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Non-Hermitian boundary violations of fundamental theorems of Quantum Mechanics and their physical significance

Konstantinos Moulopoulos

Published Jul 30, 2018• 0 citations
OpenAlex

Abstract

For real potentials and for arbitrary boundary conditions we point to previously noted paradoxes in applications of the Ehrenfest and Hellmann-Feynman theorems, their resolution and their role on the consistency of quantum mechanical uncertainty relations. The paradoxes originate from a hidden non-Hermitian character of the kinetic energy operator and are resolved if the proper boundary terms (almost always discarded in the literature) are taken seriously. These non-Hermitian contributions (reflections at a deeper level of topological anomalies) follow their own patterns (for any dimensionality, for both Schroedinger and Dirac/Weyl Hamiltonians and for either continuous or lattice (tight-binding) models): they can always be written as global fluxes of certain generalized current densities. In continuous nonrelativistic cases, these have the forms that had earlier been used by Chemists to describe atomic fragments of polyatomic molecules - while for Dirac/Weyl or lattice models they appear to have the corresponding relativistic forms. In spite of the fact that these boundary terms originate from a deep mathematical anomaly, we point out examples where such non-Hermiticities have physical significance in Quantum Condensed Matter Physics (for both conventional and topologically nontrivial materials). In all stationary state examples considered, these non-Hermitian boundary terms have turned out to be quantized, this quantization being either of conventional or of a topological (Quantum Hall Effect (QHE)-type) origin. The latter claim is substantiated through direct application to a simple QHE arrangement (2-D Landau system in an external electric field). Finally, the non-Hermitian terms are also shown to be crucial for the consistency of the standard uncertainty relations (of Kennard/Robertson-type) in multiply-connected space or, generally, in any system that satisfies a Bloch theorem.

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Non-Hermitian boundary contributions to fundamental relations and theorems of Quantum Mechanics and their physical significance

Konstantinos Moulopoulos

For real potentials and for arbitrary boundary conditions we point to previously noted paradoxes in applications of the Ehrenfest and Hellmann-Feynman theorems, their resolution and the role played on the consistency of quantum mechanical uncertainty relations. The paradoxes originate from a hidden non-Hermitian character of the kinetic energy operator and are resolved if the proper boundary terms (almost always discarded in the literature) are taken seriously. These non-Hermitian contributions (reflections at a deeper level of topological anomalies) follow their own patterns (for any dimensionality, for both Schroedinger and Dirac/Weyl Hamiltonians and for either continuous or lattice (tight-binding) models): they can always be written as global fluxes of certain generalized current densities. In continuous nonrelativistic cases, these have the forms that had earlier been used by Chemists to describe atomic parts of polyatomic molecules while for Dirac/Weyl or lattice models they appear to have the corresponding relativistic forms. In spite of the fact that these boundary terms originate from a deep mathematical anomaly, we point out examples where such non-Hermiticities have physical significance in Quantum Condensed Matter Physics (for both conventional and topologically nontrivial materials). In all stationary state examples considered, these non-Hermitian boundary terms have turned out to be quantized, this quantization being either of conventional or of a topological (Quantum Hall Effect (QHE)-type) origin. The latter claim is substantiated through direct application to a simple QHE arrangement (2-D Landau system in an external electric field). Finally, the non-Hermitian terms are also shown to be crucial for the consistency of the standard uncertainty relations (of Kennard/Robertson type) in multiply-connected space or, generally, in any system that satisfies the Bloch theorem.

