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arXiv:2502.08968 · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Quantum Approaches for Dysphonia Assessment in Small Speech Datasets

Ha Tran, Bipasha Kashyap, Pubudu Nishantha Pathirana

Published Jul 14, 2025• 4 citations
arXivHTMLPDF

Abstract

Dysphonia, a prevalent medical condition, leads to voice loss, hoarseness, or speech interruptions. To assess it, researchers have been investigating various machine learning techniques alongside traditional medical assessments. Convolutional Neural Networks (CNNs) have gained popularity for their success in audio classification and speech recognition. However, the limited availability of speech data, poses a challenge for CNNs. This study compares the performance of CNNs with standard convolutional layers, CNNs with random nonlinear convolutional layers (RANDOM models), and a novel hybrid quantum-classical architecture, Quanvolutional Neural Networks (QNNs), which are well-suited for small datasets. The audio data was preprocessed into Mel spectrograms, comprising 243 training samples and 61 testing samples in total, and used in four experiments. A total of six models were developed: two CNNs, two RANDOM models, and two QNNs, with the second models incorporating additional layers to boost performance. The angle encoding method was employed within the quanvolutional layer, which is the quantum transformation layer of the QNNs, to enable the representation of more complex features of Mel spectrogram. The experimental results demonstrated that QNN models consistently outperformed the CNN models in both classification accuracy (ranging from 82.22% ± 4% to 89.26% ± 2%) and convergence speed across all four experiments.Clinical relevance- This work investigates the potential of quantum-based approaches for medical data classification and their promising role in enhancing dysphonia assessment.

