© 2026 Aqora Quantum S.A.S.

Terms Privacy Legal Notice

arXiv:2205.01292 · Physical Review Applied

Quantum Optical Coherence Microscopy for Bioimaging Applications

Pablo Yepiz-Graciano, Zeferino Ibarra-Borja, Roberto Ramírez-Alarcón, Gerardo Gutierrez-Torres, Héctor Cruz-Ramírez, Dorilian Lopez-Mago, Alfred B. U’Ren

Published Sep 22, 2022• 20 citations

Abstract

Quantum-optical coherence tomography (QOCT) is an optical sectioning modality based on the quantum interference of entangled photon pairs in the well-known Hong-Ou-Mandel interferometer. Despite its promise, the technique is far from being competitive with current classical OCT devices due to the long required acquisition times, derived from the low photon-pair emission rates. In this work, we, on the one hand, demonstrate a quantum optical coherence microscopy technique, based on full-field QOCT, which employs entangled collinear photon pairs in a Linnik interferometer designed to overcome some of the limitations of previous QOCT implementations, and, on the other hand, test it on representative samples, including glass layers with manufactured transverse patterns and metal-coated biological specimens. In our setup, while the idler photon is collected with a multimode fiber, the signal photon is detected by an intensified charge-coupled device camera, leading to full-field transverse reconstruction through a single-axial acquisition sequence. Interestingly, our setup permits concurrent OCT and QOCT trace acquisition, the former with greater counts and the latter with the benefit of quantum-conferred advantages. We hope that our current results will represent a significant step forward towards the actual applicability of QOCT, e.g., in clinical settings.

DOI: 10.1103/physrevapplied.18.034060

Related papers

Experimental demonstration of full-field quantum optical coherence tomography

Zeferino Ibarra-Borja, Carlos Sevilla-Gutiérrez, Roberto Ramírez-Alarcón +2 more

We present, to the best of our knowledge, the first implementation of full-field quantum optical coherence tomography (FF-QOCT). In our system, we are able to obtain full three-dimensional (3D) information about the internal structure of a sample under study by relying on transversely resolved Hong–Ou–Mandel (HOM) interferometry with the help of an intensified CCD (ICCD) camera. Our system requires a single axial scan, obtaining full-field transverse single-photon intensity in coincidence with the detection of the sibling photon for each value of the signal-idler temporal delay. We believe that this capability constitutes a significant step forward toward the implementation of QOCT as a practical biomedical imaging technique.

Photonics Research•Dec 19, 2019•36 citations

Phase-dependent quantum optical coherence tomography

Mayte Y. Li-Gómez, Taras Hrushevskyi, Kayla McArthur +3 more

Two-photon interference is a cornerstone of quantum optics, enabling imaging, sensing, and precision measurements that surpass classical limits. By harnessing the quantum interference of photon pairs, as demonstrated by the Hong-Ou-Mandel effect, this approach offers superior axial resolution and intrinsic dispersion cancellation, along with strong noise suppression arising from the precise temporal correlations between photons. Building on these principles, we present the theoretical framework and experimental realization of phase-dependent quantum optical coherence tomography (QOCT), a technique that employs phase-modulated two-photon interference for noninvasive morphological analysis of multilayered samples. We demonstrate that introducing controlled phase shifts to photon pairs in a Hong-Ou-Mandel interferometer effectively eliminates artifacts caused by reflections at different sample layers, thereby greatly improving the accuracy and reliability of QOCT measurements. This work advances the fundamental understanding and practical deployment of two-photon interference, overcoming a key limitation in applying QOCT to real-world applications such as biomedical imaging and materials characterization.

arXiv:2503.06772•Physical Review Research•Sep 19, 2025•0 citations

Cross-correlation scheme for quantum optical coherence tomography based on Michelson interferometer

Anna Romanova, Vadim Rodimin, Konstantin Katamadze

Quantum optical coherence tomography (QOCT) offers a simple way to cancel dispersion broadening in a sample while also providing twice the resolution compared to classical OCT. However, to achieve these advantages, a bright and broadband source of entangled photon pairs is required. A simple implementation uses collinear spontaneous parametric down-conversion in a Michelson interferometer (MI), yet this autocorrelation scheme suffers from parasitic terms and sensitivity to phase noise. Here, we introduce a cross-correlation MI-based QOCT that overcomes these drawbacks, significantly advancing QOCT toward practical applications.

