The class imbalance of electrocardiogram (ECG) data is a serious impediment to the development of diagnostic systems for heart disease. To address this issue, this paper proposes HQ-DCGAN, a hybrid quantum deep convolutional generative adversarial network, specifically designed for the generation of ECGs. The proposed algorithm employs different quantum convolutional layers for the generator and discriminator as feature extractors and utilizes parameterized quantum circuits (PQCs) to enhance computational capabilities, along with the model-feature mapping process. Moreover, this algorithm preserves the nonlinearity and scalability inherent to classical convolutional neural networks (CNNs), thereby optimizing the utilization of quantum resources, and ensuring compatibility with contemporary quantum devices. In addition, this paper proposes a novel evaluation metric, 1D Fréchet Inception Distance (1DFID), to assess the quality of the generated ECG signals. Simulation experiments show that HQ-DCGAN exhibits strong performance in ECG signal generation. Furthermore, the generated signals achieve an average classification accuracy of 82.2%, outperforming the baseline algorithms. It has been experimentally proven that HQ-DCGAN is friendly to currently noisy intermediate-scale quantum (NISQ) computers, in terms of both number of qubits and circuit depths, while improving the stability.
The class imbalance of electrocardiogram (ECG) data is a serious impediment to the development of diagnostic systems for heart disease. To address this issue, this paper proposes HQ-DCGAN, a hybrid quantum deep convolutional generative adversarial network, specifically designed for the generation of ECGs. The proposed algorithm employs different quantum convolutional layers for the generator and discriminator as feature extractors and utilizes parameterized quantum circuits (PQCs) to enhance computational capabilities, along with the model-feature mapping process. Moreover, this algorithm preserves the nonlinearity and scalability inherent to classical convolutional neural networks (CNNs), thereby optimizing the utilization of quantum resources, and ensuring compatibility with contemporary quantum devices. In addition, this paper proposes a novel evaluation metric, 1D Fréchet Inception Distance (1DFID), to assess the quality of the generated ECG signals. Simulation experiments show that HQ-DCGAN exhibits strong performance in ECG signal generation. Furthermore, the generated signals achieve an average classification accuracy of 82.2%, outperforming the baseline algorithms. It has been experimentally proven that HQ-DCGAN is friendly to currently noisy intermediate-scale quantum (NISQ) computers, in terms of both number of qubits and circuit depths, while improving the stability.
Although cardiovascular disease constitutes the primary cause of death in China, the clinical deployment of artificial intelligence-assisted diagnostic tools remains constrained by the limited availability of large-scale, high-fidelity electrocardiogram datasets with adequate privacy safeguards. Conventional generative adversarial networks (GANs) encounter persistent constraints regarding temporal sequence representation, elevated-dimensional attribute extraction, and optimization stability, concurrently failing to accommodate resource limitations inherent to contemporary noisy intermediate-scale quantum (NISQ) apparatus. Drawing inspiration from ensemble methodologies typified by random forests, this investigation introduces an ECG generative information architecture designated QRFGAN-ECG, predicated upon quantum random forest generative adversarial networks. The generative component implements quantum residual recurrent networks (QResRNN) to encapsulate extended-range cardiac cycle dependencies; conversely, the discriminative module incorporates quantum random forest convolutional networks (QRF-CNN) to execute multi-resolution attribute voting, thereby augmenting discrimination robustness. Variational quantum circuit architectures formulated through matrix product states (MPS) and tree tensor networks (TTN) substantially diminish qubit requirements and circuit depth. Furthermore, this study pioneerly integrates quantum dropout mechanisms with forest ensemble strategies to mitigate quantum overfitting phenomena. Empirical evaluations conducted across four publicly accessible ECG repositories demonstrate QRFGAN-ECG superiority over classical Against BiGRU-CNN, ECG-QGAN, and DCGAN baselines, the proposed framework demonstrates superior performance across Pearson correlation coefficient, percentage root-mean-square difference, root-mean-square error, and downstream classification accuracy. Adversarial training convergence improves by roughly one-third, with markedly enhanced robustness to four dominant quantum noise regimes. The generated ECG samples carry intrinsic labels, eliminating manual annotation overhead while precluding privacy exposure. These synthetic specimens readily support training set expansion, establishing a dependable data foundation for cardiac disease diagnostic assistance systems.
The development of effective deep learning systems for cardiac disease diagnosis requires extensive and diverse electrocardiogram (ECG) databases, which remain scarce due to patient confidentiality regulations and costly medical annotation procedures. This paper introduces a novel hybrid Quantum Generative Adversarial Network (QGAN) that generates realistic 12-lead ECG signals trained on the MIT-BIH Arrhythmia Database. A parameterised quantum circuit (PQC) serves as the generative core, exploiting quantum superposition and entanglement to model biomedical signal distributions that traditional generators cannot efficiently replicate. The system pairs a PennyLane-based quantum generator with a 1D Convolutional Neural Network discriminator implemented in PyTorch, trained via the parameter-shift rule. Experimental results demonstrate that the Quantum PQC achieves a Fréchet Distance of 12.3 ±2.1, outperforming Classical CNN (15.8 ±3.2) and Classical LSTM (18.4 ±4.1) baselines while using fewer parameters. Generated 12-lead traces accurately reproduce P-waves, QRS complexes, T-waves, and inter-lead spatial relationships, validating quantum-augmented synthesis as a viable, privacy-preserving approach for cardiovascular AI training.