•Jul 30, 2018•0 citations

Non-Hermiticities even in quantum systems that are closed

Konstantinos Moulopoulos

Rarely noted paradoxes in applications of fundamental quantum relations are pointed out, with their resolution leading to emergent non-Hermitian behaviors due to boundary terms – even for closed systems and with real potentials. The role played by these non-Hermiticities on the consistency of quantum mechanical uncertainty relations is discussed, especially in multiply-connected spaces (more generally, for any system that satisfies the Bloch theorem of Solid State Physics). These subtleties – reflections of topological quantum anomalies – follow their own patterns (for any dimensionality, for both Schrödinger and Dirac/Weyl Hamiltonians and for either continuous or lattice (tight-binding) models): they can always be written as global fluxes of certain generalized current densities Jg. In continuous nonrelativistic models, these have the forms that had earlier been used by Chemists to describe atomic fragments of polyatomic molecules, while for Dirac/Weyl or other lattice models they have more interesting relativistic forms only recently worked out in graphene models. In spite of the deep mathematical origin as quantum anomalies examples are provided here, where such non-Hermiticities have a direct physical significance (for both conventional and topological materials). In all stationary state examples considered, these non-Hermitian boundary terms turn out to be quantized, this quantization being either of conventional or of a topological (Quantum Hall Effect (QHE)-type) origin. The latter claim is substantiated through direct application to a simple QHE arrangement (2D Landau system in an external in-plane electric field), where some particular Jg seems to be related to the well-known dissipationless edge currents. More generally, the non-Hermitian terms play a subtle role on Berry curvatures in solids and seem to be crucial for the consistent application of the so called Modern Theories of Polarization and Orbital Magnetization. It is emphasized that the above systems can be _closed_ (in multiply-connected space, so that the boundaries disappear, but the non-Hermiticity remains), a case in non-Hermitian physics that is not usually discussed in the literature; it is also stressed that a mapping between the above non-Hermiticity (for continuous systems) and the many recent available results in tight-binding solid state models (leading to the so-called exceptional points) is expected to promote enhanced understanding of quantum behavior at the most fundamental level.

arXiv:1807.11593•Jul 30, 2018•1 citation

6th International Workshop on Pseudo-Hermitian Hamiltonians in Quantum Physics

Andreas Fring, Hugh F Jones, Miloslav Znojil

Attempts to understand the quantum mechanics of non-Hermitian Hamiltonian systems can be traced back to the early days, one example being Heisenberg's endeavour to formulate a consistent model involving an indefinite metric. Over the years non-Hermitian Hamiltonians whose spectra were believed to be real have appeared from time to time in the literature, for instance in the study of strong interactions at high energies via Regge models, in condensed matter physics in the context of the XXZ-spin chain, in interacting boson models in nuclear physics, in integrable quantum field theories as Toda field theories with complex coupling constants, and also very recently in a field theoretical scenario in the quantization procedure of strings on an AdS 5 x S 5 background. Concrete experimental realizations of these types of systems in the form of optical lattices have been proposed in 2007. In the area of mathematical physics similar non-systematic results appeared sporadically over the years. However, intensive and more systematic investigation of these types of non- Hermitian Hamiltonians with real eigenvalue spectra only began about ten years ago, when the surprising discovery was made that a large class of one-particle systems perturbed by a simple non-Hermitian potential term possesses a real energy spectrum. Since then regular international workshops devoted to this theme have taken place. This special issue is centred around the 6th International Workshop on Pseudo-Hermitian Hamiltonians in Quantum Physics held in July 2007 at City University London. All the contributions contain significant new results or alternatively provide a survey of the state of the art of the subject or a critical assessment of the present understanding of the topic and a discussion of open problems. Original contributions from non-participants were also invited. Meanwhile many interesting results have been obtained and consensus has been reached on various central conceptual issues in the growing community of this subject. It is, for instance, well understood that the reality of the spectrum can be attributed either to the unbroken PT-symmetry of the entire system, that is, invariance of the Hamiltonian and the corresponding wavefunctions under a simultaneous parity transformation and time reversal, or more generally to its pseudo-Hermiticity . When the spectrum is real and discrete the Hamiltonian is actually quasi-Hermitian, with a positive-definite metric operator, and can in principle be related by a similarity transformation to an isospectral Hermitian counterpart. For all approaches well-defined procedures have been developed, which allow one to construct metric operators and therefore a consistent description of the underlying quantum mechanical observables. Even though the general principles have been laid out, it remains a challenge in most concrete cases to implement the entire procedure. Solvable models in this sense, some of which may be found in this issue, remain a rare exception. Nonetheless, despite this progress some important questions are still unanswered. For instance, according to the current understanding the non-Hermitian Hamiltonian does not uniquely define the physics of the system since a meaningful metric can no longer be associated with the system in a non-trivial and unambiguous manner. A fully consistent scattering theory has also not yet been formulated. Other issues remain controversial, such as the quantum brachistochrone problem, the problem of forming a mixture between a Hermitian and non-Hermitian system, the new phenomenological possibilities of forming a kind of worm-hole effect, etc. We would like to acknowledge the financial support of the London Mathematical Society, the Institute of Physics, the Doppler Institute in Prague and the School of Engineering and Mathematical Science of City University London. We hope this special issue will be useful to the newcomer as well as to the expert in the subject. Participants of the 6th International Workshop on Pseudo-Hermitian Hamiltonians in Quantum Physics.

