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InTech eBooks

Fundamentals and Applications of Quantum Limited Optical Imaging

Warwick P. Bowen, Magnus T. L. Hsu, Jian Wei

Published Apr 1, 2010• 0 citations
Publisher

Abstract

Advances in Lasers and Electro Optics 634 how the QNL to measurement sensitivity may be determined and even surpassed using non-classical states of light.We illustrate the implications of these techniques for two key imaging systems, atomic force microscopy (Binning et al., 1985;Fabre et al., 2000) and particle tracking in optical tweezers (Block, 1992;Tay et al., 2009); comparing optimal spatial homodyne based signal extraction to the standard extraction methods used in such systems today.

DOI
10.5772/8674

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Advances in Lasers and Electro Optics 634 how the QNL to measurement sensitivity may be determined and even surpassed using non-classical states of light.We illustrate the implications of these techniques for two key imaging systems, atomic force microscopy (Binning et al., 1985;Fabre et al., 2000) and particle tracking in optical tweezers (Block, 1992;Tay et al., 2009); comparing optimal spatial homodyne based signal extraction to the standard extraction methods used in such systems today.
This thesis reports the development of a quantum enhanced microparticle tracking technique, which applied to measurements within living cells, allowed the first demonstrations of both biological measurements beyond the quantum noise limit and quantum enhanced spatial resolution within biology. The sensitivity of any optical measurement is limited by noise which follows from quantization of the electromagnetic field. This thesis theoretically characterizes the resulting quantum limit on particle tracking precision; both in the limit of perfect measurements and for the measurements used in real experiments, and theoretically establishes an experimental strategy which could allow the quantum limit to be surpassed via the application of non-classical light. Further, a computational tool is developed which allows rapid characterization of particle tracking experiments, thus providing researchers the benefit of rigorous theoretical predictions without requiring detailed calculations. Following this, classical technologies are developed which can improve microparticle tracking sensitivity and which are enabling steps toward integration of non-classical light. An interferometric strategy is described whereby signal-to-noise is improved by removing unwanted light from the detector. An optical lock-in technique is developed which eliminates low-frequency noise, thus allowing quantum noise limited performance at low frequencies. This is a crucial requirement for quantum enhanced measurements, and can also improve precision in classical experiments. Dark-field illumination is also explored as a method to remove unwanted background light, and the optimal illumination angle is calculated for our intended experiments. These advances are then applied in the development of the first quantum enhanced particle tracking apparatus. Squeezed states of light are used to improve particle tracking precision by 2.7 dB, demonstrating quantum enhanced microscopy for the first time. This was applied to perform the first measurements of living systems with quantum enhanced precision. Naturally occurring lipid particles were tracked within the cytoplasm of Saccharomyces cerevisiae yeast cells, with squeezed light enhancing precision by 2.4 dB. The thermal motion of these particles could then be analyzed to infer the viscosity and elasticity of the local environment, with squeezed light allowing 64% faster observations, thus improving the sensitivity to dynamic biological changes. This experiment was then extended to spatially resolved quantum imaging, with lipid particles used as scanning probes in a technique called photonic force microscopy. The particles sample variations in the local environment with resolution limited by measurement precision rather than the diffraction limit. The use of squeezed light was found to enhance spatial resolution by 14% at an absolute resolution level of 10 nm, comparable to leading classical experiments. This was the first demonstration of both sub-diffraction limited resolution and quantum enhanced resolution in biology, and places practical applications of quantum imaging within reach. Finally, the future challenges and prospects of quantum enhanced particle tracking are outlined.n
Tracking small transverse displacements of an optical beam with ultra-high accuracy is a fundamental problem underlying numerous important applications ranging from pointing, acquisition and tracking for establishing a lasercom link, to atomic force microscopy for imaging with atomic-scale resolution. Determining what is the optimal quantum-optical probe and the best achievable sensitivity of measuring a small transverse optical beam displacement, is the fundamental question central to these sensing schemes. By mapping this problem to an array of nested Mach-Zehnder interferometers, we explicitly construct the optimal probe state. It is entangled across the spatial modes allowed within the Fresnel number product of the propagation geometry, and entangled across the temporal modes within the time-bandwidth product of the optical probe. We show that the optimal sensitivity of measuring the beam displacement achieves a Heisenberg limited scaling over both the number of temporal modes and the average number of photons transmitted per mode. Surprisingly, we discover a sub-Heisenberg limited scaling over the number of available spatial modes. To qualify the quantum enhancement, we also establish the optimal sensitivity of a classical-light probe, which gives shot-noise limit over both the number of temporal modes and the number of photons per mode, and Heisenberg limited scaling over the number of spatial modes. Finally, we construct an explicit design for quantum-enhanced beam tracking, which uses a Gaussian (multi-mode-entangled squeezed-state) probe and a Gaussian (multi-mode homodyne) receiver.
The ultimate sensitivity of any optically based measurement using classical resources (for example, laser or thermal light) is constrained by the photon shot noise limit (SNL). However, quantum states of light, in which photon pairs have quantum correlations or entanglement, off er a path beyond this limit. In particular, “squeezing” in these quantum states makes it possible to lower the noise in the detection system below the SNL. This can signifi cantly enhance the sensitivity of real-world devices and could thus revolutionize optical-based sensing applications
The displacement of micro-electro-mechanical-systems (MEMS) cantilevers is used to measure a broad variety of phenomena in devices ranging from force microscopes to biochemical sensors to thermal imaging systems. We demonstrate the first direct measurement of a MEMS cantilever displacement with a noise floor at 40% of the shot noise limit (SNL). By combining multi-spatial-mode quantum light sources with a simple differential measurement, we show that sub-SNL MEMS displacement sensitivity is highly accessible compared to previous efforts that measured the displacement of macroscopic mirrors with very distinct spatial structures crafted with multiple optical parametric amplifiers and locking loops. These results support a new class of quantum MEMS sensor with an ultimate signal to noise ratio determined by quantum correlations, enabling ultra-trace sensing, imaging, and microscopy applications in which signals were previously obscured by shot noise.