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Frontiers in Oncology

Evaluation of quantum contouring algorithms for treatment planning on MR abdominal images

Rachel Glenn, Tucker Netherton, Adrian Celaya, Mohamed Eltaher, Beatrice M. Rivière, Eugene Jon Koay, David Fuentes

Published Aug 6, 2025• 0 citations
Publisher

Abstract

Introduction: Quantum computing is increasingly being investigated for integration into medical radiology and healthcare applications worldwide. Given its potential to enhance clinical care and medical research, there is growing interest in evaluating its practical applications in clinical workflows. Methods: We developed an evaluation of quantum computing-based auto-contouring methods to introduce medical physicists to this emerging technology. We implemented existing quantum algorithms as prototypes tailored for specific quantum hardware, focusing on their application to auto-contouring in medical imaging. The evaluation was performed using a medical resonance imaging (MRI) abdominal dataset, comprising 102 patient scans. Results: The quantum algorithms were applied to the dataset and assessed for their potential in auto-contouring tasks. One of the quantum-based auto contouring methods demonstrated conceptual feasibility, practical performance is still limited by current available quantum hardware and scalability constraints. Discussion: Our findings suggest that while quantum computing for auto-contouring shows promise, it remains in its early stages. At present, artificial intelligence-based algorithms continue to be the preferred choice for auto-contouring in treatment planning due to their greater efficiency and accuracy. As quantum hardware and algorithms mature, their integration into clinical workflows may become more viable.

