Quantum Federated Learning (QFL) enables distributed training of Quantum Machine Learning (QML) models by sharing model gradients instead of raw data. However, these gradients can still expose sensitive user information. To enhance privacy, homomorphic encryption of parameters has been proposed as a solution in QFL and related frameworks. In this work, we evaluate the overhead introduced by Fully Homomorphic Encryption (FHE) in QFL setups and assess its feasibility for real-world applications. We implemented various QML models including a Quantum Convolutional Neural Network (QCNN) trained in a federated environment with parameters encrypted using the CKKS scheme. This work marks the first QCNN trained in a federated setting with CKKS-encrypted parameters. Models of varying architectures were trained to predict brain tumors from MRI scans. The experiments reveal that memory and communication overhead remain substantial, making FHE challenging to deploy. Minimizing overhead requires reducing the number of model parameters, which, however, leads to a decline in classification performance, introducing a trade-off between privacy and model complexity.
Quantum Federated Learning (QFL) enables distributed training of Quantum Machine Learning (QML) models by sharing model gradients instead of raw data. However, these gradients can still expose sensitive user information. To enhance privacy, homomorphic encryption of parameters has been proposed as a solution in QFL and related frameworks. In this work, we evaluate the overhead introduced by Fully Homomorphic Encryption (FHE) in QFL setups and assess its feasibility for real-world applications. We implemented various QML models including a Quantum Convolutional Neural Network (QCNN) trained in a federated environment with parameters encrypted using the CKKS scheme. This work marks the first QCNN trained in a federated setting with CKKS-encrypted parameters. Models of varying architectures were trained to predict brain tumors from MRI scans. The experiments reveal that memory and communication overhead remain substantial, making FHE challenging to deploy. Minimizing overhead requires reducing the number of model parameters, which, however, leads to a decline in classification performance, introducing a trade-off between privacy and model complexity.
The integration of fully homomorphic encryption (FHE) in federated learning (FL) has led to significant advances in data privacy. However, during the aggregation phase, it often results in performance degradation of the aggregated model, hindering the development of robust representational generalization. In this work, we propose a novel multimodal quantum federated learning framework that utilizes quantum computing to counteract the performance drop resulting from FHE. For the first time in FL, our framework combines a multimodal quantum mixture of experts (MQMoE) model with FHE, incorporating multimodal datasets for enriched representation and task-specific learning. Our MQMoE framework enhances performance on multimodal datasets and combined genomics and brain MRI scans, especially for underrepresented categories. Our results also demonstrate that the quantum-enhanced approach mitigates the performance degradation associated with FHE and improves classification accuracy across diverse datasets, validating the potential of quantum interventions in enhancing privacy in FL.
AI-driven medical diagnostics increasingly requires collaborative model training across institutions, yet centralizing patient data conflicts with privacy regulations. Federated Learning enables distributed training without raw data sharing, but remains vulnerable to gradient inversion and model leakage attacks. Furthermore, harvest-now-decrypt-later attacks render computationally secure protocols insufficient for protecting long-lived medical records. Quantum communication offers information-theoretic security immune to such threats, making Quantum Federated Learning (QFL) a compelling framework for healthcare. However, practical deployment is constrained by communication overhead and quantum channel noise. We present a systematic quantitative study of communication, convergence, and noise trade-offs in QFL, introducing two complementary strategies to reduce quantum transmissions: (1) structured parameter reduction via light-cone feature selection in parameterized quantum circuits, and (2) a Hybrid QFL architecture that dynamically switches between centralized and decentralized aggregation. We show that Hybrid QFL reduces total quantum transmissions from 3TNMP, the cost of pure Centralized QFL, to {3t+2(T−t)}NMP over T rounds while preserving near-centralized convergence. We further demonstrate that decentralized aggregation is more noise-resilient under depolarizing noise, and evaluate Steane code-based quantum error correction in high-noise regimes. Our results provide an integrated design framework for communication-efficient, noise-aware QFL, clarifying practical trade-offs for scalable quantum-secure distributed learning in healthcare.
