Abstract This book aims to reconceptualize the quantum measurement problem as a problem of epistemology, and to explore the epistemic problems faced by a number of popular interpretations of quantum mechanics. It argues that a number of well-known solutions to the measurement problem, including the many-worlds interpretation and the observer-relative interpretations, face potentially fatal epistemic problems. It also delves into the relationship between physics and epistemology, using the measurement problem to motivate an account of scneitifc epistemology which highlights the role of coherence in justifying the use we make of measurements and observations in the scientific process.