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Archives of Razi Institute

Exploring Quantum in Cancer Biology: A Comprehensive Review of Nontrivial Quantum Events

Ali Ayesha, Naeem, Muhammad Yasir, Selamoglu Zeliha, Naqvi, Muhammad Raza

Published Apr 29, 2025• 0 citations
Publisher

Abstract

This study explores the potential of quantum computing as an alternative information processing approach, utilizing quantum bits (qubits), superposition, and entanglement to significantly expand computational capabilities in the healthcare domain. It is evident that quantum mechanics has become a foundational component in the construction of our contemporary physical reality. This scientific field is distinguished by its rapid advancement and the potential to transform various aspects of our daily lives. In this era, quantum biology is of significant importance and has the potential to act as a transformative force, particularly in the field of medicine, specifically in addressing the challenges posed by cancer. Cancer is defined as a complex and abnormal alteration of cells, orchestrated through intricate signaling pathways. This transformation is characterized by the accumulation of deleterious mutations. The concept of phenocopy, representing genetic mutations influenced by the environment, challenges the linear process line of molecular biology involving DNA, RNA, and proteins. Notwithstanding the augmented focus on quantum biology in recent decades, a plethora of unresolved issues persist within the domain of cancer biology, thereby giving rise to unexplored avenues. Quantum theory has demonstrated its ability to explain models related to biological and biochemical processes, encompassing the effects of carcinogens on genes, the mechanism of interactions between chemotherapy drugs and DNA, and the understanding of DNA mutations and defective protein synthesis. Recent skepticism among quantum physicists regarding the fundamental role of quantum effects in biology has emerged, particularly with regard to open quantum systems and the impact of decoherence on the destruction of coherence necessary for significant quantum effects. The document under scrutiny herein undertakes an investigation of recent studies that are rooted in the principles of quantum physics, with a particular focus on the manner in which these principles apply to the domains of cancer biology and metabolism.

