Olivia Lanes, Mourad Beji, Antonio D. Corcoles, Constantin Dalyac, Jay Gambetta, Loïc Henriet, Ali Javadi-Abhari, Abhinav Kandala, Antonio Mezzacapo, Porter, Christopher, Sarah Sheldon, John Watrous, Christa Zoufal, Alexandre Dauphin, Borja Peropadre
As quantum computing approaches the threshold where certain tasks demonstrably outpace their classical machines, the need for a precise, clear, consensus-driven definition of quantum advantage becomes essential. Rapid progress in the field has blurred this term across companies, architectures, and application domains. Here, we aim to articulate an operational definition for quantum advantage that is both platform-agnostic and empirically verifiable. Building on this framework, we highlight the algorithmic families most likely to achieve early advantage. Finally, we outline our vision for the near future, in which quantum computers enhance existing high-performance computing platforms, enabling new frontiers in chemistry, materials discovery, optimization, and beyond.
As quantum computing approaches the threshold where certain tasks demonstrably outpace their classical machines, the need for a precise, clear, consensus-driven definition of quantum advantage becomes essential. Rapid progress in the field has blurred this term across companies, architectures, and application domains. Here, we aim to articulate an operational definition for quantum advantage that is both platform-agnostic and empirically verifiable. Building on this framework, we highlight the algorithmic families most likely to achieve early advantage. Finally, we outline our vision for the near future, in which quantum computers enhance existing high-performance computing platforms, enabling new frontiers in chemistry, materials discovery, optimization, and beyond.
Quantum computing has recently achieved experimental demonstrations of quantum advantage, marking a major milestone toward beyond-classical computation. However, translating these demonstrations into practical utility remains a central challenge. In this perspective, we argue that this transition is fundamentally limited by three interconnected gaps: the utility gap between benchmark tasks and real-world applications, the algorithmic gap between asymptotic quantum speedups and realistic performance, and the hardware gap imposed by noisy intermediate-scale devices. We further highlight that recent progress is beginning to narrow these gaps through the rapid maturation of quantum hardware, the emergence of resource-aware and practically grounded quantum algorithms, and the increasing integration of classical computation into the quantum workflow. Finally, we discuss potential early application domains for practical quantum advantage, while emphasizing that its ultimate realization will likely emerge from the co-evolution of hardware, algorithms, and application-driven discovery rather than any single breakthrough.
The integration of quantum computing and artificial intelligence (AI) constitutes a bidirectional synergy that is reshaping both disciplines. This review investigates the reciprocal relationship in which AI addresses foundational challenges in quantum computing, while quantum computing offers the potential to advance machine learning beyond classical constraints. Recent advancements exemplify this interaction: Google DeepMind’s AlphaQubit neural network decoder has achieved state-of-the-art quantum error correction, improving performance by 6% over tensor networks and 30% over correlated matching methods. Additionally, quantum neural networks have demonstrated exponential improvements in sample complexity for specific learning tasks. This review systematically examines the current landscape of quantum-AI integration across three primary dimensions. First, it addresses AI-enhanced quantum systems, such as transformer-based error correction, reinforcement learning for circuit optimization, and AI-driven hardware calibration. Second, it explores quantum-accelerated machine learning algorithms, including variational quantum neural networks, quantum generative adversarial networks, and quantum reinforcement learning. Third, it evaluates industry deployments in sectors such as life sciences, financial services, climate modeling, and pharmaceutical development. Notable examples include IonQ’s quantum chemistry simulations, which achieved 40% efficiency improvements in carbon capture material design; St. Jude’s identification of KRAS protein inhibitors using quantum machine learning with experimental validation; and JP Morgan Chase’s implementation of quantum portfolio optimization. The analysis indicates that the field has advanced from preliminary demonstrations to production-grade applications, especially in drug discovery and molecular simulation, where quantum computing offers measurable benefits. Nevertheless, several challenges remain, including barren plateaus in variational algorithms, scalability constraints in current noisy intermediate-scale quantum (NISQ) devices, requirements for real-time decoding speed, and the necessity for fault-tolerant quantum computing (FTQC) systems. IBM’s 2029 roadmap, which targets 200 logical qubits capable of executing 100 million gates, together with progress in high-rate quantum low-density parity-check codes, outlines a trajectory toward practical fault tolerance. This review makes two principal research contributions: Comprehensive Evaluation Framework for Quantum Advantage Assessment: We establish the first systematic, integrated methodology for determining quantum computing feasibility that combines problem characterization, resource estimation, quantum advantage assessment, and quantum algorithm paradigm selection. This framework consolidates criteria scattered across academic literature and industry practice into a unified decision-making tool applicable across chemistry, optimization, machine learning, and simulation domains. The framework addresses a critical industry need: enabling non-expert practitioners (chemists, financial analysts, materials scientists) to objectively assess quantum