There is much debate on whether quantum computing on current NISQ devices, consisting of noisy hundred qubits and requiring a non-negligible usage of classical computing as part of the algorithms, has utility and will ever offer advantages for scientific and industrial applications with respect to traditional computing. In this position paper, we argue that while real-world NISQ quantum applications have yet to surpass their classical counterparts, strategic approaches can be used to facilitate advancements in both industrial and scientific applications. We have identified three key strategies to guide NISQ computing towards practical and useful implementations. Firstly, prioritizing the identification of a "killer app" is a key point. An application demonstrating the distinctive capabilities of NISQ devices can catalyze broader development. We suggest focusing on applications that are inherently quantum, e.g., pointing towards quantum chemistry and material science as promising domains. These fields hold the potential to exhibit benefits, setting benchmarks for other applications to follow. Secondly, integrating AI and deep-learning methods into NISQ computing is a promising approach. Examples such as quantum Physics-Informed Neural Networks and Differentiable Quantum Circuits (DQC) demonstrate the synergy between quantum computing and AI. Lastly, recognizing the interdisciplinary nature of NISQ computing, we advocate for a co-design approach. Achieving synergy between classical and quantum computing necessitates an effort in co-designing quantum applications, algorithms, and programming environments, and the integration of HPC with quantum hardware. The interoperability of these components is crucial for enabling the full potential of NISQ computing. In conclusion, through the usage of these three approaches, we argue that NISQ computing can surpass current limitations and evolve into a valuable tool for scientific and industrial applications. This requires an approach that integrates domain-specific killer apps, harnesses the power of quantum-enhanced AI, and embraces a collaborative co-design methodology.
There is much debate on whether quantum computing on current NISQ devices, consisting of noisy hundred qubits and requiring a non-negligible usage of classical computing as part of the algorithms, has utility and will ever offer advantages for scientific and industrial applications with respect to traditional computing. In this position paper, we argue that while real-world NISQ quantum applications have yet to surpass their classical counterparts, strategic approaches can be used to facilitate advancements in both industrial and scientific applications. We have identified three key strategies to guide NISQ computing towards practical and useful implementations. Firstly, prioritizing the identification of a "killer app" is a key point. An application demonstrating the distinctive capabilities of NISQ devices can catalyze broader development. We suggest focusing on applications that are inherently quantum, e.g., pointing towards quantum chemistry and material science as promising domains. These fields hold the potential to exhibit benefits, setting benchmarks for other applications to follow. Secondly, integrating AI and deep-learning methods into NISQ computing is a promising approach. Examples such as quantum Physics-Informed Neural Networks and Differentiable Quantum Circuits (DQC) demonstrate the synergy between quantum computing and AI. Lastly, recognizing the interdisciplinary nature of NISQ computing, we advocate for a co-design approach. Achieving synergy between classical and quantum computing necessitates an effort in co-designing quantum applications, algorithms, and programming environments, and the integration of HPC with quantum hardware. The interoperability of these components is crucial for enabling the full potential of NISQ computing. In conclusion, through the usage of these three approaches, we argue that NISQ computing can surpass current limitations and evolve into a valuable tool for scientific and industrial applications. This requires an approach that integrates domain-specific killer apps, harnesses the power of quantum-enhanced AI, and embraces a collaborative co-design methodology.
Quantum computing has the potential to solve complex problems that are outside the scope of classical systems, making it a standard shifter. Current devices, which are considered as Noisy Intermediate-Scale Quantum (NISQ) systems, are insufficient in their practical utility due to hardware limitations, error rates, and qubit counts. The dynamic growths wanted to exceed the NISQ era and grow scalable quantum algorithms and architectures that can achieve useful quantum benefit in real-world applications are reviewed in this research. This research gives a comprehensive examination of the complications in scaling quantum systems, adjacent resource efficacy, qubit connectivity, and error correction. In addition to connecting architectural innovations like modular quantum computing, error-resilient circuit design, and distributed quantum systems, the paper provides new hybrid quantum-classical algorithms planned to exploit performance in noisy environments. Results from benchmarking in arenas like machine learning, optimization, and quantum chemistry show how these methods can provide short-term quantum benefit. Lastly, this paper proposes a research roadmap for quantum computing that highlights the requirement of co-designing algorithms, software, and hardware. The goal of this effort is to straighten the progress of quantum systems that can resolve problems in the real world at scale by addressing the inadequacies of NISQ devices and emphasizing scalable solutions.