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Non-Hermitian physics

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A review is given on the foundations and applications of non-Hermitian classical and quantum physics. First, key theorems and central concepts in non-Hermitian linear algebra, including Jordan normal form, biorthogonality, exceptional points, pseudo-Hermiticity, and parity-time symmetry, are delineated in a pedagogical and mathematically coherent manner. Building on these, we provide an overview of how diverse classical systems, ranging from photonics, mechanics, electrical circuits, and acoustics to active matter, can be used to simulate non-Hermitian wave physics. In particular, we discuss rich and unique phenomena found therein, such as unidirectional invisibility, enhanced sensitivity, topological energy transfer, coherent perfect absorption, single-mode lasing, and robust biological transport. We then explain in detail how non-Hermitian operators emerge as an effective description of open quantum systems on the basis of the Feshbach projection approach and the quantum trajectory approach. We discuss their applications to physical systems relevant to a variety of fields, including atomic, molecular and optical physics, mesoscopic physics, and nuclear physics with emphasis on prominent phenomena and subjects in quantum regimes, such as quantum resonances, superradiance, the continuous quantum Zeno effect, quantum critical phenomena, Dirac spectra in quantum chromodynamics, and nonunitary conformal field theories. Finally, we introduce the notion of band topology in complex spectra of non-Hermitian systems and present their classifications by providing the proof, first given by this review in a complete manner, as well as a number of instructive examples. Other topics related to non-Hermitian physics, including nonreciprocal transport, speed limits, nonunitary quantum walk, are also reviewed.

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ALI MOSTAFAZADEH

A diagonalizable non-Hermitian Hamiltonian having a real spectrum may be used to define a unitary quantum system, if one modifies the inner product of the Hilbert space properly. We give a comprehensive and essentially self-contained review of the basic ideas and techniques responsible for the recent developments in this subject. We provide a critical assessment of the role of the geometry of the Hilbert space in conventional quantum mechanics to reveal the basic physical principle motivating our study. We then offer a survey of the necessary mathematical tools, present their utility in establishing a lucid and precise formulation of a unitary quantum theory based on a non-Hermitian Hamiltonian, and elaborate on a number of relevant issues of fundamental importance. In particular, we discuss the role of the antilinear symmetries such as [Formula: see text], the true meaning and significance of the so-called charge operators [Formula: see text] and the [Formula: see text]-inner products, the nature of the physical observables, the equivalent description of such models using ordinary Hermitian quantum mechanics, the pertaining duality between local-non-Hermitian versus nonlocal-Hermitian descriptions of their dynamics, the corresponding classical systems, the pseudo-Hermitian canonical quantization scheme, various methods of calculating the (pseudo-) metric operators, subtleties of dealing with time-dependent quasi-Hermitian Hamiltonians and the path-integral formulation of the theory, and the structure of the state space and its ramifications for the quantum Brachistochrone problem. We also explore some concrete physical applications and manifestations of the abstract concepts and tools that have been developed in the course of this investigation. These include applications in nuclear physics, condensed matter physics, relativistic quantum mechanics and quantum field theory, quantum cosmology, electromagnetic wave propagation, open quantum systems, magnetohydrodynamics, quantum chaos and biophysics.

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Alí Mostafazadeh

A diagonalizable non-Hermitian Hamiltonian having a real spectrum may be used to define a unitary quantum system, if one modifies the inner product of the Hilbert space properly. We give a comprehensive and essentially self-contained review of the basic ideas and techniques responsible for the recent developments in this subject. We provide a critical assessment of the role of the geometry of the Hilbert space in conventional quantum mechanics to reveal the basic physical principle motivating our study. We then offer a survey of the necessary mathematical tools and elaborate on a number of relevant issues of fundamental importance. In particular, we discuss the role of the antilinear symmetries such as PT, the true meaning and significance of the charge operators C and the CPT-inner products, the nature of the physical observables, the equivalent description of such models using ordinary Hermitian quantum mechanics, the pertaining duality between local-non-Hermitian versus nonlocal-Hermitian descriptions of their dynamics, the corresponding classical systems, the pseudo-Hermitian canonical quantization scheme, various methods of calculating the (pseudo-) metric operators, subtleties of dealing with time-dependent quasi-Hermitian Hamiltonians and the path-integral formulation of the theory, and the structure of the state space and its ramifications for the quantum Brachistochrone problem. We also explore some concrete physical applications of the abstract concepts and tools that have been developed in the course of this investigation. These include applications in nuclear physics, condensed matter physics, relativistic quantum mechanics and quantum field theory, quantum cosmology, electromagnetic wave propagation, open quantum systems, magnetohydrodynamics, quantum chaos, and biophysics.

