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Il Nuovo Cimento D

Isotopic dimension in biology—A counterpart for quantum indeterminism?

Alexander A. Berezin

Published Jun 1, 1987• 2 citations
Publisher
DOI
10.1007/bf02457033

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• Published in PNAS, the study demonstrates a quantum effect through a "differential isotope effect" on the formation of amorphous calcium phosphate. • Posner molecules, pinpointed as "neural qutrits" in the brain's neural network, show different aggregation rates and particle abundances depending on the lithium isotope. • Elucidating the cause of biological lithium isotope effects provides new clues for the therapeutic mechanisms of neuropsychiatric diseases and the quantum biological interpretation of brain cognitive functions. [Quantum Biology Society] Groundbreaking experimental results have emerged to support the theory that quantum mechanics may be involved in brain neural networks and cognitive functions. Through the Proceedings of the National Academy of Sciences (PNAS), a research team published evidence that a quantum effect operates in the formation of lithium-doped amorphous calcium phosphate (ACP). This study focused on symmetric calcium phosphate molecular species known as "Posner molecules." Posner molecules are substances that have been theorized to process quantum information by acting as "neural qutrits"—three-state quantum systems—within the body. ■ Biological Quantum Effects Discovered via Isotopes To identify nonclassical quantum effects in complex biological systems, the researchers utilized "differential isotope effects" as an emerging tool. In vitro experimental results confirmed that, under identical solution preparations, lithium-7 promoted a greater abundance of observable calcium phosphate particles compared to lithium-6. This suggests that the self-binding rates of Posner molecules depend on the nuclear spin of phosphorus, and this quantum dynamics is differentially modulated by doping with lithium isotopes. ■ The Convergence of Brain Science and Quantum Biology This achievement provides a potential explanation for in vivo biological lithium isotope effects, whose exact mechanisms have previously remained unclear. Calcium phosphate plays a crucial role in biological systems, ranging from mitochondrial signaling pathways to key biomineralization processes. Beyond understanding the principles of calcium phosphate nucleation, these research findings are expected to become an important milestone in elucidating lithium's role in living systems—including its therapeutic mechanism for psychiatric conditions like mania—and the potential role of calcium phosphate in quantum processing in the brain.