Challenges
Datasets
Workspaces
Papers
Discussions
Leaderboard
Log inSign up
Challenges
Datasets
Workspaces
Papers
Discussions
Leaderboard
Blog
Job Board
Q3AS

© 2026 Aqora Quantum S.A.S.

TermsPrivacyLegal Notice

arXiv:2507.14116 · IEEE International Conference on Quantum Computing and Engineering (QCE)

Quantum Boltzmann Machines Using Parallel Annealing for Medical Image Classification

Daniëlle Schuman, Mark V. Seebode, Tobias Rohe, Maximilian Balthasar Mansky, Michael Schroedl-Baumann, Jonas Stein, Claudia Linnhoff–Popien, Florian Krellner

Published Aug 30, 2025• 2 citations
arXivHTMLPDF

Abstract

Exploiting the fact that samples drawn from a quantum annealer inherently follow a boltzmann-like distribution, annealing-based Quantum Boltzmann Machines (QBMs) have gained increasing popularity in the quantum research community. While they harbor great promises for quantum speed-up, their usage currently stays a costly endeavor, as large amounts of QPU time are required to train them. This limits their applicability in the NISQ era. Following the idea of Noè et al. [1], who tried to alleviate this cost by incorporating parallel quantum annealing into their unsupervised training of QBMs, this paper presents an improved version of parallel quantum annealing that we employ to train QBMs in a supervised setting. Saving qubits to encode the inputs, the latter setting allows us to test our approach on medical images from the MedMNIST data set [2], thereby moving closer to real-world applicability of the technology. Our experiments show that QBMs using our approach already achieve reasonable results, comparable to those of similarly-sized Convolutional Neural Networks (CNNs), with a markedly smaller numbers of epochs than these classical models. Our using parallel annealing grants it a speed-up of almost 70% compared to regular annealing-based BM execution.

DOI
10.1109/qce65121.2025.00233

Related papers

Towards Transfer Learning for Large-Scale Image Classification Using Annealing-Based Quantum Boltzmann Machines

Daniëlle Schuman, Leo Sünkel, Philipp J. Altmann +4 more

Quantum Transfer Learning (QTL) recently gained popularity as a hybrid quantum-classical approach for image classification tasks by efficiently combining the feature extraction capabilities of large Convolutional Neural Networks with the potential benefits of Quantum Machine Learning (QML). Existing approaches, however, only utilize gate-based Variational Quantum Circuits for the quantum part of these procedures. In this work we present an approach to employ Quantum Annealing (QA) in QTL-based image classification. Specifically, we propose using annealing-based Quantum Boltzmann Machines as part of a hybrid quantum-classical pipeline to learn the classification of real-world, large-scale data such as medical images through supervised training. We demonstrate our approach by applying it to the three-class COVID-CT-MD dataset, a collection of lung Computed Tomography (CT) scan slices. Using Simulated Annealing as a stand-in for actual QA, we compare our method to classical transfer learning, using a neural network of the same order of magnitude, to display its improved classification performance. We find that our approach consistently outperforms its classical baseline in terms of test accuracy and AUC-ROC-Score and needs less training epochs to do this.

arXiv:2311.15966•IEEE International Conference on Quantum Computing and Engineering (QCE)•Sep 17, 2023•9 citations

Limitations of error corrected quantum annealing in improving the performance of Boltzmann machines

Richard Y. Li, Tameem Albash, Daniel A. Lidar

Abstract Boltzmann machines, a class of machine learning models, are the basis of several deep learning methods that have been successfully applied to both supervised and unsupervised machine learning tasks. These models assume that some given dataset is generated according to a Boltzmann distribution, and the goal of the training procedure is to learn the set of parameters that most closely match the input data distribution. Training such models is difficult due to the intractability of traditional sampling techniques, and proposals using quantum annealers for sampling hope to mitigate the cost associated with sampling. However, real physical devices will inevitably be coupled to the environment, and the strength of this coupling affects the effective temperature of the distributions from which a quantum annealer samples. To counteract this problem, error correction schemes that can effectively reduce the temperature are needed if there is to be some benefit in using quantum annealing for problems at a larger scale, where we might expect the effective temperature of the device to be too high. To this end, we have applied nested quantum annealing correction (NQAC) to do unsupervised learning with a small bars and stripes dataset, and to do supervised learning with a coarse-grained MNIST dataset, which consists of black-and-white images of hand-written integers. For both datasets we demonstrate improved training and a concomitant effective temperature reduction at higher noise levels relative to the unencoded case. We also find better performance overall with longer anneal times and offer an interpretation of the results based on a comparison to simulated quantum annealing and spin vector Monte Carlo. A counterintuitive aspect of our results is that the output distribution generally becomes less Gibbs-like with increasing nesting level and increasing anneal times, which shows that improved training performance can be achieved without equilibration to the target Gibbs distribution.