computing suitability without requiring deep quantum expertise. Novel Quantum Resource Optimization Algorithms: We present three concrete algorithmic contributions advancing quantum-AI integration: • Data Encoding Efficiency Algorithm that automatically selects optimal qubit encoding strategies (amplitude vs. angle encoding) minimizing total quantum resource consumption • Error Budget Optimization Algorithm that iteratively determines optimal quantum error correction code distance balancing logical error rate targets against physical qubit overhead • Real-time Hardware Specification Aggregation from multiple quantum cloud platforms (IBM Quantum, Amazon Braket, Google, IonQ) enabling dynamic feasibility assessment as hardware capabilities evolve Combined, these contributions establish quantum computing advantage assessment as a rigorous, data-driven discipline rather than ad-hoc expert judgment. The framework enables strategic quantum computing investment decisions, accelerates problem identification for early quantum utility, and provides a reference methodology for standardizing quantum advantage evaluation across academia and industry. This review synthesizes insights from recent academic literature, industry implementations, and expert perspectives to deliver a comprehensive assessment of quantum-AI synergies grounded in this evaluation framework. The mathematical foundations, ranging from quantum Fourier transforms to Gaussian processes, are examined. Best practices for researchers and practitioners are also outlined. The findings suggest that, although universal quantum advantage has not yet been realized, domain-specific quantum-AI applications in chemistry, optimization, and sensing are achieving practical utility in 2024-2025. This development marks a significant transition from theoretical potential to commercial realization, informed by rigorous evaluation methodologies.
Quantum computing holds the promise of revolutionizing various fields, including machine learning, by leveraging quantum phenomena to perform computations beyond the capabilities of classical computers. In this paper, we present a comparative study of quantum and classical algorithms in the context of machine learning tasks. We examine the advantages of quantum algorithms, such as quantum parallelism and entanglement, and their potential to outperform classical algorithms in tasks such as classification, clustering, and optimization. Through theoretical analysis and empirical experiments, we demonstrate the strengths and limitations of quantum machine learning algorithms, highlighting their potential for achieving quantum advantage in certain scenarios. Additionally, we discuss the challenges and opportunities for integrating quantum computing into machine learning pipelines and outline future research directions in this rapidly evolving field.
Integrating quantum mechanics into drug discovery marks a decisive shift from empirical trial-and-error toward quantitative precision. However, the prohibitive cost of ab initio molecular dynamics has historically forced a compromise between chemical accuracy and computational scalability. This paper identifies the convergence of High-Performance Computing (HPC), Machine Learning (ML), and Quantum Computing (QC) as the definitive solution to this bottleneck. While ML foundation models, such as FeNNix-Bio1, enable quantum-accurate simulations, they remain tethered to the inherent limits of classical data generation. We detail how High-Performance Quantum Computing (HPQC), utilizing hybrid QPU-GPU architectures, will serve as the ultimate accelerator for quantum chemistry data. By leveraging Hilbert space mapping, these systems can achieve true chemical accuracy while bypassing the heuristics of classical approximations. We show how this tripartite convergence optimizes the drug discovery pipeline, spanning from initial system preparation to ML-driven, high-fidelity simulations. Finally, we position quantum-enhanced sampling as the beyond GPU frontier for modeling reactive cellular systems and pioneering next-generation materials.
It is expected that quantum computers would enable solving various problems that are beyond the capabilities of the most powerful current supercomputers, which are based on classical technologies. In the last three decades, advances in quantum computing stimulated significant interest in this field from industry, investors, media, executives, and general public. However, the understanding of this technology, its current capabilities and its potential impact in these communities is still lacking. Closing this gap requires a complete picture of how to assess quantum computing devices' performance and estimate their potential, a task made harder by the variety of quantum computing models and physical platforms. Here we review the state of the art in quantum computing, promising computational models and the most developed physical platforms. We also discuss potential applications, the requirements posed by these applications and technological pathways towards addressing these requirements. Finally, we summarize and analyze the arguments for the quantum computing market's further exponential growth. The review is written in a simple language without equations, and should be accessible to readers with no advanced background in mathematics and physics.
In the realm of computational paradigms, quantum computing stands as the harbinger of an unprecedented era, promising to redefine the limits of problem-solving and data processing. Harnessing the principles of quantum mechanics, these machines leverage quantum bits (qubits) to perform calculations that defy the capabilities of classical computers. This review explores the transformative potential of quantum computers across various domains, from cryptography to material science, envisioning a future where complex simulations and optimizations once deemed impractical become routine. As quantum supremacy edges closer, this technology not only challenges the frontiers of computing but also beckons a new age of innovation and discovery