research. We show two scenarios for memory formation in QBD, namely via the emergence of squeezed coherent states and using a holographic mechanism. We provide a strategy to verify QBD by manipulating memory involving our subjective experiences, namely qualia, by adopting control theory. Current conclusions and future perspectives are provided.
What Quantum Brain Dynamics (QBD) considers is not just these other functions of the brain, this is because they can be well analyzed with the workings of classical mechanics (even though they still play host to a quantum description). It rather considers two specific functions above all else consciousness and memory. QBD falls in line umbrella-covers aspects of the quantum brain analysis such as quantum-consciousness, quantum-mind and quantum-brain. The inspiration that lurks behind the Quantum Interpretation of the Brain (QIB), is traceable to the 1944 article written by E. Schrodinger, What is Life, in which he presents how a living organisms evades decay to equilibrium by the fact of negentropy, as such life which is in its ordered macroscopic state is created (in an environment of disorder), which moves against the second law of thermodynamics. The life that is created, that which is sustained, arises from an interaction that the organism engages in with the environment. This interaction is microscopic, albeit quantum, it is an interaction that underscores the reality of quantum entanglement (which also plays hosts to the superposition of quantum states). The quantum interpretation of the brain is a nascent, yet burgeoning as it might be that necessary tool required for a better articulation and comprehension of the brain.
The question of whether quantum mechanical phenomena play a functional role in brain activity and the emergence of consciousness remains one of the most controversial yet intellectually stimulating debates at the intersection of physics, neuroscience, and philosophy of mind. This review systematically examines the principal theoretical frameworks proposing quantum-level mechanisms in neural computation, including the Orchestrated Objective Reduction (Orch OR) hypothesis by Penrose and Hameroff, the quantum brain hypothesis of Stapp, quantum coherence models in microtubules, and quantum field theories of consciousness. We critically evaluate the current state of empirical evidence—including recent quantum biology findings, the challenge of decoherence in warm, biological systems, and experimental observations of quantum effects in biological systems—alongside computational models that bridge quantum formalism and neural network dynamics. Furthermore, we discuss the implications of quantum cognition models for understanding perception, decision-making, and memory. Despite significant scientific skepticism, emerging evidence from quantum biology and advanced neuroimaging technologies provides tentative support for quantum processes in neural substrates. We conclude by identifying critical gaps in current knowledge and outlining future research directions that may resolve the debate, including proposals for experimental paradigms using quantum sensing technologies applied to neural tissue. This review aims to serve as a foundational reference for researchers across disciplines approaching the quantum mind hypothesis with scientific rigor.
This paper explores the potential of quantum entanglement to revolutionize consciousness computing. We propose a novel computational model predicated on the unique properties of entangled quantum states, specifically aiming to simulate the emergence of consciousness. The core mechanism centers around leveraging entanglement to model the complex interactions within the brain, offering a potential pathway toward understanding and, theoretically, replicating conscious experience. This work investigates the implications of this approach, focusing on generating and simulating the fundamental processes associated with consciousness. We begin by outlining the challenges and opportunities presented by this emerging field, emphasizing the need for rigorous mathematical modeling and theoretical investigation. The paper concludes with a discussion of the potential implications of this research and future directions for investigation.
The physical origin of subjective qualia remains the core hard problem, unexplained by classical neurodynamics or condensed-matter physics. Classical theories only correlate brain activity with experience, leaving an unbridgeable explanatory gap. Existing quantum consciousness models suffer from decoherence vulnerability and lack testable links to neurophysiology. Here, we develop a self-consistent bio-quantum field framework for qualia. We postulate a collective quantum fluctuation field from confined Ca2+^{2+}2+ ions in voltage-gated channels, governed by coupled Hamiltonian and open-system Lindblad decoherence. Under weak-coupling perturbation, we derive an explicit mapping between EEG band power and qualia eigenstates. Biophysical verification confirms femtosecond quantum correlations are thermally viable at physiological temperature. Neural activity regulates quantum dynamics to select qualia eigenstates. This mathematically and biophysically consistent model bridges the explanatory gap, offering a testable quantum framework for the physical basis of consciousness.
I “think together” quantum brain dynamics (QBD) and postmodernism (appropriated to include Heidegger). In particular, the world thrownness of Heidegger, the sovereignty of Bataille and the differance of Derrida can be talked about in terms of QBD. This effects a rapprochement between the QBD revolution against classical neural network brain theory and the postmodern revolution against modernity and the metaphysical tradition. Such a grand millenial rapprochement brings together science in the guise of quantum neurophysics and postmodernism against their respective wills. Discussion of the problem of “consciousness” and brain has been so stalemated and seemingly interminable that if progress is to be made, a great conceptual wrenching is only to be expected. My formulation relinquishes consciousness and the quotidian world-in-common in favor of existence and parallel world-thrownnesses.
