We introduce a hybrid quantum-classical pipeline, based on neutral-atom reservoir computing, for medical image classification, focusing on the binary classification task of polyp detection. To deal effectively with the high dimensionality, we integrate a guided auto-encoder. This pipeline learns compact and discriminative representations of image data that are also well-suited for quantum reservoir computing. A key challenge in such systems is the non-differentiable nature of quantum measurements, which creates a ‘gradient barrier’ for standard training. We overcome this barrier by incorporating a differentiable surrogate model that emulates the quantum layer, enabling end-to-end backpropagation through the entire system. This guided training process is jointly optimized for classification accuracy and for faithful image recovery from the auto-encoder. The learned latent representations are encoded as pulse detuning parameters within a Rydberg Hamiltonian, and quantum embeddings are subsequently obtained through expectation values. These embeddings are then passed to a linear classifier. Our simulations show that this method outperforms some traditional approaches that use PCA or unguided autoencoders. We also conduct ablation studies to assess the impact of various quantum and training parameters, demonstrating the robustness and flexibility of our proposed pipeline for real-world medical imaging applications, even in the current NISQ era.
We introduce a hybrid quantum-classical pipeline, based on neutral-atom reservoir computing, for medical image classification, focusing on the binary classification task of polyp detection. To deal effectively with the high dimensionality, we integrate a guided auto-encoder. This pipeline learns compact and discriminative representations of image data that are also well-suited for quantum reservoir computing. A key challenge in such systems is the non-differentiable nature of quantum measurements, which creates a ‘gradient barrier’ for standard training. We overcome this barrier by incorporating a differentiable surrogate model that emulates the quantum layer, enabling end-to-end backpropagation through the entire system. This guided training process is jointly optimized for classification accuracy and for faithful image recovery from the auto-encoder. The learned latent representations are encoded as pulse detuning parameters within a Rydberg Hamiltonian, and quantum embeddings are subsequently obtained through expectation values. These embeddings are then passed to a linear classifier. Our simulations show that this method outperforms some traditional approaches that use PCA or unguided autoencoders. We also conduct ablation studies to assess the impact of various quantum and training parameters, demonstrating the robustness and flexibility of our proposed pipeline for real-world medical imaging applications, even in the current NISQ era.
In this paper, we define and benchmark a hybrid quantum-classical machine learning pipeline by performing a binary classification task applied to a real-world financial use case. Specifically, we implement a Quantum Reservoir Computing (QRC) layer within a classical routine that includes data preprocessing and binary classification. The reservoir layer has been executed on QuEra's Aquila, a 256-qubit neutral atom simulator, using two different types of encoding: position and local detuning. In the former case, classical data are encoded into the relative distance between atoms; in the latter, into pulse amplitudes. The developed pipeline is applied to predict credit card defaults using a public dataset and a wide variety of traditional classifiers. The results are compared with a fully-classical pipeline including a Deep Neural Network (DNN) model. Additionally, the impact of hardware noise on classification performance is evaluated by comparing the results obtained using Aquila within the classification workflow with those obtained using a classical, noiseless emulation of the quantum system. The results indicate that the noiseless emulation achieves competitive performance with the fully-classical pipeline, while noise significantly degrades overall performance. Although the results for this specific use case are comparable to those of the classical benchmark, the flexibility and scalability of QRC highlight strong potential for a wide range of applications.
Neutral-atom quantum devices offer a natural and powerful platform for Quantum Reservoir Computing (QRC), a non-variational approach to quantum-enhanced machine learning that is attracting growing interest in the Noisy Intermediate-Scale Quantum (NISQ) era. In this work, we implement a QRC-based learning model tailored to Pasqal neutral-atom hardware, where classical data are encoded into time-dependent detuning waveforms and processed through programmable many-body dynamics. Feature embeddings are extracted from single- and two-qubit Pauli-Z observables and used within a simple linear readout model. We systematically investigate both global and local detuning encoding strategies on a supervised image classification task, benchmarking performance against a purely classical linear baseline. Our results show that processing the data through the quantum reservoir yields a consistent $\sim$4\% improvement in accuracy, highlighting the system effectiveness as a nonlinear feature map. Both encoding strategies exhibit comparable performance, suggesting that QRC can leverage different control schemes while remaining compatible with near-term and emerging hardware capabilities. These findings provide concrete evidence that QRC can enhance classical machine learning pipelines by injecting non-classical correlations without the need for variational optimization, thereby avoiding issues such as barren plateaus and training instabilities. More broadly, this work establishes neutral-atom platforms as a promising and scalable setting for QRC, opening the way toward practical quantum-enhanced learning on near-term devices.
