Many microscopic properties of the only natural superfluid element helium have become available within the last 18 years through a number of novel experiments. The diffraction of matter-waves of small helium clusters has established the unusually large bond distance (5.2 nm) and extremely weak binding energy (10−7 eV) of the dimer and other exotic properties of small helium clusters. The high-resolution spectroscopy of closed-shell chromophore molecules attached to small clusters or embedded inside large superfluid droplets have revealed that as a result of superfluidity, molecules rotate virtually without friction and that only a handful of He atoms are required for microscopic superfluidity. The frictionless translational motion of atoms and molecules inside the droplets has also been observed. These and a number of other experiments demonstrate that helium droplets are the most gentle and coldest of all cryomatrices with enormous potential for a wide range of future applications.