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arXiv:2602.14641

Quantum Reservoir Computing with Neutral Atoms on a Small, Complex, Medical Dataset

Luke Antoncich, Yuben Moodley, Ugo Varetto, Jingbo Wang, Jonathan Wurtz, Jing Chen, Pascal Jahan Elahi, Casey R. Myers

quant-phcs.LGSubmitted Feb 16, 2026• Announced Feb 17, 2026• 0 citations
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Abstract

Biomarker-based prediction of clinical outcomes is challenging due to nonlinear relationships, correlated features, and the limited size of many medical datasets. Classical machine-learning methods can struggle under these conditions, motivating the search for alternatives. In this work, we investigate quantum reservoir computing (QRC), using both noiseless emulation and hardware execution on the neutral-atom Rydberg processor \textit{Aquila}. We evaluate performance with six classical machine-learning models and use SHAP to generate feature subsets. We find that models trained on emulated quantum features achieve mean test accuracies comparable to those trained on classical features, but have higher training accuracies and greater variability over data splits, consistent with overfitting. When comparing hardware execution of QRC to noiseless emulation, the models are more robust over different data splits and often exhibit statistically significant improvements in mean test accuracy. This combination of improved accuracy and increased stability is suggestive of a regularising effect induced by hardware execution. To investigate the origin of this behaviour, we examine the statistical differences between hardware and emulated quantum feature distributions. We find that hardware execution applies a structured, time-dependent transformation characterised by compression toward the mean and a progressive reduction in mutual information relative to emulation.