arXiv:2505.08095•Physical Review Applied•Nov 24, 2025•1 citation

On using classical light in Quantum Optical Coherence Tomography

Jakub Szlachetka, Sylwia M. Kolenderska, Piotr Leszek Kolenderski

Quantum Optical Coherence Tomography (Q-OCT) presents many advantages over its classical counterpart, Optical Coherence Tomography (OCT): it provides an increased axial resolution and is immune to even orders of dispersion. The core of Q-OCT is quantum interference of negatively correlated entangled photon pairs obtained in a Hong-Ou-Mandel configuration. This two-photon interference can be observed in the time domain in the form of dips or in the Fourier domain by means of a joint spectrum. The latter approach proved to be practical in the sense that it alleviated the requirement posed on light in Q-OCT to exhibit strict negative correlations, since the negative correlations can be easily extracted in the Fourier domain as the main diagonal of the joint spectrum. In this work, we investigate the use of this spectral approach in which quantum interference is obtained with classical low-intensity light pulses. We report theoretical calculations and their experimental validation and show that although such classical light is much easier to launch into an experimental system, it offers limited benefits as compared to Q-OCT based on entangled light. We analyse the differences in the characteristics of the joint spectrum obtained with entangled photons and with classical light and explain the origins of these differences.

arXiv:2103.14967•Mar 27, 2021•0 citations

Interference effects in quantum-optical coherence tomography using spectrally engineered photon pairs

Pablo Yepiz-Graciano, Alí Michel Angulo Martínez, Dorilian Lopez-Mago +6 more

Optical-coherence tomography (OCT) is a technique that employs light in order to measure the internal structure of semitransparent, e.g. biological, samples. It is based on the interference pattern of low-coherence light. Quantum-OCT (QOCT), instead, employs the correlation properties of entangled photon pairs, for example, generated by the process of spontaneous parametric downconversion (SPDC). The usual QOCT scheme uses photon pairs characterised by a joint-spectral amplitude with strict spectral anti-correlations. It has been shown that, in contrast with its classical counterpart, QOCT provides resolution enhancement and dispersion cancellation. In this paper, we revisit the theory of QOCT and extend the theoretical model so as to include photon pairs with arbitrary spectral correlations. We present experimental results that complement the theory and explain the physical underpinnings appearing in the interference pattern. In our experiment, we utilize a pump for the SPDC process ranging from continuous wave to pulsed in the femtosecond regime, and show that cross-correlation interference effects appearing for each pair of layers may be directly suppressed for a sufficiently large pump bandwidth. Our results provide insights and strategies that could guide practical implementations of QOCT.

arXiv:2005.09842•Scientific Reports•Jun 20, 2019•41 citations

Quantum optical coherence tomography using three time-energy entangled photons

Dorilian Lopez-Mago, Arturo Burguete Lopez, Eernesto Campos

Quantum Optical Coherence Tomography can achieve a greater image resolution compared to its classical counterpart, due to the entanglement of the photon pairs. Following the idea that higher the number of entangled photons, higher the resolution, we study the physical underpinnings that appear when using photon triplets. Unlike the usual Hong-Ou-Mandel interferometer used for QOCT, a much simpler implementation in the form of a Michelson interferometer is used in this work. We find that axial resolution can be improved by a factor of four. Additionally, we provide the numerical method to reconstruct the image given the triple coincidence rate.

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE•Sep 13, 2016•0 citations

Quantum-optical coherence tomography (QOCT) is an optical sectioning modality based on the quantum interference of entangled photon pairs in the well-known Hong-Ou-Mandel interferometer. Despite its promise, the technique is far from being competitive with current classical OCT devices due to the long required acquisition times, derived from the low photon-pair emission rates. In this work, we, on the one hand, demonstrate a quantum optical coherence microscopy technique, based on full-field QOCT, which employs entangled collinear photon pairs in a Linnik interferometer designed to overcome some of the limitations of previous QOCT implementations, and, on the other hand, test it on representative samples, including glass layers with manufactured transverse patterns and metal-coated biological specimens. In our setup, while the idler photon is collected with a multimode fiber, the signal photon is detected by an intensified charge-coupled device camera, leading to full-field transverse reconstruction through a single-axial acquisition sequence. Interestingly, our setup permits concurrent OCT and QOCT trace acquisition, the former with greater counts and the latter with the benefit of quantum-conferred advantages. We hope that our current results will represent a significant step forward towards the actual applicability of QOCT, e.g., in clinical settings.