DOI
10.32592/ari.2025.80.2.295

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This study explores the potential of quantum computing as an alternative information processing approach, utilizing quantum bits (qubits), superposition, and entanglement to significantly expand computational capabilities in the healthcare domain. It is evident that quantum mechanics has become a foundational component in the construction of our contemporary physical reality. This scientific field is distinguished by its rapid advancement and the potential to transform various aspects of our daily lives. In this era, quantum biology is of significant importance and has the potential to act as a transformative force, particularly in the field of medicine, specifically in addressing the challenges posed by cancer. Cancer is defined as a complex and abnormal alteration of cells, orchestrated through intricate signaling pathways. This transformation is characterized by the accumulation of deleterious mutations. The concept of phenocopy, representing genetic mutations influenced by the environment, challenges the linear process line of molecular biology involving DNA, RNA, and proteins. Notwithstanding the augmented focus on quantum biology in recent decades, a plethora of unresolved issues persist within the domain of cancer biology, thereby giving rise to unexplored avenues. Quantum theory has demonstrated its ability to explain models related to biological and biochemical processes, encompassing the effects of carcinogens on genes, the mechanism of interactions between chemotherapy drugs and DNA, and the understanding of DNA mutations and defective protein synthesis. Recent skepticism among quantum physicists regarding the fundamental role of quantum effects in biology has emerged, particularly with regard to open quantum systems and the impact of decoherence on the destruction of coherence necessary for significant quantum effects. The document under scrutiny herein undertakes an investigation of recent studies that are rooted in the principles of quantum physics, with a particular focus on the manner in which these principles apply to the domains of cancer biology and metabolism.
There is no doubt that quantum mechanics has become one of the building blocks of our physical world today. It is one of the most rapidly growing fields of science that can potentially change every aspect of our life. Quantum biology is one of the most essential parts of this era which can be considered as a game-changer in medicine especially in the field of cancer. Despite quantum biology having gained more attention during the last decades, there are still so many unanswered questions concerning cancer biology and so many unpaved roads in this regard. This review paper is an effort to answer the question of how biological phenomena such as cancer can be described through the quantum mechanical framework. In other words, is there a correlation between cancer biology and quantum mechanics, and how? This literature review paper reports on the recently published researches based on the principles of quantum physics with focus on cancer biology and metabolism.
Abstract The lines separating Biology and Physics have started to blur in recent decades, leading to the emergence of the interdisciplinary field known as quantum Biology. This field looks into the possibility that basic quantum mechanical phenomena such as coherence, entanglement, tunneling, and superposition play crucial roles in biological processes that are beyond the scope of classical Physics. Biology has traditionally worked within the parameters of classical mechanics, presuming that delicate quantum effects cannot endure in the warm, humid, and cacophonous environments of living systems. But new findings in fields like photosynthesis, olfaction, avian magnetoreception, and enzyme catalysis indicate otherwise, suggesting that living things intentionally and possibly advantageously use quantum principles. From the earliest speculative theories to the most recent experimental confirmations, this book chapter methodically examines the evolution of quantum Biology. We investigate how the exceptionally high energy transfer efficiency in photosynthetic complexes particularly in the light-harvesting proteins of green sulfur bacteria and plants is supported by quantum coherence. The remarkable speed of proton transfers and enzymatic reactions during DNA replication is also investigated in relation to quantum tunneling. The chapter explores magnetoreception in migratory birds and suggests models in which sensitivity to Earth's geomagnetic field is made possible by radical pair mechanisms influenced by quantum entanglement. We also discuss the intriguing but controversial idea that quantum vibrations improve the human olfactory system's capacity for discrimination. In addition to examining particular occurrences, this research challenges more general theoretical models that seek to balance quantum mechanics with the decoherence commonly observed in biological settings. Recent developments in quantum information theory, biomimetic quantum technologies, and ultrafast spectroscopy are highlighted as essential instruments advancing empirical research. We also critically evaluate the field's methodological difficulties, the skepticism of overly optimistic interpretations, and the significant philosophical ramifications of acknowledging life as a quantum phenomenon. In conclusion, quantum Biology suggests that quantum effects are not uncommon aberrations but rather are an essential part of life, offering not only a fresh perspective for reinterpreting well-known biological processes but also the potential for a fundamental paradigm shift. Quantum biology has the potential to completely transform biotechnology, medicine, and our comprehension of consciousness and the origin of life as experimental methods advance. This chapter highlights the significance of interdisciplinary cooperation in order to completely comprehend the latest discoveries and possible future paths of quantum Biology, highlighting its revolutionary influence on our comprehension of life at the most basic levels. Key words: Quantum Biology, tunneling, avian magnetoreception, enzyme catalysis
This research investigates the potential role of quantum entanglement in biological information processing. We explore the feasibility of simulating quantum effects within biological molecules and examining the influence of entanglement on fundamental processes such as DNA sequence recognition and protein folding. The core claim centers on demonstrating how entanglement could provide a mechanism for enhanced computational capabilities within biological systems. This work contributes to the emerging field of quantum biology by proposing a novel framework for understanding biological phenomena through the lens of quantum mechanics, specifically focusing on the emergent properties of entanglement. The theoretical analysis presented here lays the groundwork for future experimental investigations and offers a new perspective on the complexities of life.
Quantum microbiology is s trailblazing field that integrates the principles of quantum mechanics with microbial investigation at a fundamental level, redefining our comprehension of microbial functions, at atomic and molecular levels. This arena primarily delves into the quantum phenomena, for instance, superposition, entanglement, and tunneling, that are fundamental to biological processes like enzyme catalysts within microbial cells, transfer of energy in photosynthesis, and electron transport in cellular respiration. By employing quantum physics notions in the domain of microbiology, this approach provides an innovative understanding of the adaptability, efficiency, and survival mechanisms of microbes. The significance of quantum microbiology extends beyond academic curiosity, unveiling possible merits in biotechnology, synthetic biology, and medical sciences. It opens up novel possibilities for designing microbial systems introduced by quantum physics that are more effective for various industries, healthcare, and environmental contexts. As this field advances, it pledges to challenge the existing biological paradigms and deepen our comprehension of the quantum universe. The fusion of quantum with microbiology not only broadens the scope of scientific inquiry but also holds the promise of innovative breakthroughs that could alter multiple dimensions of biotechnology and medicine. This chapter first presents a detailed explanation of quantum mechanics, then quantum biology, and finally explores the realm of quantum microbiology as a frontier of scientific inquiry with the potential to revolutionize our approach to microbial research and biotechnology.
To date, classical deterministic Newtonian physics has been used by biologists to describe living processes. However, it is increasingly appreciated that the probabilistic view offered by quantum mechanics more accurately describes the behavior of atoms and materials in all systems. Here, we discuss how the concepts of quantum mechanics can be applied to biological processes involved in cancer. We present a concise summary inspired by Heisenberg's Uncertainty Principle to describe our «Genetic Environmental Field Hypothesis». Combining the uncertainties of genetic changes as expressed by epigenetic changes and/or somatic mutations with the uncertainties of environmental changes, cells may become cancerous as a way to increase entropy. Throughout the paper we will utilize the H19 gene system as an example. Using the concepts of quantum mechanics to describe oncological processes may provide novel directions in our understanding of cancer.
Quantum life science is a rapidly developing interdisciplinary domain that combines concepts from quantum physics with biological sciences to investigate the underlying mechanisms of living systems at the molecular and cellular levels. The principles of quantum mechanics, including quantum tunneling, superposition, and entanglement, are believed to contribute to various biological processes and may help explain phenomena that cannot be fully understood through classical biological models. Studying these quantum effects in living organisms remains difficult because biological environments are highly dynamic and are affected by factors such as decoherence and energy dissipation, which can mask quantum behavior. To overcome these limitations, researchers are employing sophisticated tools and methodologies such as biological nano-scale quantum sensors, quantum-enhanced hyperpolarized MRI and NMR techniques, ultrafast two-dimensional electronic spectroscopy, and advanced computational modeling. The integration of these technologies is accelerating progress in quantum biology and related disciplines. As the field continues to evolve, it offers promising opportunities for advancing knowledge in genetics, molecular biology, medicine, biotechnology, and bioengineering, potentially leading to innovative diagnostic and therapeutic applications.