Harnessing quantum correlations can enable sensing beyond classical precision limits, with the realization of such sensors poised for transformative impacts across science and engineering. Real devices, however, face the accumulated impacts of noise and architecture constraints, making the design and success of practical quantum sensors challenging. Numerical and theoretical frameworks to optimize and analyze sensing protocols in their entirety are thus crucial for translating quantum advantage into widespread practice. Here, we present an end-to-end variational framework for quantum sensing protocols, where parameterized quantum circuits and neural networks form trainable, adaptive models for quantum sensor dynamics and estimation, respectively. The framework is general and can be adapted towards arbitrary qubit architectures, as we demonstrate with experimentally-relevant ansätze for trapped-ion and photonic systems, and enables to directly quantify the impacts that noise and finite data sampling. End-to-end variational approaches can thus underpin powerful design and analysis tools for practical quantum sensing advantage.
Harnessing quantum correlations can enable sensing beyond classical precision limits, with the realization of such sensors poised for transformative impacts across science and engineering. Real devices, however, face the accumulated impacts of noise and architecture constraints, making the design and success of practical quantum sensors challenging. Numerical and theoretical frameworks to optimize and analyze sensing protocols in their entirety are thus crucial for translating quantum advantage into widespread practice. Here, we present an end-to-end variational framework for quantum sensing protocols, where parameterized quantum circuits and neural networks form trainable, adaptive models for quantum sensor dynamics and estimation, respectively. The framework is general and can be adapted towards arbitrary qubit architectures, as we demonstrate with experimentally-relevant ansätze for trapped-ion and photonic systems, and enables to directly quantify the impacts that noise and finite data sampling. End-to-end variational approaches can thus underpin powerful design and analysis tools for practical quantum sensing advantage.
Quantum sensing harnesses the unique properties of quantum systems to enable precision measurements of physical quantities such as time, magnetic and electric fields, acceleration, and gravitational gradients well beyond the limits of classical sensors. However, identifying suitable sensing probes and measurement schemes can be a classically intractable task, as it requires optimizing over Hilbert spaces of high dimension. In variational quantum sensing, a probe quantum system is generated via a parameterized quantum circuit (PQC), exposed to an unknown physical parameter through a quantum channel, and measured to collect classical data. PQCs and measurements are typically optimized using offline strategies based on frequentist learning criteria. This paper introduces an adaptive protocol that uses Bayesian inference to optimize the sensing policy via the maximization of the active information gain. The proposed variational methodology is tailored for non-asymptotic regimes where a single probe can be deployed in each time step, and is extended to support the fusion of estimates from multiple quantum sensing agents.
Quantum sensing technologies offer transformative potential for ultra-sensitive biomedical sensing, yet their clinical translation remains constrained by classical noise limits and a reliance on macroscopic ensembles. We propose a unifying generational framework to organize the evolving landscape of quantum biosensors based on their utilization of quantum resources. First-generation devices utilize discrete energy levels for signal transduction but follow classical scaling laws. Second-generation sensors exploit quantum coherence, extending precision with the coherence time up to the standard quantum limit, while third-generation architectures employ entanglement and spin squeezing to approach Heisenberg-limited precision. We define an emerging fourth generation characterized by the end-to-end integration of quantum sensing with quantum learning and variational circuits, enabling adaptive inference directly within the quantum domain. By introducing a bandwidth-matching analysis pairing the neural signal hierarchy with platform response bandwidths, classifying deployed clinical devices by precision-scaling class and sensor-tissue proximity, and outlining a staged physical-milestone roadmap toward learning-integrated sensor networks, we identify key technological bottlenecks and chart the transition from measuring physical observables to extracting structured biological information with quantum-enhanced intelligence.