arXiv:1910.01283•Quantum Science and Technology•Jun 8, 2020•28 citations

Exploring Unsupervised Anomaly Detection with Quantum Boltzmann Machines in Fraud Detection

Jonas Stein, Daniëlle Schuman, Magdalena Benkard +7 more

Anomaly detection in Endpoint Detection and Response (EDR) is a critical task in cybersecurity programs of large companies. With rapidly growing amounts of data and the omnipresence of zero-day attacks, manual and rule-based detection techniques are no longer eligible in practice. While classical machine learning approaches to this problem exist, they frequently show unsatisfactory performance in differentiating malicious from benign anomalies. A promising approach to attain superior generalization than currently employed machine learning techniques are quantum generative models. Allowing for the largest representation of data on available quantum hardware, we investigate Quantum Annealing based Quantum Boltzmann Machines (QBMs) for the given problem. We contribute the first fully unsupervised approach for the problem of anomaly detection using QBMs and evaluate its performance on an EDR inspired synthetic dataset. Our results indicate that QBMs can outperform their classical analog (i.e., Restricted Boltzmann Machines) in terms of result quality and training steps in special cases. When employing Quantum Annealers from D-Wave Systems, we conclude that either more accurate classical simulators or substantially more QPU time is needed to conduct the necessary hyperparameter optimization allowing to replicate our simulation results on quantum hardware.

arXiv:2306.04998•International Conference on Agents and Artificial Intelligence (ICAART)•Jan 1, 2024•12 citations

Training Quantum Boltzmann Machines with Coresets

Joshua Viszlai, Teague Tomesh, Pranav Gokhale +2 more

Recent work has proposed and explored using coreset techniques for quantum algorithms that operate on classical data sets to accelerate the applicability of these algorithms on near-term quantum devices. We apply these ideas to Quantum Boltzmann Machines (QBM) where gradient-based steps which require Gibbs state sampling are the main computational bottle-neck during training. By using a coreset in place of the full data set, we try to minimize the number of steps needed and accelerate the overall training time. In a regime where computational time on quantum computers is a precious resource, we propose this might lead to substantial practical savings. We evaluate this approach on 6x6 binary images from an augmented bars and stripes data set using a QBM with 36 visible units and 8 hidden units. Using an Inception score inspired metric, we compare QBM training times with and without using coresets.

arXiv:2307.14459•IEEE International Conference on Quantum Computing and Engineering (QCE)•Sep 1, 2022•1 citation

A Novel Quantum Convolution Neural Network for Image Classification Applications

Venkatachalapathy Madhavanna Venkatappa, Venkateshappa

Image classification plays a vital role in large-scale data analysis, especially in object recognition tasks using advanced Deep Learning (DL) frameworks. However, the growing complexity and computational demands of modern DL models have introduced challenges related to scalability and efficiency. Quantum Computing (QC) has emerged as a promising alternative, capable of addressing these limitations by leveraging the principles of Quantum Machine Learning (QML). However, many existing QML models require a large number of qubits, which poses limitations within the current Noisy Intermediate-Scale Quantum (NISQ) era. This work introduces a novel Adaptive Quantum Convolutional Neural Network (AQCNN) designed for efficient and scalable image classification within the constraints of NISQ devices. Addressing the limitations of existing QML approaches, particularly the high qubit requirements, AQCNN incorporates a resource-efficient quantum convolutional layer that performs localized quantum filtering using parameterized quantum circuits. A classical preprocessing layer encodes input features to reduce qubit load, followed by quantum embedding and hybrid quantum-classical layers that optimize feature extraction and classification performance. The model leverages an adaptive quantum convolution strategy, minimizing quantum gate depth and circuit complexity while preserving critical spatial hierarchies in image data. Evaluated on benchmark datasets, AQCNN achieved 95.88% accuracy on MNIST and 95.68% on FMNIST, outperforming comparable QML architectures. Additionally, the model supports scalable execution through parallel quantum circuit arrays, enabling practical deployment on current quantum hardware. This architecture demonstrates a significant advance in quantum-assisted image classification, balancing performance with qubit and gate efficiency. The integration of adaptive quantum convolution and hybrid processing not only enhances classification accuracy but also provides a viable path forward for deploying QML solutions under realistic hardware constraints.

