A Majorana zero bound mode exists in the vortex core of a chiral
p+ip superconductor or superfluid, which can be driven from an
s-wave pairing state by two-dimensional spin-orbit coupling. We propose here a novel scheme based on realistic cold atom platforms to generate two-dimensional spin-orbit interactions in a blue-detuned square optical lattice, and predict both the quantum anomalous Hall effect and chiral topological superfluid phase in the experimentally accessible parameter regimes. This work may open a new direction with experimental feasibility to observe non-Abelian topological orders in cold atom systems.