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arXiv:2302.04633

Histopathological Cancer Detection Using Hybrid Quantum Computing

Reek Majumder, Biswaraj Baral, Bhavika Bhalgamiya, Taposh Dutta Roy

Published Feb 7, 2023• 9 citations
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Abstract

We present an effective application of quantum machine learning in the field of healthcare. The study here emphasizes on a classification problem of a histopathological cancer detection using quantum transfer learning. Rather than using single transfer learning model, the work model presented here consists of multiple transfer learning models especially ResNet18, VGG-16, Inception-v3, AlexNet and several variational quantum circuits (VQC) with high expressibility. As a result, we provide a comparative analysis of the models and the best performing transfer learning model with the prediction AUC of approximately 93 percent for histopathological cancer detection. We also observed that for 1000 images with Resnet18, Hybrid Quantum and Classical (HQC) provided a slightly better accuracy of 88.5 percent than classical of 88.0 percent.

DOI
10.48550/arxiv.2302.04633

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We present an effective application of quantum machine learning in the field of healthcare. The study here emphasizes on a classification problem of a histopathological cancer detection using quantum transfer learning. Rather than using single transfer learning model, the work model presented here consists of multiple transfer learning models especially ResNet18, VGG-16, Inception-v3, AlexNet and several variational quantum circuits (VQC) with high expressibility. As a result, we provide a comparative analysis of the models and the best performing transfer learning model with the prediction AUC of approximately 93 percent for histopathological cancer detection. We also observed that for 1000 images with Resnet18, Hybrid Quantum and Classical (HQC) provided a slightly better accuracy of 88.5 percent than classical of 88.0 percent.
This study presents an effective analysis of a hybrid transfer learning algorithm in medical image processing, specifically focusing on histopathological cancer detection. The research involves a two-part approach. First, a hybrid model was created, combining classical and quantum units for classifying images into cancerous and non-cancerous cells. Second, the performance of this hybrid model was compared with traditional models, quantum simulators like Pennylane, and IBM's real quantum computers (Lima, Quito, Belem, and Jakarta), considering factors such as the number of qubits, Variational Quantum Classifier (VQC), and number of images. The objective was to aid users in selecting the optimal combination of classical and quantum units for accurate classification. The study found that the hybrid transfer learning model, when used with the Pennylane quantum simulator, yielded slightly higher accuracy than hybrid models implemented with IBM's quantum computers.
With millions of medical data being produced daily, it is important to leverage current technology to improve the healthcare system. As traditional deep learning models are unable to effectively handle high-dimensional data, a hybrid classical-quantum approach is used to enhance traditional deep learning algorithms. The hybrid classical-quantum models are built upon the classical deep learning framework with quantum techniques. The classical layers are utilized for feature extraction while the quantum layer is used for computational tasks. This addresses computational limitations and data imbalance challenges in medical image analysis. Transfer learning models, such as ResNet18 and InceptionV3, are used in conjunction with a quantum variational circuit to perform the task. The model is trained on a chest X-ray dataset, which consists of two sets of data: binary and multiclass. The binary dataset consists of Normal and COVID-19 images, while the multiclass dataset has COVID-19, Normal, and Tuberculosis images for classification. PennyLane, as a simulator, has been used to perform quantum computing. The dataset has also been used to train the traditional transfer learning models, pre-trained ResNet18, and their results have been compared. Out of all the models tested, the hybrid classical-quantum model, namely Hybrid ResNet18, performed the best. It achieved an accuracy of 93.22% for the binary classification task and 93.91% for the multiclass classification. The results show that there is a statistically significant improvement in classification accuracy and F1-score of the hybrid approach over the classical transfer learning baselines under a simulation-based environment. This sets the stage for further research on real-world physical quantum hardware. Class imbalance and overlapping predictions have been addressed using methods such as data augmentation and confusion matrix analysis. Thus, quantum machine learning could be used as a vital tool to analyze medical data for better diagnostic results.
