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Advanced Quantum Technologies

Quantum Artificial Intelligence Scalability in the NISQ Era: Pathways to Quantum Utility

Giuliana Siddi Moreau, Lorenzo Pisani, Manuela Profir, Carlo Podda, Lidia Leoni, Giacomo Cao

Published May 28, 2025• 15 citations
Publisher

Abstract

Abstract Quantum computing has immense potential to advance the field of Artificial Intelligence (AI), promising faster processing, better optimization, and the ability to handle complex data structures more effectively. However, several challenges need to be addressed, including hardware limitations, algorithm development, and integration with existing AI workflows. This work provides a comprehensive overview of the current state of quantum AI research, covering key areas such as quantum machine learning, quantum deep learning, quantum natural language processing, quantum problem solving, quantum fuzzy logic, quantum evolutionary computation, and quantum decision making. It also presents a collection of interesting use cases targeted at different vertical sectors. The research methodology involves a thorough literature review to capture the most impactful developments from the standpoint of algorithm scalability in the 2020–2024 timeframe. The review highlights the benefits of quantum approaches, such as improved learning capacity, robustness to overfitting and, in some specific cases, quantum speedups for solving various problems. The interdisciplinary research landscape demonstrates a discernible trajectory toward the implementation of practical, large‐scale quantum computational intelligence. This progression is contingent upon the adoption of scalable algorithms that can deliver a quantum advantage, diverging from the replication of classical AI workflows.