DOI
10.1109/embc58623.2025.11252849

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Dysphonia, a prevalent medical condition, leads to voice loss, hoarseness, or speech interruptions. To assess it, researchers have been investigating various machine learning techniques alongside traditional medical assessments. Convolutional Neural Networks (CNNs) have gained popularity for their success in audio classification and speech recognition. However, the limited availability of speech data, poses a challenge for CNNs. This study compares the performance of CNNs with standard convolutional layers, CNNs with random nonlinear convolutional layers (RANDOM models), and a novel hybrid quantum-classical architecture, Quanvolutional Neural Networks (QNNs), which are well-suited for small datasets. The audio data was preprocessed into Mel spectrograms, comprising 243 training samples and 61 testing samples in total, and used in four experiments. A total of six models were developed: two CNNs, two RANDOM models, and two QNNs, with the second models incorporating additional layers to boost performance. The angle encoding method was employed within the quanvolutional layer, which is the quantum transformation layer of the QNNs, to enable the representation of more complex features of Mel spectrogram. The experimental results demonstrated that QNN models consistently outperformed the CNN models in both classification accuracy (ranging from 82.22% ± 4% to 89.26% ± 2%) and convergence speed across all four experiments.Clinical relevance- This work investigates the potential of quantum-based approaches for medical data classification and their promising role in enhancing dysphonia assessment.
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Speech-based machine learning systems are sensitive to noise, complicating reliable deployment in emotion recognition and voice pathology detection. We evaluate the robustness of a hybrid quantum machine learning model, quanvolutional neural networks (QNNs) against classical convolutional neural networks (CNNs) under four acoustic corruptions (Gaussian noise, pitch shift, temporal shift, and speed variation) in a clean-train/corrupted-test regime. Using AVFAD (voice pathology) and TESS (speech emotion), we compare three QNN models (Random, Basic, Strongly) to a simple CNN baseline (CNN-Base), ResNet-18 and VGG-16 using accuracy and corruption metrics (CE, mCE, RCE, RmCE), and analyze architectural factors (circuit complexity or depth, convergence) alongside per-emotion robustness. QNNs generally outperform the CNN-Base under pitch shift, temporal shift, and speed variation (up to 22% lower CE/RCE at severe temporal shift), while the CNN-Base remains more resilient to Gaussian noise. Among quantum circuits, QNN-Basic achieves the best overall robustness on AVFAD, and QNN-Random performs strongest on TESS. Emotion-wise, fear is most robust (80-90% accuracy under severe corruptions), neutral can collapse under strong Gaussian noise (5.5% accuracy), and happy is most vulnerable to pitch, temporal, and speed distortions. QNNs also converge up to six times faster than the CNN-Base. To our knowledge, this is a systematic study of QNN robustness for speech under common non-adversarial acoustic corruptions, indicating that shallow entangling quantum front-ends can improve noise resilience while sensitivity to additive noise remains a challenge.
Introduction: Medical image classification is a crucial task in cancer diagnosis, relying on the accurate analysis of high-dimensional imaging data. While Convolutional Neural Networks (CNNs) have shown great success in this domain, their performance is often limited by the shallow feature expressiveness and overfitting, particularly in small or heterogeneous datasets. Methods: Quantum machine learning offers new opportunities through high-dimensional representations and nonlinear transformations. In this work, we propose a Quantum-Enhanced Sandwich Convolutional Neural Network (QSCNN), a layered hybrid architecture that integrates quantum and classical modules. The model employs a quanvolutional layer for localized quantum feature extraction, followed by conventional convolution and pooling for hierarchical representation learning, and a variational quantum classifier for nonlinear decision-making. Results: QSCNN achieved higher accuracy and training stability than classical CNNs and QCCNN baselines across three medical imaging tasks.: brain tumor MRI, skin cancer dermoscopy, and lung cancer CT. Circuit depth analysis revealed a trade-off between expressiveness and robustness, and additional experiments with depolarizing noise confirmed the model’s resilience under realistic quantum error conditions. Discussion: This suggests that circuit design choices influence hybrid model behavior and generalization, supporting the feasibility of quantum-enhanced methods for small-sample medical imaging. However, the current evaluation is limited to relatively small benchmark datasets, and broader validation on large-scale data will be essential to confirm clinical applicability. Conclusion: In summary, QSCNN presents a feasible hybrid framework for enhancing medical image classification with quantum features. While preliminary, our results suggest potential advantages in accuracy and stability under NISQ conditions.
Convolutional Neural Networks (CNNs) have shown promising results in efficiency and accuracy in image classification. However, their efficacy often relies on large, labeled datasets, posing challenges for applications with limited data availability. Our research addresses these challenges by introducing an innovative approach that leverages projected quantum kernels (PQK) to enhance feature extraction for CNNs, specifically tailored for small datasets. Projected quantum kernels, derived from quantum computing principles, offer a promising avenue for capturing complex patterns and intricate data structures that traditional CNNs might miss. By incorporating these kernels into the feature extraction process, we improved the representational ability of CNNs. Our experiments demonstrated that, with 1000 training samples, the PQK-enhanced CNN achieved 95% accuracy on the MNIST dataset and 90% on the CIFAR-10 dataset, significantly outperforming the classical CNN, which achieved only 60% and 12% accuracy on the respective datasets. This research reveals the potential of quantum computing in overcoming data scarcity issues in machine learning and paves the way for future exploration of quantum-assisted neural networks, suggesting that projected quantum kernels can serve as a powerful approach for enhancing CNN-based classification in data-constrained environments.
Abstract This study explores Quantum AI’s potential in enhancing Speech Emotion Recognition (SER) systems. Our primary objective is to evaluate the performance of quantum-inspired algorithms compared to classical machine-learning approaches in accurately identifying and classifying emotions from speech signals. We hypothesise that quantum computing techniques can improve the efficiency and accuracy of emotion recognition, particularly in handling complex, highdimensional acoustic data. We developed a hybrid quantum-classical model that combines quantum-inspired neural networks with traditional feature extraction techniques. Our approach utilises quantum circuits for data encoding and quantum variational algorithms for classification. We implemented quantum versions of support vector machines (QSVM) and quantum approximate optimisation algorithms (QAOA) for emotion classification tasks. These quantum methods were compared against a hybrid Convolutional Neural Network and Long Short Term (LSTM). The hybrid network is called a Convolutional Long Short Term network(CLSTM). The study employed a custom dataset for speech emotion recognition. We prepossessed the audio data to extract relevant acoustic features, including mel-frequency cepstral coefficients (MFCCs), pitch, and energy. In contrast, our implemented quantum-inspired model for this corpus showed lower performance, with the highest training accuracy of 30%, struggling with most emotions but performing best with ’Trust’. These varied results across different implementations suggest that while Quantum AI techniques show promise in advancing speech emotion recognition, their effectiveness may depend on the specific dataset, language, and model architecture used. Finally, the speed of a simulated quantum network is shown to outperform current methods in terms of matrix multiplication by leaps and bounds.
Pneumonia poses a significant global health challenge, demanding accurate and timely diagnosis. While deep learning, particularly Convolutional Neural Networks (CNNs), has shown promise in medical image analysis for pneumonia detection, CNNs often suffer from high computational costs, limitations in feature representation, and challenges in generalizing from smaller datasets. To address these limitations, we explore the application of Quanvolutional Neural Networks (QNNs), leveraging quantum computing for enhanced feature extraction. This paper introduces a novel hybrid quantum-classical model for pneumonia detection using the PneumoniaMNIST dataset. Our approach utilizes a quanvolutional layer with a parameterized quantum circuit (PQC) to process 2×2 image patches, employing rotational Y-gates for data encoding and entangling layers to generate non-classical feature representations. These quantum-extracted features are then fed into a classical neural network for classification. Experimental results demonstrate that the proposed QNN achieves a higher validation accuracy of 83.33% compared to a comparable classical CNN which achieves 73.33%. This enhanced convergence and sample efficiency highlight the potential of QNNs for medical image analysis, particularly in scenarios with limited labeled data. This research lays the foundation for integrating quantum computing into deep learning-driven medical diagnostic systems, offering a computationally efficient alternative to traditional approaches.