DOI
10.3389/fonc.2025.1553539

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Introduction: Quantum computing is increasingly being investigated for integration into medical radiology and healthcare applications worldwide. Given its potential to enhance clinical care and medical research, there is growing interest in evaluating its practical applications in clinical workflows. Methods: We developed an evaluation of quantum computing-based auto-contouring methods to introduce medical physicists to this emerging technology. We implemented existing quantum algorithms as prototypes tailored for specific quantum hardware, focusing on their application to auto-contouring in medical imaging. The evaluation was performed using a medical resonance imaging (MRI) abdominal dataset, comprising 102 patient scans. Results: The quantum algorithms were applied to the dataset and assessed for their potential in auto-contouring tasks. One of the quantum-based auto contouring methods demonstrated conceptual feasibility, practical performance is still limited by current available quantum hardware and scalability constraints. Discussion: Our findings suggest that while quantum computing for auto-contouring shows promise, it remains in its early stages. At present, artificial intelligence-based algorithms continue to be the preferred choice for auto-contouring in treatment planning due to their greater efficiency and accuracy. As quantum hardware and algorithms mature, their integration into clinical workflows may become more viable.
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Quantum Machine Learning (QML) is an emerging, powerful paradigm at the intersection of quantum computing and artificial intelligence, with the potential to enhance medical image analysis. We compared their performance with classical counterparts, while critically examining the gap between theoretical quantum advantages and the practical constraints of current Noisy Intermediate-Scale Quantum (NISQ) implementations. This review explored the current landscape of QML-based methodologies applied to key medical imaging modalities - Magnetic Resonance Imaging (MRI), Computed Tomography (CT), X-rays, and histopathology. We systematically analyzed how quantum-enhanced models were employed for critical tasks such as image classification, segmentation, and reconstruction, and we compared their performance with that of classical counterparts. The review delved into the architectural innovations that enabled these quantum approaches, including hybrid quantum-classical frameworks, variational quantum circuits, and quantum convolutional neural networks. Particular emphasis was given to the clinical relevance of QML applications, from early diagnostics to real-time surgery planning, and how quantum advantage might influence data efficiency, interpretability, along computational scalability. Finally, we highlighted current challenges in data encoding, noise resilience, and hardware limitations, and discussed promising future directions that could enable the practical deployment of QML in healthcare settings. This comprehensive review aimed to serve as a foundational reference for researchers and practitioners looking to harness quantum computing in medical imaging and precision medicine.
Abstract The convergence of quantum computing and medical image analysis has emerged as a promising frontier for advancing diagnostic intelligence beyond the limits of classical machine learning. Recent developments in quantum hardware and quantum machine learning (QML) algorithms have stimulated growing interest in their potential to enhance complex medical imaging tasks, including disease classification, image segmentation, and clinical decision support (Wei et al., 2023; Ullah and Garcia-Zapirain, 2024). This study presents a comprehensive review and synthesis of state-of-the-art QML methodologies applied to medical imaging, systematically examining both theoretical foundations and empirical implementations. We analyze quantum-based and hybrid quantum–classical models employed across modalities such as MRI, CT, X-ray, and histopathological imaging, with particular attention to classification accuracy, computational efficiency, and diagnostic robustness (Maheshwari et al., 2022; ElBedoui et al., 2025). Our findings reveal clear trends indicating that hybrid quantum–classical approaches currently dominate practical applications, consistently outperforming purely classical baselines in select low-dimensional and domain-specific diagnostic tasks. Performance gains are most evident in feature-rich yet data-constrained scenarios, where quantum kernels and variational circuits demonstrate enhanced representational capacity (Ajlouni et al., 2023; Landman et al., 2022). However, these advantages remain context-dependent and sensitive to noise, circuit depth, and encoding strategies. Overall, QML holds significant promise for improving medical image-based diagnosis, but its widespread clinical adoption is constrained by hardware scalability, limited qubit coherence, and unresolved data encoding challenges. Addressing these limitations will be critical for translating QML from experimental feasibility to routine medical practice (Marengo and Santamato, 2025; Rawas and AlSaeed, 2026).
Introduction: This review examines quantum computing (QC) applications in clinical care, emphasizing advancements directly impacting patient outcomes. QC holds transformative potential in medicine, particularly through enhancing diagnostic accuracy, optimizing treatment plans, and enabling real-time decision-making. Methods: A systematic analysis of 35 studies published between 2015 and 2024 was conducted. The studies were evaluated for their contributions to diagnostic, therapeutic, and decision-support improvements in clinical care enabled by quantum computing technologies. Results: The analysis revealed QC's promise in improving diagnostic accuracy in medical imaging, optimizing treatments in oncology, and enhancing real-time clinical decision-making. QC-driven algorithms demonstrated potential to enhance diagnostic accuracy and computational efficiency. These improvements could enable earlier detection of diseases such as Alzheimer's, cancer, and osteoarthritis, supporting more timely interventions and better prognoses. Discussion: Despite promising outcomes, current limitations-such as hardware scalability, error mitigation, and ethical considerations-hinder widespread adoption of QC in clinical settings. Overcoming these challenges will require interdisciplinary collaboration and technological innovation. The review underscores QC's capacity to deliver precise, personalized, and efficient care, advocating for its integration into healthcare workflows to advance precision medicine and improve patient outcomes.
Quantum computing with AI-driven medical technologies represents an absolute frontier of transformation in precision medicine, diagnostics, and drug discovery. This chapter explores the intersection of quantum computing and artificial intelligence in transforming complex medical challenges, namely in big data analysis, acceleration in molecular simulations, and personalizing treatment plans. Quantum algorithms can scale exponentially beyond AI's capabilities in the breakthrough of genomic analysis, radiological interpretation, and predictive modeling for patient outcomes. The focus of the chapter will be on state-of-the-art achievements in quantum machine learning, possible applications in healthcare areas, and their future prospects for the revolutionizing of medical imaging, optimization of clinical trials, and real-time data processing on wearable devices. They confront the computational limits of classical systems and offer new ground for significant progress in both medical research and health care delivery by solving problems that have until now been intractable.
Quantum computing is quickly revolutionizing medicine, promising unprecedented levels of processing, analysis, and decision-making abilities. This review discusses recent developments in applying quantum computing to medical imaging, diagnostics, and treatment planning. Quantum machine learning and hybrid quantum-classical models have been used by researchers to show improved accuracy, speed, and scalability in medical image classification, segmentation, and disease prediction. Quantum-improved algorithms are being implemented for early detection of multifactorial diseases like cancer and neurologic disorders with potential for advancing clinical prognoses and biomarker discovery. Moreover, quantum cryptography methods are under development to enhance security for private medical information with concerns regarding expanding privacy and security risks. Improvements in quantum neural networks and adaptive hybrid quantum convolutional neural networks (CNNs) also hold promise in enhancing diagnostic efficiency and resource savings. This review synthesizes existing applications, identifies new trends, and delineates challenges and future directions of quantum computing in medicine. It underscores the importance of explainable and interpretable quantum AI systems to maintain clinical trust and utility. The results indicate that quantum technologies, although in their infancy, have transformative potential for precision medicine, personalized therapy, and sophisticated medical decision-making.