Matter-wave diffraction can put chiral molecules into superpositions of left-and right-handed forms, enabling new studies of how the two states interact with their environment.
Molecular matter-wave interferometry enables novel strategies for manipulating the internal mechanical motion of complex molecules.Here, we show how chiral molecules can be prepared in a quantum superposition of two enantiomers by far-field matter-wave diffraction and how the resulting tunneling dynamics can be observed.We determine the impact of rovibrational phase averaging and propose a setup for sensing enantiomer-dependent forces, parity-violating weak interactions, and environment-induced superselection of handedness, as suggested to resolve Hund's paradox.Using ab initio tunneling calculations, we identify [4]-helicene derivatives as promising candidates to implement the proposal with state-of-the-art techniques.This work opens the door for quantum sensing with chiral molecules.