Using operators of the invariance group of their time-dependent Schr\"odinger equations it is shown that the bound states of Morse oscillators are bases for discrete nonunitary irreducible representations (non-UIRs) of the groups
Sp(2,R), SU(1,1), and SO(2,1). Hermiticity requirements and the dependence of the group generators on the dynamical variables determine the operator of an isometry which connects these non-UIRs of the noncompact invariance groups to UIRs of the compact groups SU(2) and SO(3) that have been used as spectrum-generating groups for Morse systems.