The rapid advancement in Quantum Computing, particularly through Noisy-Intermediate Scale Quantum (NISQ) devices, has spurred significant interest in Quantum Machine Learning (QML) applications. Despite their potential, fully-quantum algorithms remain impractical due to the limitations of current NISQ devices. Hybrid quantum-classical neural networks (HQNNs) have emerged as a viable alternative, leveraging both quantum and classical computations to enhance machine learning capabilities. However, the constrained resources of NISQ devices, particularly the limited number of qubits, pose significant challenges for executing large-scale quantum circuits. This work addresses these current challenges by proposing a novel and practical methodology for quantum circuit cutting of HQNNs, allowing large quantum circuits to be executed on limited-qubit NISQ devices. Our approach not only preserves the accuracy of the original circuits but also supports the training of quantum parameters across all subcircuits, which is crucial for the learning process in HQNNs. We propose a cutting methodology for HQNNs that employs a greedy algorithm for identifying efficient cutting points, and the implementation of trainable subcircuits, all designed to maximize the utility of NISQ devices in HQNNs. The findings suggest that quantum circuit cutting is a promising technique for advancing QML on current quantum hardware, since the cut circuit achieves comparable accuracy and much lower qubit requirements than the original circuit. The code is available at https://github.com/eBrain4Everyone/QNN-Cutting.
The rapid advancement in Quantum Computing, particularly through Noisy-Intermediate Scale Quantum (NISQ) devices, has spurred significant interest in Quantum Machine Learning (QML) applications. Despite their potential, fully-quantum algorithms remain impractical due to the limitations of current NISQ devices. Hybrid quantum-classical neural networks (HQNNs) have emerged as a viable alternative, leveraging both quantum and classical computations to enhance machine learning capabilities. However, the constrained resources of NISQ devices, particularly the limited number of qubits, pose significant challenges for executing large-scale quantum circuits. This work addresses these current challenges by proposing a novel and practical methodology for quantum circuit cutting of HQNNs, allowing large quantum circuits to be executed on limited-qubit NISQ devices. Our approach not only preserves the accuracy of the original circuits but also supports the training of quantum parameters across all subcircuits, which is crucial for the learning process in HQNNs. We propose a cutting methodology for HQNNs that employs a greedy algorithm for identifying efficient cutting points, and the implementation of trainable subcircuits, all designed to maximize the utility of NISQ devices in HQNNs. The findings suggest that quantum circuit cutting is a promising technique for advancing QML on current quantum hardware, since the cut circuit achieves comparable accuracy and much lower qubit requirements than the original circuit. The code is available at https://github.com/eBrain4Everyone/QNN-Cutting.
Quantum computing (QC) is a new paradigm offering the potential of exponential speedups over classical computing for certain computational problems. Each additional qubit doubles the size of the computational state space available to a QC algorithm. This exponential scaling underlies QC’s power, but today’s Noisy Intermediate-Scale Quantum (NISQ) devices face significant engineering challenges in scalability. The set of quantum circuits that can be reliably run on NISQ devices is limited by their noisy operations and low qubit counts. This paper introduces CutQC, a scalable hybrid computing approach that combines classical computers and quantum computers to enable evaluation of quantum circuits that cannot be run on classical or quantum computers alone. CutQC cuts large quantum circuits into smaller subcircuits, allowing them to be executed on smaller quantum devices. Classical postprocessing can then reconstruct the output of the original circuit. This approach offers significant runtime speedup compared with the only viable current alternative—purely classical simulations—and demonstrates evaluation of quantum circuits that are larger than the limit of QC or classical simulation. Furthermore, in real-system runs, CutQC achieves much higher quantum circuit evaluation fidelity using small prototype quantum computers than the state-of-the-art large NISQ devices achieve. Overall, this hybrid approach allows users to leverage classical and quantum computing resources to evaluate quantum programs far beyond the reach of either one alone.
Quantum machine learning has emerged as a promising approach to enhance computational efficiency by leveraging the principles of quantum computing. However, the limitations of current Noisy Intermediate-Scale Quantum (NISQ) devices, such as noise, limited qubit availability, and circuit depth constraints, restrict the implementation of fully quantum models. To address these challenges, this study focuses on the design, implementation, and performance evaluation of hybrid quantum-classical machine learning (HQML) models. The proposed approach integrates parameterized quantum circuits with classical optimization techniques to enable efficient learning within NISQ environments. The study employs standard benchmark datasets, including Iris, Breast Cancer, and MNIST, to evaluate the performance of the hybrid model. The results indicate that the HQML model achieves competitive accuracy on small and medium-sized datasets while maintaining balanced precision, recall, and F1-score. However, performance declines for complex datasets due to hardware limitations and noise effects. Additionally, the hybrid model demonstrates a lower number of parameters compared to classical deep learning models but requires higher training time due to iterative quantum-classical optimization. The findings highlight that hybrid quantum-classical models provide a practical and scalable approach for utilizing quantum computing in the current technological landscape. Although challenges related to noise, scalability, and computational overhead persist, advancements in quantum hardware and algorithm design are expected to improve performance. This study contributes to the growing field of quantum machine learning by providing a systematic framework for evaluating hybrid models on NISQ devices and identifying key areas for future research.