Engineering Technology & Applied Science Research•Oct 6, 2025•2 citations

A Quantum Convolutional Neural Network for Image Classification

Milind Upadhyay

From self-driving cars to medical diagnoses, machine learning (ML) has revolutionized our world in the last few decades. Additionally, Quantum Computing has considerable promise for the future, with superposition and entanglement making quantum algorithms much more efficient and effective than their classical counterparts. Quantum ML aims to apply these quantum principles to the groundbreaking field of ML, such as for image classification. Convolutional Neural Networks (CNNs) are very effective for classification, so we study a Quantum Convolutional Neural Network (QCNN) that is trained to distinguish between handwritten numbers in the MNIST dataset and compared to a similar-sized classical network. After tuning the QCNN and quantum encoding, the QCNN achieved comparable accuracy to the classical network.

•Dec 8, 2022•4 citations
Exploiting the fact that samples drawn from a quantum annealer inherently follow a boltzmann-like distribution, annealing-based Quantum Boltzmann Machines (QBMs) have gained increasing popularity in the quantum research community. While they harbor great promises for quantum speed-up, their usage currently stays a costly endeavor, as large amounts of QPU time are required to train them. This limits their applicability in the NISQ era. Following the idea of Noè et al. [1], who tried to alleviate this cost by incorporating parallel quantum annealing into their unsupervised training of QBMs, this paper presents an improved version of parallel quantum annealing that we employ to train QBMs in a supervised setting. Saving qubits to encode the inputs, the latter setting allows us to test our approach on medical images from the MedMNIST data set [2], thereby moving closer to real-world applicability of the technology. Our experiments show that QBMs using our approach already achieve reasonable results, comparable to those of similarly-sized Convolutional Neural Networks (CNNs), with a markedly smaller numbers of epochs than these classical models. Our using parallel annealing grants it a speed-up of almost 70% compared to regular annealing-based BM execution.
Quantum Transfer Learning (QTL) recently gained popularity as a hybrid quantum-classical approach for image classification tasks by efficiently combining the feature extraction capabilities of large Convolutional Neural Networks with the potential benefits of Quantum Machine Learning (QML). Existing approaches, however, only utilize gate-based Variational Quantum Circuits for the quantum part of these procedures. In this work we present an approach to employ Quantum Annealing (QA) in QTL-based image classification. Specifically, we propose using annealing-based Quantum Boltzmann Machines as part of a hybrid quantum-classical pipeline to learn the classification of real-world, large-scale data such as medical images through supervised training. We demonstrate our approach by applying it to the three-class COVID-CT-MD dataset, a collection of lung Computed Tomography (CT) scan slices. Using Simulated Annealing as a stand-in for actual QA, we compare our method to classical transfer learning, using a neural network of the same order of magnitude, to display its improved classification performance. We find that our approach consistently outperforms its classical baseline in terms of test accuracy and AUC-ROC-Score and needs less training epochs to do this.
Abstract Boltzmann machines, a class of machine learning models, are the basis of several deep learning methods that have been successfully applied to both supervised and unsupervised machine learning tasks. These models assume that some given dataset is generated according to a Boltzmann distribution, and the goal of the training procedure is to learn the set of parameters that most closely match the input data distribution. Training such models is difficult due to the intractability of traditional sampling techniques, and proposals using quantum annealers for sampling hope to mitigate the cost associated with sampling. However, real physical devices will inevitably be coupled to the environment, and the strength of this coupling affects the effective temperature of the distributions from which a quantum annealer samples. To counteract this problem, error correction schemes that can effectively reduce the temperature are needed if there is to be some benefit in using quantum annealing for problems at a larger scale, where we might expect the effective temperature of the device to be too high. To this end, we have applied nested quantum annealing correction (NQAC) to do unsupervised learning with a small bars and stripes dataset, and to do supervised learning with a coarse-grained MNIST dataset, which consists of black-and-white images of hand-written integers. For both datasets we demonstrate improved training and a concomitant effective temperature reduction at higher noise levels relative to the unencoded case. We also find better performance overall with longer anneal times and offer an interpretation of the results based on a comparison to simulated quantum annealing and spin vector Monte Carlo. A counterintuitive aspect of our results is that the output distribution generally becomes less Gibbs-like with increasing nesting level and increasing anneal times, which shows that improved training performance can be achieved without equilibration to the target Gibbs distribution.
