We investigate the strength of Fano interference effects on the probe absorption spectra in asymmetric semiconductor quantum wells driven coherently by a probe laser field. We find that the probe absorption can be dramatically reduced due to the strength of the Fano interference, and the effect of the energy splitting on the probe absorption is also discussed. Our study is much more practical than its atomic counterpart due to its flexible design and the controllable interference strength. Thus it may provide some possibilities for technological applications in optoelectronics and solid-state quantum information science.