Recent advancements in Quantum Neural Networks (QNNs) have demonstrated theoretical and experimental performance superior to their classical counterparts in a wide range of applications. However, existing centralized QNNs cannot solve many real-world problems because collecting large amounts of training data to a common public site is time-consuming and, more importantly, violates data privacy. Federated Learning (FL) is an emerging distributed machine learning framework that allows collaborative model training on decentralized data residing on multiple devices without breaching data privacy. Some initial attempts at Quantum Federated Learning (QFL) either only focus on improving the QFL performance or rely on a trusted quantum server that fails to preserve data privacy. In this work, we propose CryptoQFL, a QFL framework that allows distributed QNN training on encrypted data. CryptoQFL is (1) secure, because it allows each edge to train a QNN with local private data, and encrypt its updates using quantum homomorphic encryption before sending them to the central quantum server; (2) communication-efficient, as CryptoQFL quantize local gradient updates to ternary values, and only communicate non-zero values to the server for aggregation; and (3) computation-efficient, as CryptoQFL presents an efficient quantum aggregation circuit with significantly reduced latency compared to state-of-the-art approaches.
Quantum machine learning in cloud environments requires protecting sensitive data while enabling remote computation. Here we demonstrate the first realistic implementations of a perfectly-secure quantum homomorphic encryption (QHE) scheme applied to quantum neural networks (QNN). Using efficient Clifford+T decomposition, we implement quantum convolutional neural networks for two complementary scenarios: (i) reverse delegated training, where encrypted data from multiple providers trains a user's network via federated aggregation; (ii) private inference, where users process encrypted data with remote quantum networks. Moreover, analysis of server circuit privacy reveals probabilistic model protection through Pauli gate concealment. These results establish perfectly-secure QHE as a practical framework for multi-party quantum machine learning.
Healthcare organizations have a high volume of sensitive data and traditional technologies have limited storage capacity and computational resources. The prospect of sharing healthcare data for machine learning is more arduous due to government regulations related to patient privacy. In recent years, federated learning has offered a solution to accelerate distributed machine learning addressing concerns related to data privacy and governance. Currently, the blend of quantum computing and machine learning has experienced significant attention from academic institutions and research communities. The ultimate objective of this work is to develop a federated quantum machine learning framework (FQML) to tackle the optimization, security, and privacy challenges in the healthcare industry for medical imaging tasks. In this work, we propose a new methodology based on federated quantum convolutional neural networks (QCNNs) with distributed training across edge devices. To demonstrate the feasibility of the proposed FQML framework, we performed extensive experiments on two benchmark medical datasets (Pneumonia MNIST, and CT kidney disease analysis), which are non-independently and non-identically partitioned among the healthcare institutions/clients. The proposed framework is validated and assessed via large-scale simulations. Based on our results, the quantum simulation experiments achieve performance levels on par with well-known classical CNN models, 86.3% accuracy on the pneumonia dataset and 92.8% on the CT-kidney dataset, while requiring fewer model parameters and consuming less data. Moreover, a client selection mechanism is proposed to reduce the computation overhead at each communication round, which effectively improves the convergence rate.
Abstract Healthcare organizations have a high volume of sensitive data and traditional technologies have limited storage capacity and computational resources. The prospect of sharing healthcare data for machine learning is more arduous due to firm regulations related to patient privacy. The balanced protection of confidentiality, integrity, and availability of healthcare data, has become a major concern beyond classical data security considerations. In recent years, federated learning offers a solution to accelerate distributed machine learning addressing concerns related to data privacy and governance. Currently, the blend of quantum computing and machine learning has experienced significant attention from academic institutions and research communities. Quantum computers have shown the potential to bring huge benefits to the healthcare sector through efficient distributed training across several quantum nodes. The ultimate objective of this work is to develop a quantum federated learning framework (QFL) to tackle the optimization, security, and privacy challenges in the healthcare and clinical industries for medical imaging tasks. In this work, we proposed federated quantum convolutional neural networks (QCNNs) with distributed training across edge devices. To demonstrate the feasibility of the proposed QFL framework, we performed extensive experiments on medical datasets (Pneumonia MNIST, and CT-kidney disease analysis), which are non-independently and non-identically partitioned among the healthcare institutions/clients. The quantum federated global model maintained a high classification testing accuracy and generalizability and outperformed the locally train clients regardless of how unbalanced the medical data is distributed among the clients. The global model achieved the best performance as compared to local clients in terms of the area under curve of the receiver operating characteristic curve (AUCROC) (0.953) and an average of (0.98) on all classes for predicting outcomes on pneumonia and CT-kidney datasets, respectively. Moreover, the client selection mechanism is proposed to reduce the computation overhead at each communication round, which effectively improves the convergence rate. The proposed quantum federated learning framework is validated and assessed via large-scale simulations. Based on our results from numerical simulations, the deployment of distributed and secure quantum machine learning algorithms for enabling scalable and privacy-preserving intelligent healthcare applications would be extremely valuable.