The need to have rapid technological solutions is becoming more evident as the information world digitizes and the amount of data around us grows.It is argued that the future of computational systems will be quantum computing, which will be faster and more capable of solving several issues that cannot be solved with current computers.The aim of the current research is to examine the contributions made by quantum transfer learning models in enhancing the detection of breast cancer.Although both classical and deep learning approaches have proved to be effective, they continue to face serious challenges in handling high-dimensional and complex medical data.Quantum computing can be a feasible solution to such complexity.This study presents a hybrid model, which combines a classical pre-trained deep learning model ( ResNet50) with a range of variational quantum circuits-simple, entangled, and more complex.The main goal is to find the best model set up with regard to predictive power and computation time.It has been found that a hybrid model with an entangled variational circuit has an accuracy of 98.46, a precision of 100, and an F1-score of 97.3, which means a better result compared to the standard transfer learning model, which had an accuracy of 94.6, a precision of 97, and an F1-score of 90.4.These results improve upon recent quantum transfer learning studies, such as Azevedo et al. (2022) with 84% accuracy, and align closely with state-of-the-art quantumoptimized models reporting up to 99.3% accuracy, highlighting the effectiveness of our entangled variational approach on ultrasound images.Meanwhile, the traditional transfer learning model was the best in computational resource utilization.
This paper investigates quantum image processing for histopathological cancer detection, focusing on enhanced feature extraction and improved classification. We propose a hybrid quantum-classical framework in which quantum preprocessing circuits, specifically, Quantum Hadamard Edge Detection (QHED) and the Quantum Fourier Transform (QFT), extract subtle spatial and spectral features from hematoxylin and eosin-stained whole-slide images. These quantum-enhanced features are then classified using deep neural networks such as ResNet-50, VGG-16, and UNet. Experiments on the PatchCamelyon dataset demonstrate that quantum-enhanced preprocessing increases sensitivity in detecting cancerous regions, while integrating hybrid preprocessing with an SVM classifier further improves classification accuracy. Although quantum noise remains a challenge, our results highlight the promise of quantum image pre-processing and feature extraction for advancing histopathological image classification.
The integration of quantum computing with classical machine learning presents novel approaches to solving complex problems. This research focuses on developing a Quantum-Classical Hybrid Cancer Classification System using a quantum variational circuit for feature extraction and a classical SVM model for comparison. Breast cancer datasets were analyzed to demonstrate the potential of hybrid quantum-classical models in medical diagnostics. The results show that the quantum model achieves comparable performance to classical models with distinctive computational efficiency, offering a promising pathway for the future of quantum machine learning in healthcare.
Breast cancer is one of the most prevalent and life-threatening diseases affecting women worldwide, and early detection plays a crucial role in improving survival rates and treatment outcomes.Conventional diagnostic methods such as mammography, ultrasound imaging, and histopathological analysis rely heavily on expert interpretation and classical machine learning techniques.Although classical deep learning models, especially Convolutional Neural Networks (CNNs), have demonstrated impressive performance in medical image analysis, they face inherent limitations related to computational complexity, scalability, and the curse of dimensionality when handling large, high-resolution datasets.With the rapid advancement of quantum computing, Quantum Machine Learning (QML) has emerged as a promising paradigm capable of addressing these challenges by leveraging quantum phenomena such as superposition and entanglement.This research explores the application of Quantum Convolutional Neural Networks (Quantum CNNs or QCNNs) for breast cancer detection, aiming to enhance classification accuracy while reducing computational overhead.The proposed approach integrates quantum circuits with classical preprocessing techniques to extract discriminative features from breast cancer datasets, such as mammographic or histopathological images.By encoding image features into quantum states and performing convolution operations through parameterized quantum circuits, the Quantum CNN model is designed to learn complex patterns more efficiently than classical counterparts.The study evaluates the effectiveness of Quantum CNNs in distinguishing between benign and malignant breast tumors and compares its performance with traditional CNN models.The findings highlight the potential of Quantum CNNs to revolutionize medical image analysis by offering faster convergence, improved generalization, and robustness against noise.This research contributes to the growing field of quantumassisted healthcare systems and demonstrates how quantum computing can be harnessed to address critical challenges in breast cancer diagnosis.