•Oct 31, 2008•36 citations
For real potentials and for arbitrary boundary conditions we point to previously noted paradoxes in applications of the Ehrenfest and Hellmann-Feynman theorems, their resolution and their role on the consistency of quantum mechanical uncertainty relations. The paradoxes originate from a hidden non-Hermitian character of the kinetic energy operator and are resolved if the proper boundary terms (almost always discarded in the literature) are taken seriously. These non-Hermitian contributions (reflections at a deeper level of topological anomalies) follow their own patterns (for any dimensionality, for both Schroedinger and Dirac/Weyl Hamiltonians and for either continuous or lattice (tight-binding) models): they can always be written as global fluxes of certain generalized current densities. In continuous nonrelativistic cases, these have the forms that had earlier been used by Chemists to describe atomic fragments of polyatomic molecules - while for Dirac/Weyl or lattice models they appear to have the corresponding relativistic forms. In spite of the fact that these boundary terms originate from a deep mathematical anomaly, we point out examples where such non-Hermiticities have physical significance in Quantum Condensed Matter Physics (for both conventional and topologically nontrivial materials). In all stationary state examples considered, these non-Hermitian boundary terms have turned out to be quantized, this quantization being either of conventional or of a topological (Quantum Hall Effect (QHE)-type) origin. The latter claim is substantiated through direct application to a simple QHE arrangement (2-D Landau system in an external electric field). Finally, the non-Hermitian terms are also shown to be crucial for the consistency of the standard uncertainty relations (of Kennard/Robertson-type) in multiply-connected space or, generally, in any system that satisfies a Bloch theorem.
For real potentials and for arbitrary boundary conditions we point to previously noted paradoxes in applications of the Ehrenfest and Hellmann-Feynman theorems, their resolution and the role played on the consistency of quantum mechanical uncertainty relations. The paradoxes originate from a hidden non-Hermitian character of the kinetic energy operator and are resolved if the proper boundary terms (almost always discarded in the literature) are taken seriously. These non-Hermitian contributions (reflections at a deeper level of topological anomalies) follow their own patterns (for any dimensionality, for both Schroedinger and Dirac/Weyl Hamiltonians and for either continuous or lattice (tight-binding) models): they can always be written as global fluxes of certain generalized current densities. In continuous nonrelativistic cases, these have the forms that had earlier been used by Chemists to describe atomic parts of polyatomic molecules while for Dirac/Weyl or lattice models they appear to have the corresponding relativistic forms. In spite of the fact that these boundary terms originate from a deep mathematical anomaly, we point out examples where such non-Hermiticities have physical significance in Quantum Condensed Matter Physics (for both conventional and topologically nontrivial materials). In all stationary state examples considered, these non-Hermitian boundary terms have turned out to be quantized, this quantization being either of conventional or of a topological (Quantum Hall Effect (QHE)-type) origin. The latter claim is substantiated through direct application to a simple QHE arrangement (2-D Landau system in an external electric field). Finally, the non-Hermitian terms are also shown to be crucial for the consistency of the standard uncertainty relations (of Kennard/Robertson type) in multiply-connected space or, generally, in any system that satisfies the Bloch theorem.
Rarely noted paradoxes in applications of fundamental quantum relations are pointed out, with their resolution leading to emergent non-Hermitian behaviors due to boundary terms – even for closed systems and with real potentials. The role played by these non-Hermiticities on the consistency of quantum mechanical uncertainty relations is discussed, especially in multiply-connected spaces (more generally, for any system that satisfies the Bloch theorem of Solid State Physics). These subtleties – reflections of topological quantum anomalies – follow their own patterns (for any dimensionality, for both Schrödinger and Dirac/Weyl Hamiltonians and for either continuous or lattice (tight-binding) models): they can always be written as global fluxes of certain generalized current densities Jg. In continuous nonrelativistic models, these have the forms that had earlier been used by Chemists to describe atomic fragments of polyatomic molecules, while for Dirac/Weyl or other lattice models they have more interesting relativistic forms only recently worked out in graphene models. In spite of the deep mathematical origin as quantum anomalies examples are provided here, where such non-Hermiticities have a direct physical significance (for both conventional and topological materials). In all stationary state examples considered, these non-Hermitian boundary terms turn out to be quantized, this quantization being either of conventional or of a topological (Quantum Hall Effect (QHE)-type) origin. The latter