DOI
10.1002/qute.202400716

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Abstract Quantum computing has immense potential to advance the field of Artificial Intelligence (AI), promising faster processing, better optimization, and the ability to handle complex data structures more effectively. However, several challenges need to be addressed, including hardware limitations, algorithm development, and integration with existing AI workflows. This work provides a comprehensive overview of the current state of quantum AI research, covering key areas such as quantum machine learning, quantum deep learning, quantum natural language processing, quantum problem solving, quantum fuzzy logic, quantum evolutionary computation, and quantum decision making. It also presents a collection of interesting use cases targeted at different vertical sectors. The research methodology involves a thorough literature review to capture the most impactful developments from the standpoint of algorithm scalability in the 2020–2024 timeframe. The review highlights the benefits of quantum approaches, such as improved learning capacity, robustness to overfitting and, in some specific cases, quantum speedups for solving various problems. The interdisciplinary research landscape demonstrates a discernible trajectory toward the implementation of practical, large‐scale quantum computational intelligence. This progression is contingent upon the adoption of scalable algorithms that can deliver a quantum advantage, diverging from the replication of classical AI workflows.
The field of Quantum Artificial Intelligence (Quantum AI) has emerged as a promising interdisciplinary research area where the computational power of quantum computing is merged with the learning and decision-making power of AI. The application of quantum principles such as superposition, entanglement and quantum interference to machine learning algorithms has created new possibilities for solving problems that may be difficult to solve by classical machines. In the last few years, advances in Noisy Intermediate-Scale Quantum (NISQ) devices have helped to speed advances in Quantum Machine Learning (QML) algorithms, Quantum Neural Networks (QNNs), Quantum Support Vector Machines (QSVMs), Quantum Convolutional Neural Networks (QCNNs) and hybrid learning algorithms. This review provides a comprehensive overview of the research in the field of Quantum AI from 2020 to 2026, covering the key concepts, novel architectures, algorithmic advancements, and practical applications. A critical assessment of the application of Quantum AI in fields such as healthcare, finance, cybersecurity, scientific computing and optimization problems is provided, and the benefits of quantum-enhanced learning models are discussed. In addition, common difficulties such as quantum hardware limitations, sensitivity to noise, encoding of data, scalability constraints and a lack of speed in training variational quantum circuits are discussed. The review also covers new avenues of research, including trustworthy quantum machine learning, explainable Quantum AI, quantum federated learning, and fault-tolerant quantum computing. The results suggest while practical large-scale deployment is currently limited by existing hardware capabilities, hybrid quantum-classical systems have great potential to rapidly move intelligent data processing and develop next-generation AI systems.
Quantum computing and artificial intelligence (AI) are two rapidly evolving technologies poised to redefine the future of computation and decision-making.The two fields unite under the name Quantum Artificial Intelligence (QAI) or Quantum Intelligence, which enables a transformative approach to problem-solving through the fusion of AI mental functions with quantum computing capabilities.This paper provides a comprehensive review of the current landscape, highlighting the opportunities and challenges in integrating quantum computing with AI systems.The research investigates current developments in quantum machine learning, quantum neural networks, and hybrid quantum-classical systems, which show promise for achieving rapid performance improvements and enhanced scalability and data processing capabilities.At the same time, it identifies critical barriers, including hardware limitations, algorithmic complexity, data encoding issues, and the lack of standardization in frameworks.The review further explores future directions, including the role of explainable AI, error correction, and interdisciplinary research in achieving practical quantum-AI synergy.By analyzing both the technological potential and the practical constraints, this paper aims to outline a roadmap for advancing quantum intelligence as a transformative force in next-generation computational paradigms.
Quantum Artificial Intelligence (Quantum AI) embodies the integration of quantum computational paradigms with artificial intelligence frameworks to address the computational intractability and scalability constraints inherent in classical AI systems. By leveraging quantum mechanical properties such as superposition, entanglement, and quantum interference, Quantum AI enables enhanced representation learning, accelerated optimization, and improved probabilistic inference in high-dimensional problem spaces. In parallel, deep-tech innovations—including advanced deep learning architectures, neuromorphic computing, and edge-based intelligent processing—are redefining the architectural foundations of next- generation intelligent systems through energy-efficient, adaptive, and real-time computation. This paper presents a technically rigorous and comprehensive review of Quantum AI and deep-tech innovations, focusing on algorithmic formulations, architectural models, and system-level integration strategies. Core methodologies such as quantum machine learning algorithms, parameterized quantum circuits, variational quantum algorithms, and hybrid quantum–classical optimization frameworks are critically analysed with respect to computational complexity, repressibility, and feasibility on noisy intermediate-scale quantum (NISQ) hardware. Additionally, the role of neuromorphic computing in enabling spiking neural architectures and event-driven processing is examined as a complementary paradigm to quantum-enhanced learning models, particularly for low-power and latency-critical applications. The paper further investigates application- driven deployments of Quantum AI across domains including medical diagnostics, cryptographic security, autonomous decision-making, and smart cyber-physical systems, highlighting performance trade-offs and implementation constraints. Key challenges such as quantum noise, decoherence, data encoding bottlenecks, limited qubit connectivity, and ethical governance are systematically discussed. Finally, future research directions are identified, emphasizing fault-tolerant quantum learning architectures, scalable hybrid integration with deep-tech systems, and co-design methodologies for realizing practical next-generation intelligence platforms.
Quantum computing is emerging as a powerful computational paradigm capable of solving infeasible problems for classical computers. This review explores the intersection of quantum computing and artificial intelligence (AI), focusing on how quantum algorithms can enhance AI applications. The purpose of this review is to provide a comprehensive analysis of current advancements in quantum machine learning (QML), quantum optimization, and quantum neural networks, highlighting their implications for data processing, cryptography, and decision-making systems. The scope of the literature includes peer-reviewed articles, conference papers, and technical reports from 2020 to 2025, focusing on quantum algorithms, applications in AI, and hardware limitations. Key findings indicate that quantum computing can significantly accelerate data processing tasks, optimize complex problem-solving techniques, and improve the efficiency of AI models. However, challenges such as quantum noise, error correction, and hardware scalability remain substantial barriers to widespread adoption. This review concludes with discussing future research directions, including hybrid quantum-classical systems and advanced quantum error correction methods. This study serves as a foundational reference for researchers and practitioners aiming to leverage quantum computing for AI-driven applications. 3. Keywords Quantum Computing, Artificial Intelligence, Quantum Machine Learning, Quantum Algorithms, Data Processing, Optimization, Quantum Neural Networks
Abstract This review aimed to explore the integration of Quantum Computing (QC) with Artificial Intelligence (AI) subsets such as Machine Learning (ML) and Deep Learning (DL), addressing the computational demands posed by the exponential growth of visual data. It identifies key challenges such as interdisciplinary complexity, lack of standard benchmarks, scalability, integration barriers, and the theoretical-practical gap in quantum applications. The review systematically examines existing literature on the application of quantum algorithms in areas including image processing, Natural Language Processing (NLP), Transfer Learning (TL), Federated Learning (FL), networking, cybersecurity and the finance sector. It highlights the usage of quantum principles like superposition and entanglement to accelerate computations, optimize models, and enhance data security in ML/DL frameworks. Findings indicate that integrating QC with ML/DL offers faster convergence, improved optimization, secure decentralized learning, and efficient handling of large-scale and complex data. Specific improvements are observed in TL and FL approaches, NLP accuracy, cryptographic robustness, and performance in medical diagnostics and autonomous systems. QC holds transformative potential in enhancing ML/DL capabilities across domains. Despite existing challenges such as error mitigation and integration complexity, its combination with classical learning methods opens new frontiers for research in AI-driven sectors. Future studies should focus on bridging theoretical and application-level gaps while creating standardized evaluation frameworks.
Quantum Computing (QC) and Artificial Intelligence (AI) have emerged as key technologies in the evolution of Industry 6.0, driving advancements in automation and advanced analytics, and process optimization. Their integration holds the potential to revolutionize sectors such as data science, healthcare, finance, and cybersecurity by enabling faster and more efficient computations through qubits, superposition, and quantum entanglement. However, the lack of structured knowledge regarding specific QC methodologies and applications in AI hinders its optimal implementation and development. Consequently, this study aims to identify the applications and variables associated with QC-AI integration. To this end, a systematic literature review was conducted following the PRISMA 2020 methodology, drawing on studies from Scopus and Web of Science databases. This enabled the analysis of trends, limitations, and opportunities in this technological convergence. This study aims to systematically examine the intersection of quantum computing and artificial intelligence by identifying the key technological features, integration requirements, and sectoral applications that define the current state of the field. The review contributes by mapping existing research, highlighting methodological approaches, and revealing gaps that may guide targeted advancements in hybrid quantum AI systems. The insights generated have the potential to accelerate innovation in high-impact domains such as healthcare, finance, energy, and cybersecurity. The findings indicate that the main advances in QC applied to AI focus on quantum optimization, Quantum Machine Learning (QML), and post-quantum cryptography. Notably, sectors such as energy, healthcare, and finance have shown significant progress in adopting these technologies. For example, in healthcare, QML has been applied to simulate molecular interactions to accelerate drug discovery, and in finance, it enhances predictive models for market behavior. The study concludes that although QC demonstrates substantial potential to enhance AI, its broader adoption remains constrained by reliance on NISQ hardware, the need for effective error correction, and the limited scalability of hybrid quantum classical algorithms. Addressing these challenges will be essential to establishing QML as a cornerstone of technological innovation and digital transformation. Additionally, this review introduces an integrative framework that categorizes key AI QC convergence dimensions and proposes a classification of application areas based on technical requirements and algorithmic capabilities. These contributions aim to guide future experimental validations and hybrid model development.