Brain tumor image classification is an essential pre-processing task for tumor diagnosis and treatment planning. In medical imaging, quantum computing analyse medical imaging data, offering potential speedups and new representations compared to classical methods. The brain images are transformed through resizing and normalization to a uniform 32 × 32 × 3 resolution. Subsequently, these processed images are converted into vectors to enable encoding into quantum states. The feature set is reduced using Principal Component Analysis (PCA) to ensure compatibility with the restricted qubit count in the quantum circuits. Through amplitude encoding, these vectors are mapped to quantum states, allowing for a compact and efficient data representation within the quantum domain. A parameterized Variational Quantum Circuit(VQC), consisting of entangling gates and trainable rotations, processes the encoded quantum states to learn features that can effectively discriminate between classes. The loss is calculated from the measured expectation values of Pauli-Z observables and optimized using classical gradient descent, where the objective function is the mean squared error. The trained quantum model is designed for multi-class classification, specifically distinguishing between meningioma, glioma tumors, pituitary tumors, and the absence of a tumor. The outcome of this proposed work demonstrates the VQC’s advantage over classical baselines, including Random Forest, and Support Vector Machine (SVM) and Multi-Layer Perceptron (MLP). The VQC achieved the highest accuracy of 95% and the best robustness (Specificity 0.983). Crucially, the VQC accomplished this using only 24 trainable parameters, showcasing a significant increase in parameter efficiency compared to the classical models. The novelty of this work is the quantitative demonstration that a custom-designed, resource-efficient quantum model can outperform established classical deep learning methods in both performance and efficiency for complex medical image classification. The VQC provides a 3.5-fold gain in parameter efficiency, achieving the highest accuracy of 95% using only 24 trainable parameters. This efficiency is enabled by the novel application of amplitude encoding to the medical images, which compresses 16 features into just 4 qubits. The VQC demonstrates robustness vital for medical diagnostics, achieving a Specificity of 0.983. Its shallow architecture is also NISQ-friendly and remains stable by avoiding the Barren Plateau issue (Gradient Norm: 0.11), validating the path toward quantum advantage in diagnostic tools. The results of this approach highlight the potential amplitude encoding in quantum machine learning, as a feasible and effective method for classifying real-world medical images. This work also opens avenues for future hybrid quantum-classical diagnostic systems that could utilize richer quantum state encodings for significant gains in computational efficiency and accuracy.
In this thesis we investigate Quantum Reservoir Computing (QRC) as a non-variational paradigm for quantum machine learning on near-term neutral-atom devices. Motivated by the limitations of NISQ hardware, we implement a QRC pipeline in Pasqal’s Pulser environment that encodes classical inputs into detuning waveforms and extracts embeddings from Pauli-Z and ZZ observables. We design two encoding strategies: a global detuning applied to all atoms and a local detuning. Their performance is benchmarked against a classical PCA baseline using logistic regression. We find that QRC embeddings consistently outperform the classical features, with peak test accuracies of 90.17% (global) and 89.61% (local) compared to ≃ 85% for PCA. The advantage is especially marked in low-data regimes, where quantum dynamics enrich the feature space accessible to linear classifiers. We also identify practical challenges, such as symmetry-induced redundancy in global encoding and the absence of per-qubit detuning in current hardware. This establishes QRC as a promising and experimentally grounded framework to exploit the dynamical richness of neutral-atom platforms for supervised learning in the NISQ era.
Quantum Reservoir Computing (QRC) leverages the natural dynamics of quantum systems for information processing, without requiring a fault-tolerant quantum computer. In this work, we apply QRC within a hybrid quantum classical framework for image denoising. The quantum reservoir is implemented using a Rydberg atom array, while a classical neural network serves as the readout layer. To prepare the input, images are first compressed using Principal Component Analysis (PCA), reducing their dimensionality to match the size of the atom array. Each feature vector is encoded into local detuning parameters of a time-dependent Hamiltonian governing the Rydberg system. As the system evolves, it generates nonlinear embeddings through the measurement of observables across multiple time steps. These temporal embeddings capture complex correlations, which are fed into a classical neural network to reconstruct the denoised images. To evaluate performance, we compare this QRC-assisted model against a baseline architecture consisting of PCA followed by a dense neural network, trained under identical conditions. Our results show that the QRC-based approach achieves improved image sharpness and similar structural recovery compared to the PCA-based model. We demonstrate the practical viability of this framework through experiments on QuEra's Aquila neutral-atom processor, leveraging its programmable atom arrays to physically realize the reservoir dynamics.
Quantum machines enhance the capabilities of classical counterparts across various domains, notably in addressing real-world challenges.The classification of brain MR images for tumor detection is a crucial diagnostic process in the analysis of brain images.Traditional approaches, such as classical machine learning techniques and conventional deep learning structures like convolutional neural networks, are frequently employed for image classification.However, as the network size increases, training these models becomes increasingly arduous.Quantum algorithms offer advantages by optimizing the performance of classical algorithms through the incorporation of the intrinsic properties of quantum bits.In this paper, we proposed a hybrid classical and quantum convolutional neural network for Alzheimer's disease (AD) classification.The proposed model was further validated on the brain tumor classification task.The fundamental concept involves encoding data into quantum states, facilitating quicker information extraction, and subsequently utilizing this information to discern the data class.The proposed model results underscore the reliability and robustness and demonstrated by optimal performance accuracies across various datasets, the proposed model substantiates its efficacy in detecting and classifying AD disease and brain tumors.