claim is substantiated through direct application to a simple QHE arrangement (2D Landau system in an external in-plane electric field), where some particular Jg seems to be related to the well-known dissipationless edge currents. More generally, the non-Hermitian terms play a subtle role on Berry curvatures in solids and seem to be crucial for the consistent application of the so called Modern Theories of Polarization and Orbital Magnetization. It is emphasized that the above systems can be _closed_ (in multiply-connected space, so that the boundaries disappear, but the non-Hermiticity remains), a case in non-Hermitian physics that is not usually discussed in the literature; it is also stressed that a mapping between the above non-Hermiticity (for continuous systems) and the many recent available results in tight-binding solid state models (leading to the so-called exceptional points) is expected to promote enhanced understanding of quantum behavior at the most fundamental level.
Attempts to understand the quantum mechanics of non-Hermitian Hamiltonian systems can be traced back to the early days, one example being Heisenberg's endeavour to formulate a consistent model involving an indefinite metric. Over the years non-Hermitian Hamiltonians whose spectra were believed to be real have appeared from time to time in the literature, for instance in the study of strong interactions at high energies via Regge models, in condensed matter physics in the context of the XXZ-spin chain, in interacting boson models in nuclear physics, in integrable quantum field theories as Toda field theories with complex coupling constants, and also very recently in a field theoretical scenario in the quantization procedure of strings on an AdS 5 x S 5 background. Concrete experimental realizations of these types of systems in the form of optical lattices have been proposed in 2007. In the area of mathematical physics similar non-systematic results appeared sporadically over the years. However, intensive and more systematic investigation of these types of non- Hermitian Hamiltonians with real eigenvalue spectra only began about ten years ago, when the surprising discovery was made that a large class of one-particle systems perturbed by a simple non-Hermitian potential term possesses a real energy spectrum. Since then regular international workshops devoted to this theme have taken place. This special issue is centred around the 6th International Workshop on Pseudo-Hermitian Hamiltonians in Quantum Physics held in July 2007 at City University London. All the contributions contain significant new results or alternatively provide a survey of the state of the art of the subject or a critical assessment of the present understanding of the topic and a discussion of open problems. Original contributions from non-participants were also invited. Meanwhile many interesting results have been obtained and consensus has been reached on various central conceptual issues in the growing community of this subject. It is, for instance, well understood that the reality of the spectrum can be attributed either to the unbroken PT-symmetry of the entire system, that is, invariance of the Hamiltonian and the corresponding wavefunctions under a simultaneous parity transformation and time reversal, or more generally to its pseudo-Hermiticity . When the spectrum is real and discrete the Hamiltonian is actually quasi-Hermitian, with a positive-definite metric operator, and can in principle be related by a similarity transformation to an isospectral Hermitian counterpart. For all approaches well-defined procedures have been developed, which allow one to construct metric operators and therefore a consistent description of the underlying quantum mechanical observables. Even though the general principles have been laid out, it remains a challenge in most concrete cases to implement the entire procedure. Solvable models in this sense, some of which may be found in this issue, remain a rare exception. Nonetheless, despite this progress some important questions are still unanswered. For instance, according to the current understanding the non-Hermitian Hamiltonian does not uniquely define the physics of the system since a meaningful metric can no longer be associated with the system in a non-trivial and unambiguous manner. A fully consistent scattering theory has also not yet been formulated. Other issues remain controversial, such as the quantum brachistochrone problem, the problem of forming a mixture between a Hermitian and non-Hermitian system, the new phenomenological possibilities of forming a kind of worm-hole effect, etc. We would like to acknowledge the financial support of the London Mathematical Society, the Institute of Physics, the Doppler Institute in Prague and the School of Engineering and Mathematical Science of City University London. We hope this special issue will be useful to the newcomer as well as to the expert in the subject. Participants of the 6th International Workshop on Pseudo-Hermitian Hamiltonians in Quantum Physics.