Variational quantum sensing offers a promising route to high-precision parameter estimation, but its performance depends strongly on the circuit architectures used for probe preparation and measurement. Existing approaches typically optimize continuous parameters within predefined ansätze, restricting the accessible design space and limiting adaptation to sensing tasks and hardware constraints. Here, we introduce \textsc{AutoQSense}, a reinforcement-learning framework that searches circuit architectures using Fisher-information-based objectives. For few-qubit systems, a single agent sequentially constructs preparation and measurement circuits. For larger systems, a distributed formulation assigns local circuit design to subsystem agents and inter-block entanglement to a budgeted agent. Numerical results show that the learned architectures recover known benchmark strategies, adapt to dephasing noise, and outperform fixed hardware-efficient ansätze while using fewer entangling gates. These results establish \textsc{AutoQSense} as a resource-aware approach to adaptive and hardware-compatible quantum sensing.
Recent advances in Machine Learning have transformed numerous industrial sectors, yet classical paradigms face fundamental limitations: rapidly growing data volumes, rising computational costs, significant energy consumption, and the physical scaling limits of conventional hardware architectures. Quantum computing has emerged as a promising computational paradigm to address these challenges, giving rise to the field of Quantum Machine Learning (QML). In this thesis, the theoretical foundations of QML are investigated, with a focus on near-term and future practical applications. Three central challenges are addressed: the trainability of variational quantum circuits, their expressivity, and their resistance to efficient classical simulation. The trainability of Hamming-weight preserving variational quantum circuits is first studied, and theoretical guarantees are established that resolve an open conjecture on the absence of barren plateaus for this circuit family. Subspace-preserving QML algorithms are then introduced, including photonic circuits and quantum convolutional neural networks, and are designed to mimic classical ML subroutines while offering polynomial quantum advantage. Finally, variational quantum circuits are analyzed as quantum Fourier models, and a framework is derived to jointly characterize expressivity and trainability, from which conditions are obtained under which quantum models provably separate from their classical counterparts. These contributions are intended to advance the theoretical roadmap for harnessing near-term and future quantum technologies in real-world applications.
Variational Quantum Circuits (VQCs) have emerged as a cornerstone of hybrid quantum–classical algorithms designed to harness the computational potential of near-term quantum devices. By combining parameterized quantum gates with classical optimization, VQCs provide a flexible framework for tackling machine learning, chemistry, and optimization problems intractable for classical methods. This review comprehensively overviews VQC design principles, ansatz structures, optimization strategies, and real-world applications. Furthermore, we discuss fundamental challenges such as barren plateaus, the expressibility–trainability trade-off, and current noisy intermediate-scale quantum (NISQ) hardware limitations. Finally, we highlight emerging directions that could enable scalable, noise-resilient, and physically interpretable variational quantum models for future quantum computing applications
Variational quantum learning faces practical challenges in the noisy intermediate-scale quantum (NISQ) era. Parameterized quantum circuit (PQC) models suffer from statistical uncertainty due to finite-shot measurements and are highly sensitive to quantum noise, while purely classical approximations like neural quantum states (NQS) lack access to genuine quantum correlations and are limited in scalability. This work introduces Hybrid Parameterized Quantum States (HPQS), a general-purpose modeling framework that interpolates between quantum and classical parameterizations. HPQS combines PQC-based measurements with neural estimators via a blending mechanism and postprocessing functions, enabling enhanced, shot-efficient evaluation under hardware constraints. We demonstrate HPQS across three representative quantum learning tasks: (1) Expectation-based QML, where HPQS yields higher classification accuracy than PQC-only and NQS-only baselines under limited quantum measurements. (2) Quantum-Train, where HPQS generates the entire parameter set of classical networks using polylogarithmic trainable variables; and (3) Quantum Parameter Adaptation (QPA), where HPQS produces LoRA adapter parameters for fine-tuning large language models like GPT-2 and Gemma-2 with improved perplexity under low-shot conditions; Together, these results position HPQS as a scalable, noise-resilient approach for variational quantum learning, compatible with both current NISQ hardware and future fault-tolerant architectures.