Hybrid quantum-classical computing has emerged as the dominant paradigm for near-term quantum applications, yet hybrid workflows are typically described by individual algorithms rather than their underlying execution behavior. We introduce the Quantum Execution Locality Framework (QELF), a qualitative framework for characterizing hybrid quantum-classical workflows according to recurring dataflow structures and quantum execution locality, the extent to which computation remains resident on the Quantum Processing Unit (QPU) before host intervention or classical synchronization. From a representative cross-section of applications, QELF identifies five recurring computational patterns with distinct locality characteristics and discusses their implications for communication overhead, workflow organization, and future hybrid computing architectures. By providing a common vocabulary for reasoning about hybrid workloads, QELF establishes a foundation for future quantitative validation and the co-design of algorithms, runtime systems, and hybrid computing architectures.
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4 pages. Accepted to the IEEE Quantum Week 2026 Workshop on Advancing Hybrid Computing Through Shared Challenges (WKS115)
Hybrid quantum-classical computing has emerged as the dominant paradigm for near-term quantum applications, yet hybrid workflows are typically described by individual algorithms rather than their underlying execution behavior. We introduce the Quantum Execution Locality Framework (QELF), a qualitative framework for characterizing hybrid quantum-classical workflows according to recurring dataflow structures and quantum execution locality, the extent to which computation remains resident on the Quantum Processing Unit (QPU) before host intervention or classical synchronization. From a representative cross-section of applications, QELF identifies five recurring computational patterns with distinct locality characteristics and discusses their implications for communication overhead, workflow organization, and future hybrid computing architectures. By providing a common vocabulary for reasoning about hybrid workloads, QELF establishes a foundation for future quantitative validation and the co-design of algorithms, runtime systems, and hybrid computing architectures.
Recent computations involving quantum processing units (QPUs) have demonstrated a series of challenges inherent to hybrid classical-quantum programming, compilation, execution, and verification and validation. Despite considerable progress, system-level noise, limited low-level instructions sets, remote access models, and an overall lack of portability and classical integration presents near-term programming challenges that must be overcome in order to enable reliable scientific quantum computing and support robust hardware benchmarking. In this work, we draw on our experience in programming QPUs to identify common concerns and challenges, and detail best practices for mitigating these challenges within the current hybrid classical-quantum computing paradigm. Following this discussion, we introduce the XACC quantum compilation and execution framework as a hardware and language independent solution that addresses many of these hybrid programming challenges. XACC supports extensible methodologies for managing a variety of programming, compilation, and execution concerns across the increasingly diverse set of QPUs. We use recent nuclear physics simulations to illustrate how the framework mitigates programming, compilation, and execution challenges and manages the complex workflow present in QPU-enhanced scientific applications. Finally, we codify the resulting hybrid scientific computing workflow in order to identify key areas requiring future improvement.
Hybrid quantum-classical workflows are expected to underpin practical quantum computing applications, yet the quantum and HPC communities lack a shared framework for reasoning about where and when their integration requirements matter most. Such a framework must separate two distinct levels of analysis: the application level, where communication overhead affects runtime performance, and the real-time level, where it determines feasibility. To address this, we introduce a runtime model that decomposes workflow execution into quantum compute, classical compute, and communication costs. At the application level, a communication-to-computation ratio from this decomposition quantifies whether a workflow is communication-bound or compute-bound; at the real-time level, a feasibility constraint determines whether timing requirements can be met at all, with the reaction time setting the logical clock speed of fault-tolerant computation once they are. Application of this model to representative workflows demonstrates that co-location of quantum processors with HPC infrastructure offers negligible performance benefit for compute-intensive applications today, while tight integration remains crucial for real-time tasks such as quantum error correction needed for large scale quantum computations. However, we discuss how even at the application level these assessments may shift with hardware evolution, illustrating how the model can identify specific crossover conditions, and how, under fault tolerance, the reaction time can set application-level performance.
Although quantum hardware has made significant progress, constraints such as limited qubit counts and noise still hinder its practical impact on scientific and industrial challenges. Integrating multiple quantum processing units (QPUs) with HPC resources (e.g., GPUs and CPUs) is a promising approach. However, quantum–HPC integration introduces new complexities, including resource orchestration, workload partitioning, and quantum-classical coordination. This paper identifies emerging quantum workflow execution patterns, illustrating the interaction between quantum and classical components in hybrid quantum workflow applications. We classify these execution patterns into six basic motifs centered on simple quantum-classical interactions (e.g., circuit execution) and introduce two compositional motifs as orchestration of one or more basic motifs. The variational quantum algorithm (VQA) compositional motif captures new parallelism strategies by concurrently running classical solvers and quantum circuit evaluations. The generative quantum algorithm (GQA) compositional motif describes how GPU-accelerated AI models can generate or refine quantum circuits, which are then executed on QPUs. Characterizing these basic and compositional motifs provides a structured path toward scalable quantum–HPC middleware solutions, informing design at the task, workload orchestration, and application levels.