The mind–matter relationship remained in the domain of philosophers for aeons. However, the inquisitiveness of the scientific minds has always been trying to understand the science behind its various functions. The scientific temper ushered in by the Renaissance about the 15th century saw the scientists exploring this problem from a science point of view. Technological advances during the later part of the 20th century enabled neuroscientists to explore and localise functions of the brain. However, the most difficult has been understanding the origin of a conscious experience scientifically or materialistically. Despite the delineation of many functions of the brain, the origin of conscious experience, the qualia, in the material brain remains elusive, so much so it came to be called the holy grail of neuroscience. Heisenberg wrote: ‘Physics entered the domain of philosophy with the emergence of consciousness in quantum observation, which incidentally opened the door for reconciliation of science and philosophy’,[1] an event which enabled the predictions of Snow of the merging of arts and sciences.[2,3] Quantum mechanics is a branch of physics relating to very small particles – subatomic particles – electrons, photons, and everything in the submolecular realm, being the smallest units in matter. Quantum theory is the most fundamental theory of matter available at present. Some basic concepts of quantum physics need to be understood. These include “superposition”, where in subatomic particles exist either as waves or particles in a dual nature, never simultaneously. They exist as waves in more than one place at a time and once an observer observes or interferes with (such as measuring) their superposition state collapses to particle state. Quantum entanglement is the phenomenon that occurs when a group of particles which are generated, interact with or share special proximity such that they remain connected even when separated by vast distances. Consciousness is a manifestation of quantum process. Q mind or Q consciousness comprises a group of hypotheses proposing that quantum mechanical phenomena such as entanglement and superposition may play an important part in the functions of the brain and could thus explain the origin of consciousness. Several theories of quantum consciousness have been proposed. Wigner proposed the idea that quantum mechanics has something to do with the workings of the mind and proposed that the wave function collapse in the interaction with conscious observation creates consciousness.[4] Vitiello and Freeman[5] proposed quantum field theory (QFT) of brain states. This theory deals with systems and provides formal elements from which a standard description of brain activity can be inferred. According to QFT, particles are only excited states or simply manifestations of a field. Every particle has its own field that covers all of the universe, which means that, according to QFT, all of the electrons of the universe belong to the same field and could be regarded as one. Bohm formulated the QFT as a deeper theory of quantum theory plus relativity.[6] He viewed mind and matter as projections into our explicate order underlying the implicate order. Quantum brain dynamics (QBD) hypothesis explains the function of the brain within the framework of QFT.[7] It is not yet known exactly how quantum superpositions and their collapse result in the genesis of the raw feels of consciousness, the qualia. Feynman stated ‘if you think you understand quantum mechanics then you do not!’[8] Pribram proposed the holonomic brain theory (quantum holography). He invoked quantum mechanics to explain the higher-order processing by the mind. Pribram provided evidence on how much of the processes in the brain take place in a distributed fashion.[9,10] The composite model of Pribram-Bohm of holoflux hypothesis addresses observed phenomenon of non-locality both spacially and temporally. Bose and Einstein, who first predicted Bose Einstein condensate proposed that water at dendritic membrane surfaces might operate by structuring condensation,[11] supporting QBD. Penrose and Hamoreff proposed the orchestrated-objective reduction (ORCH-OR) in 1989 through 2013. According to them, the microtubules in the neurons (neurotubules), the tubulin protein polymer at the site of quantum collapse, leads to conscious experience. The quantum superposed states which develop in the tubulins remain coherent and recruit more superposed tubulins until a mass-time-energy threshold is reached. At this point, self-collapse or objective reduction occurs, which is equated to a discrete conscious event. Cascades of ORCH-OR events give rise to the stream of consciousness.[12,13] Penrose suggested that objective reduction represents neither randomness nor algorithmic processing but instead a non-computable influence in spacetime geometry from which mathematical understanding and, by later extension, consciousness derives.[14] Quantum vibrations in the microtubules proposed by Bandyopadhyay[15] have been shown to be source of conscious experience by corroborating the Penrose-Hemeroff’s ORCH-OR hypothesis.[13,16] In April 2022, the results of two related experiments at the University of Alberta and Princeton University, announced at The Science of Consciousness conference, provided further evidence to support quantum processes operating within microtubules. However, in another experiment, Gregory D. Scholes and Aarat Kalra of Princeton University used lasers to excite molecules within tubulins, causing a prolonged excitation to diffuse through microtubules further than expected, which did not occur when repeated under anaesthesia.[17,18] Beck and Eccles considered quantum mechanics at the synaptic level. If Orchestrated objective reduction (ORCH-OR) theory is applicable, a similar phenomenon in the microtubules at the presynaptic level, the axon terminal could be invoked for the genesis of consciousness.[19] A recent study by scientists at Trinity College, Dublin, in October 2022,[20] suggests that quantum processes underlie the cognitive and conscious brain functions. The brain–mind operational architectonics is the boundary between and integration point of quantum physics and eastern metaphysics and that it may inspire building a richer and more inclusive paradigm of the brain–mind relation, where quantum physics and eastern metaphysics are inherently intertwined. A body of empirical evidence[21-24] supports these possibilities, strengthening the proposal that the mind–brain relationship may be partially quantum. Quantum information theory clarifies the distinction between the unobservable mind and the observable brain and supports a solid physical foundation for consciousness research. With all these theories trying to explain and understand the theoretical/hypothetical framework for consciousness to explain the subjective experience of consciousness, the experts of this field feel it is still a long way to bridge the gap between current neurobiological and physical–mathematical concepts with their associated quantum–mind theories. Though there is still a long way to go for explaining conscious experience scientifically, when ever this happens, it will become one of the benchmarks in science. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. Use of artificial intelligence (AI)-assisted technology for manuscript preparation The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the preparation of the manuscript and no images were manipulated using AI.