We address basic questions concerning the atomistic-level description of “chemical” materials and their “changes” in the framework of current quantum mechanical understanding of natural phenomena. In this framework, we show how modern quantum chemical analysis of chemical reaction mechanisms, based on Fukui’s intrinsic reaction coordinate (IRC) and the Pauling-like bond order descriptors of natural resonance theory (NRT), can serve to resolve the logical paradoxes of Schrödinger’s cat and Wigner’s “impossibility of life” proof in common-sense manner.