Using quantum computing, this paper addresses two scientifically-pressing and day to day-relevant problems, namely, chemical retrosynthesis which is an important step in drug/material discovery and security of semiconductor supply chain. We show that Quantum Long Short-Term Memory (QLSTM) is a viable tool for retrosynthesis. We achieve 65% training accuracy with QLSTM whereas classical LSTM can achieve 100%. However, in testing we achieve 80% accuracy with the QLSTM while classical LSTM peaks at only 70% accuracy! We also demonstrate an application of Quantum Neural Network (QNN) in the hardware security domain, specifically in Hardware Trojan (HT) detection using a set of power and area Trojan features. The QNN model achieves detection accuracy as high as 97.27%.
Using quantum computing, this paper addresses two scientifically-pressing and day to day-relevant problems, namely, chemical retrosynthesis which is an important step in drug/material discovery and security of semiconductor supply chain. We show that Quantum Long Short-Term Memory (QLSTM) is a viable tool for retrosynthesis. We achieve 65% training accuracy with QLSTM whereas classical LSTM can achieve 100%. However, in testing we achieve 80% accuracy with the QLSTM while classical LSTM peaks at only 70% accuracy! We also demonstrate an application of Quantum Neural Network (QNN) in the hardware security domain, specifically in Hardware Trojan (HT) detection using a set of power and area Trojan features. The QNN model achieves detection accuracy as high as 97.27%.
Using quantum computing, this paper addresses two scientifically pressing and day-to-day relevant problems, namely, chemical retrosynthesis which is an important step in drug/material discovery and security of the semiconductor supply chain. We show that Quantum Long Short-Term Memory (QLSTM) is a viable tool for retrosynthesis. We achieve 65% training accuracy with QLSTM, whereas classical LSTM can achieve 100%. However, in testing, we achieve 80% accuracy with the QLSTM while classical LSTM peaks at only 70% accuracy! We also demonstrate an application of Quantum Neural Network (QNN) in the hardware security domain, specifically in Hardware Trojan (HT) detection using a set of power and area Trojan features. The QNN model achieves detection accuracy as high as 97.27%.
Quantum computing combined with machine learning (ML) is a highly promising research area, with numerous studies demonstrating that quantum machine learning (QML) is expected to solve scientific problems more effectively than classical ML. In this work, we present Quantum Long Short-Term Memory (QLSTM), a QML architecture, and demonstrate its effectiveness in drug discovery. We evaluate QLSTM on five benchmark datasets (BBBP, BACE, SIDER, BCAP37, T-47D), and observe consistent performance gains over classical LSTM, with ROC-AUC improvements ranging from 3% to over 6%. Furthermore, QLSTM exhibits improved predictive accuracy as the number of qubits increases, and faster convergence than classical LSTM under the same training conditions. Notably, QLSTM maintains strong robustness against quantum computer noise, outperforming noise-free classical LSTM in certain settings. These findings highlight the potential of QLSTM as a scalable and noise-resilient model for scientific applications, particularly as quantum hardware continues to advance in qubit capacity and fidelity.
Abstract Quantum computing combined with machine learning (ML) is a highly promising research area, with numerous studies demonstrating that quantum machine learning (QML) is expected to solve scientific problems more effectively than classical ML. In this work, we present Quantum Long Short-Term Memory (QLSTM), a QML architecture, and demonstrate its effectiveness in drug discovery. We evaluate QLSTM on five benchmark datasets (BBBP, BACE, SIDER, BCAP37, T-47D), and observe consistent performance gains over classical LSTM, with ROC-AUC improvements ranging from 3% to over 6%. Furthermore, QLSTM exhibits improved predictive accuracy as the number of qubits increases, and faster convergence than classical LSTM under the same training conditions. Notably, QLSTM maintains strong robustness against quantum computer noise, outperforming noise-free classical LSTM in certain settings. These findings highlight the potential of QLSTM as a scalable and noise-resilient model for scientific applications, particularly as quantum hardware continues to advance in qubit capacity and fidelity.
Quantum machine learning (QML) offers new perspectives for modeling complex sequential data by leveraging the computational advantages of quantum computing. In this work, we explore the application of Quantum Long Short-Term Memory (QLSTM) networks for sequence prediction tasks. By integrating parameterized quantum circuits within the classical LSTM architecture, QLSTM models exploit quantum parallelism and entanglement to learn temporal dependencies in data more efficiently. We evaluate the performance of QLSTM on synthetic and real-world sequence prediction tasks and compare it with its classical counterpart. The results demonstrate that QLSTM models achieve competitive performance with fewer trainable parameters, indicating their potential as lightweight and efficient models for sequence learning and prediction.
The field of financial security faces a hard challenge when it comes to detecting credit card fraud because accurate efficient models are required to separate fraudulent transactions from legitimate ones. Most fraud detection systems today utilize deep learning methods supported by Graph Convolutional Networks and Graph Neural Networks. Companies experience several difficulties when implementing these detection methods because they demonstrate poor scale-up potential and high implementation expenses and insufficient accuracy in complex fraud detection tasks. The research presents the Quantum Long Short-Term Memory (QLSTM) model that demonstrates potential for credit card fraud detection purposes. Despite its quantum nature QLSTM optimizes learning functions by advancing representation of data features while speeding up training time. Our model receives evaluation against GNN along with GCN framework using numerous benchmark datasets for fraud detection. Experimental findings indicate that QLSTM delivers superior performance than GNN and GCN at every stage of various measurement benchmarks. The training process of QLSTM achieves near-perfect 99% accuracy after 100 epochs making it outperform GNN and GCN significantly according to our accuracy comparison graph.
Merger of Quantum computing and Machine learning explores a new shift in artificial intelligence. Quantum neural networks and parameterized quantum circuits are tools that enable the merger of these two branches. Here, we use Quantum circuit enabled long short term memory (QLSTM) neural network to forecast time series data. We show the efficacy of quantum computing by conducting experiments on two different time series data sets. In our first experiment, we are predicting the amount of rainfall fall and the second experiment has electric load (power) prediction. Our dataset for rainfall prediction includes hourly information on the weather conditions i.e., wind speed, wind direction, minimum and maximum temperatures, and pressure with the amount of rain falls. For electric load (power generation) dataset, few of the features include amount of biomass, amount of fossil brown coal/ignite, amount of fossil coal derived gas, nuclear power, solar power, and the corresponding wind velocity forecasts. We compare the training as well as the test loss of classical Bidirectional LSTM (BILSTM) and the Quantum BILSTM and observe that LSTM based on quantum approach reduces both the training and test loss considerably when compared to its classical part with very few epochs of training.