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Communications in computer and information science

Quantum Sensing for Biomedical and Energy Applications

Sivapriya Madhu Pillai, Adarsh Ganesan

Published Oct 19, 2025• 0 citations
Publisher
DOI
10.1007/978-3-032-05144-8_8

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Quantum technology, such as the quantum computers, has attracted significant attention in recent years. In nuclear medicine, powerful and highly sensitive molecular imaging modalities such as PET (Positron Emission Tomography), SPECT (Single Photon Emission CT) and MRI (Magnetic Resonance Imaging) provide accurate morphological and functional information. Exploiting certain aspects of quantum mechanics may bring further improvements in sensitivity, spatial resolution and enable novel capabilities in the field of biomedical imaging and sensing. In this workshop, the possibilities of biomedical applications inspired by quantum technology were discussed. The following exciting topics were covered: quantum entanglement in PET, dynamic nuclear polarization toward more sensitive MRI, quantum sensors based on the229mTh nuclear clock, plans of an advanced high-energy gamma-ray source at CERN, laser-assisted radiation detection, solid-state quantum sensors such as those based on nitrogen vacancy centers in diamond, quantum sensing using cascade multi photons, and a laser-based radioactive isotope analysis.
Quantum optical sensing has evolved from isolated solid state spin defect platforms to increasingly bio-integrated systems designed for biomedical applications. This review presents a perspective on this transition, spanning nitrogen vacancy centers in diamond to emerging fluorescent protein based spin qubits. Advances in diamond fabrication have enabled photonic cavities, nanomechanical resonators, and microstructured devices that enhance spin photon interactions and room temperature sensitivity. Exploration of spin defects in alternative materials further expands the sensing landscape. Parallel progress toward biological compatibility includes chip based architectures for in vitro and in vivo studies, microfluidic integration, and minimally invasive nanodiamond probes capable of intracellular nanothermometry and nanorheometry. Improvements in surface functionalization have enhanced coherence and sensing reliability in complex environments. Collectively, these advances highlight the progress and remaining challenges toward application oriented quantum sensing for the life sciences.
Quantum sensing leverages the properties of quantum systems-such as energy quantization, superposition, and entanglement -to achieve sensitive measurements.[1] Quantum sensors can be based on various platforms, such as photons, cold atoms, solid-state spin qubits, and superconducting circuits, for different applications.Over the last decade, quantum sensing has not only opened new avenues for precision measurement in various scientific domains [2,3] but also made remarkable breakthroughs in biomedical, navigation, energy, and other applications.[4-6] To enhance the benefits of quantum sensing, it is crucial to address challenges related to materials [7] and system engineering [8] to improve sensitivity, reliability, and real-time monitoring.Current research efforts span a diverse range of scientific and technological advancements to address these issues and enable new applications.The Special Issue "Quantum Sensing," edited by Tongcang Li, Renbao Liu, and Chong Zu, features 2 review articles and 13 original articles, reporting the latest advancements in the field.This