An ultracold gas of interacting fermionic atoms in a three-dimensional optical lattice is considered, where the lattice potential strength is periodically modulated. This non-equilibrium system is non-perturbatively described by means of a Keldysh-Floquet-Green's function approach for Mott-Hubbard systems employing a generalized dynamical mean field theory (DMFT). Strong repulsive interactions between different atoms lead to a Mott insulator state for the equilibrium system, but the additional external driving at zero temperature yields a non-equilibrium quantum critical behavior, where an infinite number of Floquet states arise and a transition to the liquid and conducting phase is given.