The integration of quantum computing and artificial intelligence (AI) constitutes a bidirectional synergy that is reshaping both disciplines. This review investigates the reciprocal relationship in which AI addresses foundational challenges in quantum computing, while quantum computing offers the potential to advance machine learning beyond classical constraints. Recent advancements exemplify this interaction: Google DeepMind’s AlphaQubit neural network decoder has achieved state-of-the-art quantum error correction, improving performance by 6% over tensor networks and 30% over correlated matching methods. Additionally, quantum neural networks have demonstrated exponential improvements in sample complexity for specific learning tasks. This review systematically examines the current landscape of quantum-AI integration across three primary dimensions. First, it addresses AI-enhanced quantum systems, such as transformer-based error correction, reinforcement learning for circuit optimization, and AI-driven hardware calibration. Second, it explores quantum-accelerated machine learning algorithms, including variational quantum neural networks, quantum generative adversarial networks, and quantum reinforcement learning. Third, it evaluates industry deployments in sectors such as life sciences, financial services, climate modeling, and pharmaceutical development. Notable examples include IonQ’s quantum chemistry simulations, which achieved 40% efficiency improvements in carbon capture material design; St. Jude’s identification of KRAS protein inhibitors using quantum machine learning with experimental validation; and JP Morgan Chase’s implementation of quantum portfolio optimization. The analysis indicates that the field has advanced from preliminary demonstrations to production-grade applications, especially in drug discovery and molecular simulation, where quantum computing offers measurable benefits. Nevertheless, several challenges remain, including barren plateaus in variational algorithms, scalability constraints in current noisy intermediate-scale quantum (NISQ) devices, requirements for real-time decoding speed, and the necessity for fault-tolerant quantum computing (FTQC) systems. IBM’s 2029 roadmap, which targets 200 logical qubits capable of executing 100 million gates, together with progress in high-rate quantum low-density parity-check codes, outlines a trajectory toward practical fault tolerance. This review makes two principal research contributions: Comprehensive Evaluation Framework for Quantum Advantage Assessment: We establish the first systematic, integrated methodology for determining quantum computing feasibility that combines problem characterization, resource estimation, quantum advantage assessment, and quantum algorithm paradigm selection. This framework consolidates criteria scattered across academic literature and industry practice into a unified decision-making tool applicable across chemistry, optimization, machine learning, and simulation domains. The framework addresses a critical industry need: enabling non-expert practitioners (chemists, financial analysts, materials scientists) to objectively assess quantum computing suitability without requiring deep quantum expertise. Novel Quantum Resource Optimization Algorithms: We present three concrete algorithmic contributions advancing quantum-AI integration: • Data Encoding Efficiency Algorithm that automatically selects optimal qubit encoding strategies (amplitude vs. angle encoding) minimizing total quantum resource consumption • Error Budget Optimization Algorithm that iteratively determines optimal quantum error correction code distance balancing logical error rate targets against physical qubit overhead • Real-time Hardware Specification Aggregation from multiple quantum cloud platforms (IBM Quantum, Amazon Braket, Google, IonQ) enabling dynamic feasibility assessment as hardware capabilities evolve Combined, these contributions establish quantum computing advantage assessment as a rigorous, data-driven discipline rather than ad-hoc expert judgment. The framework enables strategic quantum computing investment decisions, accelerates problem identification for early quantum utility, and provides a reference methodology for standardizing quantum advantage evaluation across academia and industry. This review synthesizes insights from recent academic literature, industry implementations, and expert perspectives to deliver a comprehensive assessment of quantum-AI synergies grounded in this evaluation framework. The mathematical foundations, ranging from quantum Fourier transforms to Gaussian processes, are examined. Best practices for researchers and practitioners are also outlined. The findings suggest that, although universal quantum advantage has not yet been realized, domain-specific quantum-AI applications in chemistry, optimization, and sensing are achieving practical utility in 2024-2025. This development marks a significant transition from theoretical potential to commercial realization, informed by rigorous evaluation methodologies.
Quantum Artificial Intelligence (Quantum AI) embodies the integration of quantum computational paradigms with artificial intelligence frameworks to address the computational intractability and scalability constraints inherent in classical AI systems. By leveraging quantum mechanical properties such as superposition, entanglement, and quantum interference, Quantum AI enables enhanced representation learning, accelerated optimization, and improved probabilistic inference in high-dimensional problem spaces. In parallel, deep-tech innovations—including advanced deep learning architectures, neuromorphic computing, and edge-based intelligent processing—are redefining the architectural foundations of next- generation intelligent systems through energy-efficient, adaptive, and real-time computation. This paper presents a technically rigorous and comprehensive review of Quantum AI and deep-tech innovations, focusing on algorithmic formulations, architectural models, and system-level integration strategies. Core methodologies such as quantum machine learning algorithms, parameterized quantum circuits, variational quantum algorithms, and hybrid quantum–classical optimization frameworks are critically analysed with respect to computational complexity, repressibility, and feasibility on noisy intermediate-scale quantum (NISQ) hardware. Additionally, the role of neuromorphic computing in enabling spiking neural architectures and event-driven processing is examined as a complementary paradigm to quantum-enhanced learning models, particularly for low-power and latency-critical applications. The paper further investigates application- driven deployments of Quantum AI across domains including medical diagnostics, cryptographic security, autonomous decision-making, and smart cyber-physical systems, highlighting performance trade-offs and implementation constraints. Key challenges such as quantum noise, decoherence, data encoding bottlenecks, limited qubit connectivity, and ethical governance are systematically discussed. Finally, future research directions are identified, emphasizing fault-tolerant quantum learning architectures, scalable hybrid integration with deep-tech systems, and co-design methodologies for realizing practical next-generation intelligence platforms.