A review is given on the foundations and applications of non-Hermitian classical and quantum physics. First, key theorems and central concepts in non-Hermitian linear algebra, including Jordan normal form, biorthogonality, exceptional points, pseudo-Hermiticity, and parity-time symmetry, are delineated in a pedagogical and mathematically coherent manner. Building on these, we provide an overview of how diverse classical systems, ranging from photonics, mechanics, electrical circuits, and acoustics to active matter, can be used to simulate non-Hermitian wave physics. In particular, we discuss rich and unique phenomena found therein, such as unidirectional invisibility, enhanced sensitivity, topological energy transfer, coherent perfect absorption, single-mode lasing, and robust biological transport. We then explain in detail how non-Hermitian operators emerge as an effective description of open quantum systems on the basis of the Feshbach projection approach and the quantum trajectory approach. We discuss their applications to physical systems relevant to a variety of fields, including atomic, molecular and optical physics, mesoscopic physics, and nuclear physics with emphasis on prominent phenomena and subjects in quantum regimes, such as quantum resonances, superradiance, the continuous quantum Zeno effect, quantum critical phenomena, Dirac spectra in quantum chromodynamics, and nonunitary conformal field theories. Finally, we introduce the notion of band topology in complex spectra of non-Hermitian systems and present their classifications by providing the proof, first given by this review in a complete manner, as well as a number of instructive examples. Other topics related to non-Hermitian physics, including nonreciprocal transport, speed limits, nonunitary quantum walk, are also reviewed.
A diagonalizable non-Hermitian Hamiltonian having a real spectrum may be used to define a unitary quantum system, if one modifies the inner product of the Hilbert space properly. We give a comprehensive and essentially self-contained review of the basic ideas and techniques responsible for the recent developments in this subject. We provide a critical assessment of the role of the geometry of the Hilbert space in conventional quantum mechanics to reveal the basic physical principle motivating our study. We then offer a survey of the necessary mathematical tools, present their utility in establishing a lucid and precise formulation of a unitary quantum theory based on a non-Hermitian Hamiltonian, and elaborate on a number of relevant issues of fundamental importance. In particular, we discuss the role of the antilinear symmetries such as [Formula: see text], the true meaning and significance of the so-called charge operators [Formula: see text] and the [Formula: see text]-inner products, the nature of the physical observables, the equivalent description of such models using ordinary Hermitian quantum mechanics, the pertaining duality between local-non-Hermitian versus nonlocal-Hermitian descriptions of their dynamics, the corresponding classical systems, the pseudo-Hermitian canonical quantization scheme, various methods of calculating the (pseudo-) metric operators, subtleties of dealing with time-dependent quasi-Hermitian Hamiltonians and the path-integral formulation of the theory, and the structure of the state space and its ramifications for the quantum Brachistochrone problem. We also explore some concrete physical applications and manifestations of the abstract concepts and tools that have been developed in the course of this investigation. These include applications in nuclear physics, condensed matter physics, relativistic quantum mechanics and quantum field theory, quantum cosmology, electromagnetic wave propagation, open quantum systems, magnetohydrodynamics, quantum chaos and biophysics.
A diagonalizable non-Hermitian Hamiltonian having a real spectrum may be used to define a unitary quantum system, if one modifies the inner product of the Hilbert space properly. We give a comprehensive and essentially self-contained review of the basic ideas and techniques responsible for the recent developments in this subject. We provide a critical assessment of the role of the geometry of the Hilbert space in conventional quantum mechanics to reveal the basic physical principle motivating our study. We then offer a survey of the necessary mathematical tools and elaborate on a number of relevant issues of fundamental importance. In particular, we discuss the role of the antilinear symmetries such as PT, the true meaning and significance of the charge operators C and the CPT-inner products, the nature of the physical observables, the equivalent description of such models using ordinary Hermitian quantum mechanics, the pertaining duality between local-non-Hermitian versus nonlocal-Hermitian descriptions of their dynamics, the corresponding classical systems, the pseudo-Hermitian canonical quantization scheme, various methods of calculating the (pseudo-) metric operators, subtleties of dealing with time-dependent quasi-Hermitian Hamiltonians and the path-integral formulation of the theory, and the structure of the state space and its ramifications for the quantum Brachistochrone problem. We also explore some concrete physical applications of the abstract concepts and tools that have been developed in the course of this investigation. These include applications in nuclear physics, condensed matter physics, relativistic quantum mechanics and quantum field theory, quantum cosmology, electromagnetic wave propagation, open quantum systems, magnetohydrodynamics, quantum chaos, and biophysics.