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Biomarker-based prediction of clinical outcomes is challenging due to nonlinear relationships, correlated features, and the limited size of many medical datasets. Classical machine-learning methods can struggle under these conditions, motivating the search for alternatives. In this work, we investigate quantum reservoir computing (QRC), using both noiseless emulation and hardware execution on the neutral-atom Rydberg processor \textit{Aquila}. We evaluate performance with six classical machine-learning models and use SHAP to generate feature subsets. We find that models trained on emulated quantum features achieve mean test accuracies comparable to those trained on classical features, but have higher training accuracies and greater variability over data splits, consistent with overfitting. When comparing hardware execution of QRC to noiseless emulation, the models are more robust over different data splits and often exhibit statistically significant improvements in mean test accuracy. This combination of improved accuracy and increased stability is suggestive of a regularising effect induced by hardware execution. To investigate the origin of this behaviour, we examine the statistical differences between hardware and emulated quantum feature distributions. We find that hardware execution applies a structured, time-dependent transformation characterised by compression toward the mean and a progressive reduction in mutual information relative to emulation.
In this paper, we define and benchmark a hybrid quantum-classical machine learning pipeline by performing a binary classification task applied to a real-world financial use case. Specifically, we implement a Quantum Reservoir Computing (QRC) layer within a classical routine that includes data preprocessing and binary classification. The reservoir layer has been executed on QuEra's Aquila, a 256-qubit neutral atom simulator, using two different types of encoding: position and local detuning. In the former case, classical data are encoded into the relative distance between atoms; in the latter, into pulse amplitudes. The developed pipeline is applied to predict credit card defaults using a public dataset and a wide variety of traditional classifiers. The results are compared with a fully-classical pipeline including a Deep Neural Network (DNN) model. Additionally, the impact of hardware noise on classification performance is evaluated by comparing the results obtained using Aquila within the classification workflow with those obtained using a classical, noiseless emulation of the quantum system. The results indicate that the noiseless emulation achieves competitive performance with the fully-classical pipeline, while noise significantly degrades overall performance. Although the results for this specific use case are comparable to those of the classical benchmark, the flexibility and scalability of QRC highlight strong potential for a wide range of applications.
Neutral-atom quantum devices offer a natural and powerful platform for Quantum Reservoir Computing (QRC), a non-variational approach to quantum-enhanced machine learning that is attracting growing interest in the Noisy Intermediate-Scale Quantum (NISQ) era. In this work, we implement a QRC-based learning model tailored to Pasqal neutral-atom hardware, where classical data are encoded into time-dependent detuning waveforms and processed through programmable many-body dynamics. Feature embeddings are extracted from single- and two-qubit Pauli-ZZZ observables and used within a simple linear readout model. We systematically investigate both global and local detuning encoding strategies on a supervised image classification task, benchmarking performance against a purely classical linear baseline. Our results show that processing the data through the quantum reservoir yields a consistent $\sim$4\% improvement in accuracy, highlighting the system effectiveness as a nonlinear feature map. Both encoding strategies exhibit comparable performance, suggesting that QRC can leverage different control schemes while remaining compatible with near-term and emerging hardware capabilities. These findings provide concrete evidence that QRC can enhance classical machine learning pipelines by injecting non-classical correlations without the need for variational optimization, thereby avoiding issues such as barren plateaus and training instabilities. More broadly, this work establishes neutral-atom platforms as a promising and scalable setting for QRC, opening the way toward practical quantum-enhanced learning on near-term devices.
Quantum Reservoir Computing (QRC) leverages the natural dynamics of quantum systems for information processing, without requiring a fault-tolerant quantum computer. In this work, we apply QRC within a hybrid quantum classical framework for image denoising. The quantum reservoir is implemented using a Rydberg atom array, while a classical neural network serves as the readout layer. To prepare the input, images are first compressed using Principal Component Analysis (PCA), reducing their dimensionality to match the size of the atom array. Each feature vector is encoded into local detuning parameters of a time-dependent Hamiltonian governing the Rydberg system. As the system evolves, it generates nonlinear embeddings through the measurement of observables across multiple time steps. These temporal embeddings capture complex correlations, which are fed into a classical neural network to reconstruct the denoised images. To evaluate performance, we compare this QRC-assisted model against a baseline architecture consisting of PCA followed by a dense neural network, trained under identical conditions. Our results show that the QRC-based approach achieves improved image sharpness and similar structural recovery compared to the PCA-based model. We demonstrate the practical viability of this framework through experiments on QuEra's Aquila neutral-atom processor, leveraging its programmable atom arrays to physically realize the reservoir dynamics.
In this thesis we investigate Quantum Reservoir Computing (QRC) as a non-variational paradigm for quantum machine learning on near-term neutral-atom devices. Motivated by the limitations of NISQ hardware, we implement a QRC pipeline in Pasqal’s Pulser environment that encodes classical inputs into detuning waveforms and extracts embeddings from Pauli-Z and ZZ observables. We design two encoding strategies: a global detuning applied to all atoms and a local detuning. Their performance is benchmarked against a classical PCA baseline using logistic regression. We find that QRC embeddings consistently outperform the classical features, with peak test accuracies of 90.17% (global) and 89.61% (local) compared to ≃ 85% for PCA. The advantage is especially marked in low-data regimes, where quantum dynamics enrich the feature space accessible to linear classifiers. We also identify practical challenges, such as symmetry-induced redundancy in global encoding and the absence of per-qubit detuning in current hardware. This establishes QRC as a promising and experimentally grounded framework to exploit the dynamical richness of neutral-atom platforms for supervised learning in the NISQ era.
Forecasting neural activity from short recordings remains a fundamental challenge. Reservoir computing may offer an efficient paradigm for temporal prediction, however classical reservoirs typically underperform in small-data regimes. Here we investigate whether quantum reservoir computing (QRC) can help overcome this limitation. Building on recent advances, we introduce a quantum reservoir based on a transverse-field Ising model, combined with heterogeneous quantum measurements and polynomial ridge regression. On a standard benchmark task, results show that the quantum reservoir outperforms a classical counterpart overall, with prediction accuracy strongly dependent on reservoir parameters. We further demonstrate feasibility by running the same task on quantum hardware. To assess performance on biological signals, we evaluate QRC on simulated human electroencephalography (EEG) data with a parallel reservoir architecture. On this challenging task, the tested quantum reservoir did not match the performance of the classical one, but it produced stable, convergent predictions. This is a meaningful first step toward forecasting of biologically realistic neural data using a quantum reservoir. Overall, our findings indicate that although current quantum hardware and parallel reservoir architectures do not yet surpass classical methods on complex neural signals, QRC can be executed on near-term devices and does converge with realistic EEG-like data. This work establishes a practical baseline for future algorithmic and hardware developments aimed at clinical time-series forecasting with quantum systems.
Machine learning has been increasingly utilized in the field of biomedical research to accelerate the drug discovery process. In recent years, the emergence of quantum computing has led to the extensive exploration of quantum machine learning algorithms. Quantum variational machine learning algorithms are currently the most prevalent, but they face issues with trainability due to vanishing gradients. An emerging alternative is the quantum reservoir computing (QRC) approach, in which the quantum algorithm does not require gradient evaluation on the quantum hardware. Motivated by the potential advantages of the QRC method, we apply it to predict the biological activity of potential drug molecules based on molecular descriptors. We observe more robust QRC performance as the size of the data set decreases, compared to standard classical models, a quality of potential interest for pharmaceutical data sets of limited size. In addition, we leverage the uniform manifold approximation and projection technique to analyze structural changes as classical features are transformed through quantum dynamics, and we find that quantum reservoir embeddings provide better separability between active and inactive compounds in the low-dimensional learned feature space.