To address the scarcity and class imbalance of abnormal electrocardiogram (ECG) databases, which are crucial in AI-driven diagnostic tools for potential cardiovascular disease detection, this study proposes a novel quantum conditional generative adversarial algorithm (QCGAN-ECG) for generating abnormal ECG signals. The QCGAN-ECG constructs a quantum generator based on patch method. In this method, each sub-generator generates distinct features of abnormal heartbeats in different segments. This patch-based generative algorithm conserves quantum resources and makes QCGAN-ECG practical for near-term quantum devices. Additionally, QCGAN-ECG introduces quantum registers as control conditions. It encodes information about the types and probability distributions of abnormal heartbeats into quantum registers, rendering the entire generative process controllable. Simulation experiments on Pennylane demonstrated that the QCGAN-ECG could generate completely abnormal heartbeats with an average accuracy of 88.8%. Moreover, the QCGAN-ECG can accurately fit the probability distribution of various abnormal ECG data. In the anti-noise experiments, the QCGAN-ECG showcased outstanding robustness across various levels of quantum noise interference. These results demonstrate the effectiveness and potential applicability of the QCGAN-ECG for generating abnormal ECG signals, which will further promote the development of AI-driven cardiac disease diagnosis systems. The source code is available at github.com/VanSWK/QCGAN_ECG.
Cardiovascular disease has become a major public health issue as the leading cause of death. Timely and accurate detection of heart disease is critical to prevent additional harm to patients. Recent studies show that the implementation of datadriven approaches in medicine, including machine learning (ML) and deep learning (DL), significantly improves the speed and accuracy of heart disease diagnosis. This study proposes a hybrid deep learning model that integrates traditional convolutional neural networks (CNNs) with quantum computing to improve the accuracy of the prediction of cardiovascular diseases. The model uses a parameterized quantum circuit (PQC) to encode patient data, including ECG signals and cardiac images, into quantum states to extract quantum features. Quantum gates modify quantum states to extract complex and high-dimensional features that may be beyond the capabilities of conventional algorithms. A CNN uses convolutional filters to detect localized patterns, including arrhythmias and structural heart abnormalities, to diagnose cardiovascular disease. The CNN then receives the output from the PQC. Integrating quantum feature extraction with conventional deep learning improves prediction accuracy and robustness, facilitating the analysis of high-dimensional and spatially dependent data. The ability of the hybrid model to identify cardiovascular diseases in their early stages may enable faster and more accurate diagnostic results, making it an innovative tool for personalized medicine.
Hybrid Quantum Generative Adversarial Networks (HQ-GANs) have emerged as a promising class of models at the intersection of quantum computing and generative artificial intelligence. Unlike early quantum generative approaches that relied on fully quantum pipelines, hybrid QGANs combine parameterized quantum circuits with classical optimization and discrimination mechanisms, enabling practical training under the constraints of noisy intermediate-scale quantum (NISQ) hardware. This paper presents a comprehensive technical review of hybrid QGAN architectures, with a particular focus on implicit quantum representations and hybrid optimization strategies that enhance expressivity, stability, and scalability. We analyze how recent advances in variational circuit design, data re-encoding, Wasserstein-based objectives, and hybriddepth control have reshaped the feasibility of quantum generative learning. New mathematical formulations are introduced to describe implicit quantum mappings and hybrid adversarial convergence. Comparative analysis highlights performance trends, architectural trade-offs, and unresolved challenges related to noise, barren plateaus, and hardware–software mismatch. The paper concludes by outlining future research directions toward robust, application-ready quantum generative intelligence.
Abstract Quantum Neural Networks (QNNs) present a promising research direction in image recognition, demonstrating significant potential for various applications. However, QNNs with a fixed circuit topology structure are prone to encountering the barren plateaus during training when processing exponential number of qubits, which limit their performance and scalability. In this paper, a novel Hybrid Quantum-Classical Inception-inspired Convolutional Neural Networks (HQCNN) is proposed. The HQCNN enhances feature learning capability and mitigates the barren plateau issue by integrating quantum convolutional kernels with diverse circuit topologies across multiple channels. The architecture employs an amplitude encoding layer to map multi-channel classical data into quantum states, followed by diverse quantum convolutional kernels that extract feature representations. Furthermore, Hadamard gates are used to intergrate multi-channel features and incorporate quantum pooling to reduce feature dimensionality, with a fully connected layer mapping the quantum-enhancing features into class labels for classification tasks. Finally, by analyzing the influence of the circuit structures and quantum gate combinations on the models' performance, the optimal HQCNN architecture is constructed. Experimental results demonstrate that HQCNN achieves 98.5% accuracy on the MNIST-4 classification task and 92.5% accuracy on the MNIST-10 classification task, which indicates that the proposed model outperforms state-of-the-art HQCNN models and classical CNN in image classification with about 10% parameters. This study provides an effective approach for alleviating the barren plateau issue and designing multi-channel quantum convolutional neural networks for processing big classic data with fewer quantum resources.