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arXiv:2511.12386

Leveraging Quantum-Based Architectures for Robust Diagnostics

Shabnam Sodagari, Tommy Long

Published Nov 15, 2025• 0 citations
arXivHTMLPDF

Abstract

Quantum machine learning has emerged as a promising approach for medical image analysis, particularly in settings where compact models and expressive feature representations are desired. This paper presents a hybrid classical--quantum diagnostic framework that integrates dataset-specific preprocessing, transfer learning, and quantum convolutional neural networks (QCNNs) for multi-class medical image classification. This approach is evaluated on three distinct tasks: kidney disease diagnosis from computed tomography images, cervical cell classification from pap smear images, and brain tumor classification from magnetic resonance imaging. For each dataset, a pretrained encoder is used to extract latent features, which are then embedded into quantum states through angle or amplitude encoding and processed by a QCNN. Experimental results show strong and stable convergence across all datasets. The proposed hybrid models achieve 99% test accuracy on kidney CT classification, 97% on cervical cell classification, and 99% on brain tumor classification. In comparative evaluations for precision, recall, and F1, the hybrid QCNN models consistently outperform classical CNN baselines using the same pretrained encoders and similar hyperparameter settings, while requiring fewer trainable parameters. These results demonstrate the potential of quantum-enhanced architectures for robust and efficient medical diagnostics.

DOI
10.48550/arxiv.2511.12386

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Purpose This study investigates the integration of quantum-enhanced machine learning (QML) into medical image analysis, focusing on classification and feature extraction tasks. It aims to evaluate whether hybrid quantum-classical models can overcome the limitations of traditional machine learning in handling high-dimensional, clinically relevant imaging data. Design/methodology/approach Hybrid architectures combining classical preprocessing with quantum components, specifically variational quantum circuits (VQCs) and quantum kernel methods, were developed and implemented in simulated quantum environments using Qiskit and PennyLane on Google Colab. Publicly available datasets (ChestX-ray14, Brain Tumor MRI and CT Hemorrhage) were preprocessed and encoded into quantum states. Model performance was evaluated against classical baselines (MLP and CNN) using accuracy, precision, recall, F1-score, convergence speed and trainable parameters. Findings Quantum-enhanced models achieved competitive or superior performance compared to classical models with significantly fewer trainable parameters and faster convergence. The Quantum Kernel SVM demonstrated the highest precision (89.1%) and F1-score (88.5%) using only 8 parameters, while VQC models converged up to 2× faster than classical baselines. These results highlight the potential of QML to improve efficiency, robustness and scalability in diagnostic imaging workflows, particularly in resource-constrained or data-limited settings. Research limitations/implications The study relies on simulated quantum environments, which do not capture hardware noise or qubit limitations. Future work will extend to real quantum devices, multimodal data integration and interpretability strategies. Practical implications Quantum kernel methods and lightweight VQC architectures enable faster, resource-efficient diagnostic modeling, making them suitable for clinical environments with limited computational capacity or time-sensitive decision-making needs. Social implications Improving the efficiency and accessibility of medical image analysis has the potential to support faster diagnosis and enhance healthcare delivery, particularly in underserved or resource-limited regions. Originality/value This study provides a practical evaluation of hybrid quantum-classical models applied to multiple real medical imaging datasets in a reproducible simulated environment. It offers an early-stage framework demonstrating how QML techniques can be integrated into existing machine learning pipelines for medical image analysis.
Quantum machines enhance the capabilities of classical counterparts across various domains, notably in addressing real-world challenges.The classification of brain MR images for tumor detection is a crucial diagnostic process in the analysis of brain images.Traditional approaches, such as classical machine learning techniques and conventional deep learning structures like convolutional neural networks, are frequently employed for image classification.However, as the network size increases, training these models becomes increasingly arduous.Quantum algorithms offer advantages by optimizing the performance of classical algorithms through the incorporation of the intrinsic properties of quantum bits.In this paper, we proposed a hybrid classical and quantum convolutional neural network for Alzheimer's disease (AD) classification.The proposed model was further validated on the brain tumor classification task.The fundamental concept involves encoding data into quantum states, facilitating quicker information extraction, and subsequently utilizing this information to discern the data class.The proposed model results underscore the reliability and robustness and demonstrated by optimal performance accuracies across various datasets, the proposed model substantiates its efficacy in detecting and classifying AD disease and brain tumors.
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