Uncertainty relations represent a foundational principle in quantum mechanics, imposing inherent limits on the precision with which \textit{mechanically} conjugate variables such as position and momentum can be simultaneously determined. This work establishes analogous relations for \textit{thermodynamically} conjugate variables -- specifically, a classical intensive parameter
θ and its corresponding extensive quantum operator
O^ -- in equilibrium states. We develop a framework to derive a rigorous thermodynamic uncertainty relation for such pairs, where the uncertainty of the classical parameter
θ is quantified by its quantum Fisher information
Fθ. The framework is based on an exact integral representation that relates
Fθ to the autocorrelation function of operator
O^. From this representation, we derive a tight upper bound for the quantum Fisher information, which yields a thermodynamic uncertainty relation:
ΔθΔO≥kBT with
ΔO≡∂θ⟨O^⟩Δθ and
T is the system temperature. The result establishes a fundamental precision limit for quantum sensing and metrology in thermal systems, directly connecting it to the thermodynamic properties of linear response and fluctuations.