Artificial intelligence (AI) and quantum computing (QC) have emerged as two rapidly advancing computational paradigms, each facing distinct theoretical and practical challenges. In recent years, increasing attention has been directed toward their interaction, particularly in the context of hybrid quantum-classical systems suitable for noisy intermediate-scale quantum (NISQ) devices. This paper presents a structured analysis of the bidirectional relationship between AI and QC, examining how classical machine learning methods currently support quantum hardware operation, algorithm optimization, and error mitigation, while critically assessing the potential of quantum computing to enhance artificial intelligence in the longer term. Building on this analysis, we introduce a co-evolutionary co-design framework that characterizes feedback mechanisms across hardware, algorithmic, and application layers. The framework is intended as an analytical tool for understanding system-level dependencies rather than as a performance-optimizing prescription. To ground the discussion, we include a simulation-based case study in which a variational quantum circuit is optimized using a classical learning loop implemented with a hybrid quantum-classical workflow. The results demonstrate stable convergence behavior under idealized conditions, illustrating the feasibility of AI-assisted quantum optimization without claiming quantum advantage. By combining a critical literature review, a modest computational study, and a system-level design perspective, this work aims to provide a balanced reference for researchers investigating the near-term and long-term interactions between artificial intelligence and quantum computing.
The synergistic integration of quantum computational paradigms with artificial intelligence frameworks represents one of the most transformative technological frontiers of this decade. This comprehensive review provides a detailed technical examination of quantum artificial intelligence (QAI) from foundational principles to contemporary implementations. We systematically analyze the architectural frameworks of quantum machine learning systems, including quantum neural networks, variational quantum algorithms, and quantum-enhanced optimization methods. The paper presents a critical assessment of implementation challenges within the Noisy Intermediate-Scale Quantum (NISQ) computing paradigm, addressing decoherence effects, error mitigation methodologies, and the barren plateaus phenomenon. Through rigorous analysis of current literature and experimental implementations, we evaluate promising application domains including quantum chemistry, financial modeling, and materials science. The review concludes with a strategic roadmap for achieving practical quantum advantage in artificial intelligence applications, highlighting emerging research directions and hardware development trajectories.
The rapid development of deep learning and large language models (LMs) has led to a "computing inflation" phenomenon in the demand for computing power, energy consumption, and training time for artificial intelligence (AI). As classical computing gradually approaches its scalability bottleneck due to the slowing of Moore's Law and limitations imposed by memory walls and energy consumption, quantum computing (QC), with its properties such as superposition, entanglement, and quantum interference, is considered a candidate computing paradigm that may provide acceleration for specific sub-problems and bring new inductive biases to representation learning. This paper focuses on the application potential of quantum computing in artificial intelligence. It first establishes the theoretical foundation of quantum computing, then systematically outlines collaborative pathways that quantum computing can explore from three perspectives: AI training acceleration, data processing and representation learning, and neural networks and combinatorial optimization. Furthermore, this paper focuses on the most feasible quantum machine learning (QML) architectures for the Noisy Intermediate-Scale Quantum (NISQ) era, deeply comparing the design philosophy, data encoding strategies, parameter shift rule, shot complexity, and barren plateaus of Variational Quantum Circuits (VQC) and Quantum Neural Networks (QNN). Finally, this paper analyzes potential application areas in finance, pharmaceuticals/materials, natural language processing, and recommendation systems, and discusses key obstacles such as input/output bottlenecks, noise and error mitigation, benchmarking and verifiability, and governance and security. The paper concludes that in the short to medium term, quantum computing is more likely to serve as a "co-processor" for classical AI, providing gains in specific subtasks through a hybrid quantum-classical workflow. In the long term, however, the development of fault-tolerant quantum computing and scalable quantum error correction is necessary to achieve reproducible and cost-effective quantum advantages across a wider range of AI tasks.