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Lawrence Berkeley National Laboratory

Detection of bacteria in suspension using a superconducting QUantum in terference device

Helene L. Grossman, Whittier Myers, V. J. Vreeland, J. Alper, Carolyn Ruth Bertozzi, J. C larke

Published Jun 9, 2003• 0 citations

Abstract

Classification: Biological Sciences: Biophysics Detection of Bacteria in Suspension Using a Superconducting Quantum Interference Device H. L. Grossman *† , W. R. Myers *† , V. J. Vreeland † , R. Bruehl †‡ , M. D. Alper †§ , C. R. Bertozzi †‡§¶ , and John Clarke *† Departments of * Physics, ‡ Chemistry, and § Molecular and Cell Biology, and ¶ Howard Hughes Medical Institute, University of California, Berkeley, CA 94720; † Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720. Corresponding author: John Clarke Address: Department of Physics, 366 LeConte Hall #7300, University of California, Berkeley, CA 94720-7300 Telephone: 510-642-3069 Fax: 510-642-1304 Email: jclarke@socrates.berkeley.edu Number of text pages and figures: 31 Number of words in abstract: 213 Total number of characters in paper: 46,395 Abbreviations: SQUID, superconducting quantum interference device; T c , critical temperature

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Classification: Biological Sciences: Biophysics Detection of Bacteria in Suspension Using a Superconducting Quantum Interference Device H. L. Grossman *† , W. R. Myers *† , V. J. Vreeland † , R. Bruehl †‡ , M. D. Alper †§ , C. R. Bertozzi †‡§¶ , and John Clarke *† Departments of * Physics, ‡ Chemistry, and § Molecular and Cell Biology, and ¶ Howard Hughes Medical Institute, University of California, Berkeley, CA 94720; † Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720. Corresponding author: John Clarke Address: Department of Physics, 366 LeConte Hall #7300, University of California, Berkeley, CA 94720-7300 Telephone: 510-642-3069 Fax: 510-642-1304 Email: jclarke@socrates.berkeley.edu Number of text pages and figures: 31 Number of words in abstract: 213 Total number of characters in paper: 46,395 Abbreviations: SQUID, superconducting quantum interference device; T c , critical temperature

It is well known that the electrodynamic properties of SQUIDs (Superconducting Quantum Interference Devices) are obtained by means of the dynamics of the Josephson junctions in these superconducting system (Barone & Paterno, 1982; Likharev, 1986; Clarke & Braginsky, 2004). Due to the intrinsic macroscopic coherence of superconductors, r. f. SQUIDs have been proposed as basic units (qubits) in quantum computing (Bocko et al., 1997). In the realm of quantum computing non-dissipative quantum systems with small (or null) inductance parameter and finite capacitance of the Josephson junctions (JJs) are usually considered (Crankshaw & Orlando, 2001). The mesoscopic non-simply connected classical devices, on the other hand, are generally operated and studied in the overdamped limit with negligible capacitance of the JJs and small (or null) values of the inductance parameter. Nonetheless, r. f. SQUIDs find application in a large variety of fields, from biomedicine to aircraft maintenance (Clarke & Braginsky, 2004), justifying actual scientific interest in them.

The Royal Swedish Academy of Sciences awarded the 2025 Nobel Prize in Physics jointly to John Clarke, Michel H. Devoret, and John M. Martinis for their foundational discovery of macroscopic quantum mechanical tunneling and energy quantization in electrical circuits. The work that was honored was conducted primarily in the mid-1980s in John Clarke’s laboratory at the University of California—Berkeley, as described in two articles in Physical Review Letters [M. H. Devoret, J. M. Martinis, J. Clarke, Phys. Rev. Lett. 55 , 1908–1911 (1985); J. M. Martinis, M. H. Devoret, J. Clarke, Phys. Rev. Lett. 55 , 1543–1546 (1985)]. This work effectively bridged the gap between the microscopic world of atoms and the macroscopic world of human-scale engineering.

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