Anomaly detection in Endpoint Detection and Response (EDR) is a critical task in cybersecurity programs of large companies. With rapidly growing amounts of data and the omnipresence of zero-day attacks, manual and rule-based detection techniques are no longer eligible in practice. While classical machine learning approaches to this problem exist, they frequently show unsatisfactory performance in differentiating malicious from benign anomalies. A promising approach to attain superior generalization than currently employed machine learning techniques are quantum generative models. Allowing for the largest representation of data on available quantum hardware, we investigate Quantum Annealing based Quantum Boltzmann Machines (QBMs) for the given problem. We contribute the first fully unsupervised approach for the problem of anomaly detection using QBMs and evaluate its performance on an EDR inspired synthetic dataset. Our results indicate that QBMs can outperform their classical analog (i.e., Restricted Boltzmann Machines) in terms of result quality and training steps in special cases. When employing Quantum Annealers from D-Wave Systems, we conclude that either more accurate classical simulators or substantially more QPU time is needed to conduct the necessary hyperparameter optimization allowing to replicate our simulation results on quantum hardware.
Recent work has proposed and explored using coreset techniques for quantum algorithms that operate on classical data sets to accelerate the applicability of these algorithms on near-term quantum devices. We apply these ideas to Quantum Boltzmann Machines (QBM) where gradient-based steps which require Gibbs state sampling are the main computational bottle-neck during training. By using a coreset in place of the full data set, we try to minimize the number of steps needed and accelerate the overall training time. In a regime where computational time on quantum computers is a precious resource, we propose this might lead to substantial practical savings. We evaluate this approach on 6x6 binary images from an augmented bars and stripes data set using a QBM with 36 visible units and 8 hidden units. Using an Inception score inspired metric, we compare QBM training times with and without using coresets.
Image classification plays a vital role in large-scale data analysis, especially in object recognition tasks using advanced Deep Learning (DL) frameworks. However, the growing complexity and computational demands of modern DL models have introduced challenges related to scalability and efficiency. Quantum Computing (QC) has emerged as a promising alternative, capable of addressing these limitations by leveraging the principles of Quantum Machine Learning (QML). However, many existing QML models require a large number of qubits, which poses limitations within the current Noisy Intermediate-Scale Quantum (NISQ) era. This work introduces a novel Adaptive Quantum Convolutional Neural Network (AQCNN) designed for efficient and scalable image classification within the constraints of NISQ devices. Addressing the limitations of existing QML approaches, particularly the high qubit requirements, AQCNN incorporates a resource-efficient quantum convolutional layer that performs localized quantum filtering using parameterized quantum circuits. A classical preprocessing layer encodes input features to reduce qubit load, followed by quantum embedding and hybrid quantum-classical layers that optimize feature extraction and classification performance. The model leverages an adaptive quantum convolution strategy, minimizing quantum gate depth and circuit complexity while preserving critical spatial hierarchies in image data. Evaluated on benchmark datasets, AQCNN achieved 95.88% accuracy on MNIST and 95.68% on FMNIST, outperforming comparable QML architectures. Additionally, the model supports scalable execution through parallel quantum circuit arrays, enabling practical deployment on current quantum hardware. This architecture demonstrates a significant advance in quantum-assisted image classification, balancing performance with qubit and gate efficiency. The integration of adaptive quantum convolution and hybrid processing not only enhances classification accuracy but also provides a viable path forward for deploying QML solutions under realistic hardware constraints.
From self-driving cars to medical diagnoses, machine learning (ML) has revolutionized our world in the last few decades. Additionally, Quantum Computing has considerable promise for the future, with superposition and entanglement making quantum algorithms much more efficient and effective than their classical counterparts. Quantum ML aims to apply these quantum principles to the groundbreaking field of ML, such as for image classification. Convolutional Neural Networks (CNNs) are very effective for classification, so we study a Quantum Convolutional Neural Network (QCNN) that is trained to distinguish between handwritten numbers in the MNIST dataset and compared to a similar-sized classical network. After tuning the QCNN and quantum encoding, the QCNN achieved comparable accuracy to the classical network.