Noisy intermediate-scale quantum (NISQ) devices with limited qubit count and connectivity limit the scale of quantum circuits that can be executed. Circuit cutting methods simulate larger quantum computers by decomposing large circuits into small subcircuits that can be executed on NISQ hardware. Existing circuit cutting methods only consider the qubit count of the target hardware for finding the locations of cuts on the circuits. This can result in deeper subcircuits after mapping on the hardware. Fidelity decays exponentially with circuit depth and diminishes the quality of execution. We propose a circuit-cutting framework that reduces variance in the depth of subcircuits after mapping to the hardware. Our method formulates the initial circuit cutting as a multi-objective optimization problem based on an evolutionary search method with the number of cuts and the maximum depth of individual routed subcircuits as fitness objectives. This method is implemented as an extension to the existing Qiskit Circuit Cutting Addon, which allows for integration in existing flows. Our approach achieves reductions in routed subcircuit depth of up to 9.9% across benchmark circuits compared with baseline methods.
Machine Learning (ML) has been widely applied across numerous domains due to its ability to automatically identify informative patterns from data for various tasks. The availability of large-scale data and advanced computational power enables the development of sophisticated models and training strategies, leading to state-of-the-art performance, but it also introduces substantial challenges. Quantum Computing (QC), which exploits quantum mechanisms for computation, has attracted growing attention and significant global investment as it may address these challenges. Consequently, Quantum Machine Learning (QML), the integration of these two fields, has received increasing interest, with a notable rise in related studies in recent years. We are motivated to review these existing contributions regarding quantum circuit-based learning models for classical data analysis and highlight the identified potentials and challenges of this technique. Specifically, we focus not only on QML models, both kernel-based and neural network-based, but also on recent explorations of their integration with classical machine learning layers within hybrid frameworks. Moreover, we examine both theoretical analysis and empirical findings to better understand their capabilities, and we also discuss the efforts on noise-resilient and hardware-efficient QML that could enhance its practicality under current hardware limitations. In addition, we cover several emerging paradigms for advanced quantum circuit design and highlight the adaptability of QML across representative application domains. This study aims to provide an overview of the contributions made to bridge quantum computing and machine learning, offering insights and guidance to support its future development and pave the way for broader adoption in the coming years.
Protein-ligand binding affinity is critical in drug discovery, but experimentally determining it is time-consuming and expensive. Artificial intelligence (AI) has been used to predict binding affinity, significantly accelerating this process. However, the high-performance requirements and vast datasets involved in affinity prediction demand increasingly large AI models, requiring substantial computational resources and training time. Quantum machine learning has emerged as a promising solution to these challenges. In particular, hybrid quantum-classical models can reduce the number of parameters while maintaining or improving performance compared to classical counterparts. Despite these advantages, challenges persist: why hybrid quantum models achieve these benefits, whether quantum neural networks (QNNs) can replace classical neural networks, and whether such models are feasible on noisy intermediate-scale quantum (NISQ) devices. This study addresses these challenges by proposing a hybrid quantum neural network (HQNN) that empirically demonstrates the capability to approximate non-linear functions in the latent feature space derived from classical embedding. The primary goal of this study is to achieve a parameter-efficient model in binding affinity prediction while ensuring feasibility on NISQ devices. Numerical results indicate that HQNN achieves comparable or superior performance and parameter efficiency compared to classical neural networks, underscoring its potential as a viable replacement. This study highlights the potential of hybrid QML in computational drug discovery, offering insights into its applicability and advantages in addressing the computational challenges of protein-ligand binding affinity prediction.
Quantum computing has emerged as a transformative paradigm capable of addressing computational challenges beyond the reach of classical systems.In the current era of Noisy Intermediate-Scale Quantum (NISQ) devices, practical quantum hardware is characterized by limited qubit counts, short coherence times, gate errors, and the absence of full error correction.Despite these constraints, significant progress has been made in developing quantum machine learning (QML) techniques tailored to operate on near-term quantum processors.This paper presents a comprehensive review of Quantum Machine Learning in the context of NISQ computing.We first outline the fundamental principles of quantum computing, including qubits, superposition, entanglement, and quantum parallelism, followed by a detailed discussion of the NISQ computing model and its hardware limitations.The review then examines hybrid quantum-classical learning frameworks, variational quantum algorithms, quantum data encoding strategies, and noise mitigation techniques that enable practical implementation on existing platforms.Emerging applications across healthcare, finance, cybersecurity, climate modeling, and materials science are also surveyed to highlight the real-world potential of QML.Furthermore, key challenges such as scalability, trainability issues, and algorithmic robustness are analyzed, along with current research efforts aimed at overcoming these barriers.The paper concludes by identifying promising future directions for advancing QML toward quantum advantage.This review aims to provide researchers and practitioners with a structured understanding of the capabilities, limitations, and opportunities of quantum machine learning in the NISQ era .