High-performance computing (HPC) has evolved over decades through multiple architectural transitions, from vector supercomputers to massively parallel CPU clusters and GPU-accelerated systems, continuously expanding the frontier of scientific discovery. With the emergence of quantum processing units (QPUs) as practical computational accelerators, a new opportunity arises to further extend this trajectory by integrating quantum and classical computing paradigms. Building on the emerging vision of Quantum Integrated High-Performance Computing (QHPC), this paper contributes a full-stack layered architecture that integrates QPUs as first-class accelerators within, not merely alongside, the classical HPC software and hardware stack, with tight, on-premise quantum-classical coupling as its defining characteristic. The architecture comprises of unified resource management, quantum-aware scheduling, hybrid workflow orchestration, middleware and programming abstraction, interconnect technologies, and a tiered execution model enabling seamless workload partitioning across classical and quantum backends. A central aspect of this architecture is a strong user requests abstraction layer that exposes heterogeneous resources through a unified job submission interface, similar in spirit to existing schedulers such as Slurm, allowing users to describe workloads in a consistent template independent of underlying compute type or location. Drawing insights from prior accelerator integration eras, we outline how QHPC can support emerging workloads in quantum chemistry, materials discovery, combinatorial optimization, and climate modeling. We conclude by highlighting open challenges in building scalable, reliable, and programmable quantum-classical infrastructures that seamlessly connect global users to heterogeneous compute resources for future quantum-classical HPC ecosystems.
High-performance computing (HPC) has evolved over decades through multiple architectural transitions, from vector supercomputers to massively parallel CPU clusters and GPU-accelerated systems, continuously expanding the frontier of scientific discovery. With the emergence of quantum processing units (QPUs) as practical computational accelerators, a new opportunity arises to further extend this trajectory by integrating quantum and classical computing paradigms. Building on the emerging vision of Quantum Integrated High-Performance Computing (QHPC), this paper contributes a full-stack layered architecture that integrates QPUs as first-class accelerators within, not merely alongside, the classical HPC software and hardware stack, with tight, on-premise quantum–classical coupling as its defining characteristic. The architecture comprises of unified resource management, quantum-aware scheduling, hybrid workflow orchestration, middleware and programming abstraction, interconnect technologies, and a tiered execution model enabling seamless workload partitioning across classical and quantum backends. A central aspect of this architecture is a strong user requests abstraction layer that exposes heterogeneous resources through a unified job submission interface, similar in spirit to existing schedulers such as Slurm, allowing users to describe workloads in a consistent template independent of underlying compute type or location. Drawing insights from prior accelerator integration eras, we outline how QHPC can support emerging workloads in quantum chemistry, materials discovery, combinatorial optimization, and climate modeling. We conclude by highlighting open challenges in building scalable, reliable, and programmable quantum–classical infrastructures that seamlessly connect global users to heterogeneous compute resources for future quantum–classical HPC ecosystems.
Quantum computers have demonstrated utility in simulating quantum systems beyond brute-force classical approaches. As the community builds on these demonstrations to explore using quantum computing for applied research, algorithms and workflows have emerged that require leveraging both quantum computers and classical high-performance computing (HPC) systems to scale applications, especially in chemistry and materials, beyond what either system can simulate alone. Today, these disparate systems operate in isolation, forcing users to manually orchestrate workloads, coordinate job scheduling, and transfer data between systems -- a cumbersome process that hinders productivity and severely limits rapid algorithmic exploration. These challenges motivate the need for flexible and high-performance Quantum-Centric Supercomputing (QCSC) systems that integrate Quantum Processing Units (QPUs), Graphics Processing Units (GPUs), and Central Processing Units (CPUs) to accelerate discovery of such algorithms across applications. These systems will be co-designed across quantum and classical HPC infrastructure, middleware, and application layers to accelerate the adoption of quantum computing for solving critical computational problems. We envision QCSC evolution through three distinct phases: (1) quantum systems as specialized compute offload engines within existing HPC complexes; (2) heterogeneous quantum and classical HPC systems coupled through advanced middleware, enabling seamless execution of hybrid quantum-classical algorithms; and (3) fully co-designed heterogeneous quantum-HPC systems for hybrid computational workflows. This article presents a reference architecture and roadmap for these QCSC systems.