A Comparative Analysis of Classical and Quantum Approaches for Heart Attack Prediction
Rohan Landge, Shreni Bandgar, Rohit Salke +3 more
Heart diseases are a set of heart and blood-vessel-related disorders, arising from a variety of lifestyle, environmental, and genetic factors. Even with advancements in medical technology, accurately forecasting heart attack risk remains challenging, as today’s diagnosis methods fail to catch the nonlinearity and complexity in clinical data. Classical machine learning algorithms, such as k-nearest neighbors and support vector machine, when mixed with synthetic minority oversampling technique, show promise for heart attack risk prediction. These models for real-world scenarios struggle with high-dimensional, imbalanced, nonlinear datasets, which limits the effectiveness of models. Quantum machine learning offers a computational approach and takes benefit of concepts like superposition and entanglement to uncover insightful patterns. In this work, we compare classical and quantum models for heart attack risk prediction using a heart attack prediction dataset with 14 clinical features and 1888 patient records. The outcomes demonstrate that the classical support vector machine, when combined with synthetic minority oversampling technique, achieves the highest predictive accuracy of 92.00%, with minimal run time. k-nearest neighbors also works well, with an accuracy of 83.33%. Among quantum methods, quantum support vector machine with quantum Fourier transform achieves a 74.00% accuracy, while quantum clustering reaches 67.20%. However, both approaches required higher computational power. The quantum Fourier transform–based approach improves quantum model performance, particularly in recognizing cyclic trends in clinical data. However, classical approaches remain superior with respect to accuracy and efficiency on current hardware. This work demonstrates the strength of quantum machine learning in handling complex data while also recognizing the present challenges with quantum hardware and simulators. It suggests that upcoming research should focus on testing these models on actual quantum devices. Adopting standardized performance metrics can improve both classical and quantum-based decision support systems for heart disease risk prediction.
Auerbach Publications eBooks•Feb 24, 2026•0 citations