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Biosystems

Molecular solutions to the binary integer programming problem based on DNA computation

Chung-Wei Yeh, Chih‐Ping Chu, Kee-Rong Wu

Published Oct 18, 2005• 36 citations
Publisher
DOI
10.1016/j.biosystems.2005.09.005

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Quantum computing is emerging as a new computing resource that could be superior to conventional computing for certain classes of optimization problems. However, in principle, most existing approaches to quantum optimization are intended to solve unconstrained binary programming problems, while mixed-integer linear programming is of most interest in practice. We attempt to bridge the gap between the capability of quantum computing and real-world applications by developing a new approach for mixed-integer programming. The approach applies Benders decomposition to decompose the mixed-integer programming into binary programming and linear programming sub-problems, which are solved by a noisy intermediate-scale quantum processor and conventional processor, respectively. The algorithm is provably able to reach the optimal solution of the original mixed-integer programming problem. The algorithm is tested on a D-Wave 2000Q quantum processing unit and is shown to be effective for small-scaled test cases. We also test the algorithm on a mixed-integer programming inspired by power system applications. Many insights are drawn from the numerical results for both the capabilities and limitations of the proposed algorithm.