We present, to the best of our knowledge, the first implementation of full-field quantum optical coherence tomography (FF-QOCT). In our system, we are able to obtain full three-dimensional (3D) information about the internal structure of a sample under study by relying on transversely resolved Hong–Ou–Mandel (HOM) interferometry with the help of an intensified CCD (ICCD) camera. Our system requires a single axial scan, obtaining full-field transverse single-photon intensity in coincidence with the detection of the sibling photon for each value of the signal-idler temporal delay. We believe that this capability constitutes a significant step forward toward the implementation of QOCT as a practical biomedical imaging technique.

Two-photon interference is a cornerstone of quantum optics, enabling imaging, sensing, and precision measurements that surpass classical limits. By harnessing the quantum interference of photon pairs, as demonstrated by the Hong-Ou-Mandel effect, this approach offers superior axial resolution and intrinsic dispersion cancellation, along with strong noise suppression arising from the precise temporal correlations between photons. Building on these principles, we present the theoretical framework and experimental realization of phase-dependent quantum optical coherence tomography (QOCT), a technique that employs phase-modulated two-photon interference for noninvasive morphological analysis of multilayered samples. We demonstrate that introducing controlled phase shifts to photon pairs in a Hong-Ou-Mandel interferometer effectively eliminates artifacts caused by reflections at different sample layers, thereby greatly improving the accuracy and reliability of QOCT measurements. This work advances the fundamental understanding and practical deployment of two-photon interference, overcoming a key limitation in applying QOCT to real-world applications such as biomedical imaging and materials characterization.

Quantum optical coherence tomography (QOCT) offers a simple way to cancel dispersion broadening in a sample while also providing twice the resolution compared to classical OCT. However, to achieve these advantages, a bright and broadband source of entangled photon pairs is required. A simple implementation uses collinear spontaneous parametric down-conversion in a Michelson interferometer (MI), yet this autocorrelation scheme suffers from parasitic terms and sensitivity to phase noise. Here, we introduce a cross-correlation MI-based QOCT that overcomes these drawbacks, significantly advancing QOCT toward practical applications.

Quantum Optical Coherence Tomography (Q-OCT) presents many advantages over its classical counterpart, Optical Coherence Tomography (OCT): it provides an increased axial resolution and is immune to even orders of dispersion. The core of Q-OCT is quantum interference of negatively correlated entangled photon pairs obtained in a Hong-Ou-Mandel configuration. This two-photon interference can be observed in the time domain in the form of dips or in the Fourier domain by means of a joint spectrum. The latter approach proved to be practical in the sense that it alleviated the requirement posed on light in Q-OCT to exhibit strict negative correlations, since the negative correlations can be easily extracted in the Fourier domain as the main diagonal of the joint spectrum. In this work, we investigate the use of this spectral approach in which quantum interference is obtained with classical low-intensity light pulses. We report theoretical calculations and their experimental validation and show that although such classical light is much easier to launch into an experimental system, it offers limited benefits as compared to Q-OCT based on entangled light. We analyse the differences in the characteristics of the joint spectrum obtained with entangled photons and with classical light and explain the origins of these differences.

Optical-coherence tomography (OCT) is a technique that employs light in order to measure the internal structure of semitransparent, e.g. biological, samples. It is based on the interference pattern of low-coherence light. Quantum-OCT (QOCT), instead, employs the correlation properties of entangled photon pairs, for example, generated by the process of spontaneous parametric downconversion (SPDC). The usual QOCT scheme uses photon pairs characterised by a joint-spectral amplitude with strict spectral anti-correlations. It has been shown that, in contrast with its classical counterpart, QOCT provides resolution enhancement and dispersion cancellation. In this paper, we revisit the theory of QOCT and extend the theoretical model so as to include photon pairs with arbitrary spectral correlations. We present experimental results that complement the theory and explain the physical underpinnings appearing in the interference pattern. In our experiment, we utilize a pump for the SPDC process ranging from continuous wave to pulsed in the femtosecond regime, and show that cross-correlation interference effects appearing for each pair of layers may be directly suppressed for a sufficiently large pump bandwidth. Our results provide insights and strategies that could guide practical implementations of QOCT.

Quantum Optical Coherence Tomography can achieve a greater image resolution compared to its classical counterpart, due to the entanglement of the photon pairs. Following the idea that higher the number of entangled photons, higher the resolution, we study the physical underpinnings that appear when using photon triplets. Unlike the usual Hong-Ou-Mandel interferometer used for QOCT, a much simpler implementation in the form of a Michelson interferometer is used in this work. We find that axial resolution can be improved by a factor of four. Additionally, we provide the numerical method to reconstruct the image given the triple coincidence rate.